Identification and validation of shared key genes between Parkinson's disease and erectile dysfunction: a bioinformatics approach [0.03%]
帕金森病与勃起功能障碍共通的关键基因的鉴定及验证：生物信息学方法
Yincheng Fan,Guangqian Gao,Yurong Xiang et al.
Yincheng Fan et al.
Background: Erectile dysfunction (ED) and Parkinson's disease (PD) are prevalent conditions that considerably impair patients' quality of life. Emerging evidence suggests a potential relationship between ED and PD, possib...
Single-cell transcriptomic analysis of peripheral blood mononuclear cells reveals key immune responses in ST-segment elevation myocardial infarction [0.03%]
单细胞转录组分析揭示了ST段抬高型心肌梗死外周血单个核细胞中的关键免疫反应
Zheng Zhang,Shengfang Wang,Yahui Liu et al.
Zheng Zhang et al.
Integrative analysis of Helicobacter pylori-driven stomach adenocarcinoma reveals epigenetic deregulation, immune evasion, and therapeutic resistance [0.03%]
整合分析揭示幽门螺旋杆菌驱动的胃腺癌出现表观遗传失调、免疫逃逸和治疗抵抗
Mohammed Alissa
Mohammed Alissa
Background: Helicobacter pylori (H. pylori) infection is a major etiological factor for stomach adenocarcinoma (STAD), yet the key molecular drivers linking infection to tumor progression remain insufficiently defined. Th...
Coptisine regulates PI3K/AKT pathway to block bladder cancer progression: a study based on network pharmacology, in vitro and in vivo assays [0.03%]
网络药理学及体内外实验表明黄连素通过调节PI3K／AKT信号通路抑制膀胱癌进展
Yu Xiaohui,Li Jie,Zhou Jiangqiao
Yu Xiaohui
Background: Coptisine (COP) is a natural compound extracted from Rhizoma Coptidis, and it represses the malignant biological behaviors of bladder cancer cells. However, the underlying molecular mechanism has not been full...
Bioinformatics-based study on the regulatory network of lipid metabolism-related genes and mechanisms in coronary heart disease [0.03%]
基于生物信息学的冠心病脂代谢相关基因及调控网络机制研究
Zunxiong Xiao,Liping Wang,Haoqing Shao et al.
Zunxiong Xiao et al.
Coronary heart disease (CHD), is a complex cardiovascular disease driven by atherosclerosis, resulting from a dynamic interplay between dysregulated lipid metabolism and chronic inflammation. This study integrates bioinformatics analysis of...
Xin-Liang Zhang,Ying-Qi Zhang,Zhi-Yong Hou et al.
Xin-Liang Zhang et al.
Background: Patients with severe trauma are at high risk of developing life-threatening complications, including acute respiratory failure and circulatory collapse. Extracorporeal membrane oxygenation (ECMO) offers critic...
Review of risk factors and surgical treatment progress for gallbladder cancer [0.03%]
胆囊癌的风险因素及手术治疗进展的评述
Jianguo Feng,Haihong Zhu,Xiaosong Wang
Jianguo Feng
Objective: To systematically review the latest evidence on risk factors and surgical treatment for gallbladder cancer (GBC), with a focus on current controversies and consensus in international guidelines, analyze the app...
RBM15 mediates m6A methylation modification of FOSB mRNA to promote dysfunction of trophoblast cells-a potential link to preeclampsia [0.03%]
RBM15介导FOSB mRNA的m六A甲基化修饰促进滋养细胞功能异常-子痫前期潜在机制研究
Yan Li,Fei Li,Qian Gao
Yan Li
Background: N6-methyladenosine (m6A) methylation modification plays an essential role in the molecular pathogenesis of preeclampsia (PE). This study aimed to explore m6A modification in in vitro PE model, involving RNA bi...
Mapping the global research landscape of mitophagy in Parkinson's disease: a bibliometric and visualization analysis [0.03%]
帕金森病线粒体自噬研究领域的文献计量学及可视化分析
Junqiao Zhao,Qian Wang,Yan Cao et al.
Junqiao Zhao et al.
Parkinson's disease (PD) is closely linked to mitochondrial dysfunction and mitophagy, a key mechanism in PD pathogenesis. However, no dedicated bibliometric analysis of mitophagy in PD exists. This study used data from the Web of Science C...
The diagnostic value of miR-340-5p in pediatric ulcerative colitis and its molecular mechanism by targeting MAP3K2 to modulate intestinal epithelial cell dysfunction [0.03%]
miR-340-5p在儿科溃疡性结肠炎诊断中的价值及其通过靶向MAP3K2调节肠道上皮细胞功能障碍的分子机制
Fanting Meng,Xianlong Han,Lingxia Ge et al.
Fanting Meng et al.
Background: The incidence of pediatric ulcerative colitis (UC) is increasing yearly, and it is urgent to explore precise diagnostic biomarkers and molecular mechanisms. This study aims to investigate the diagnostic value ...