USP8 protects rat-derived H9C2 cardiomyocytes from doxorubicin-triggered ferroptosis and cell death through deubiquitination-mediated stabilization of MDM4 [0.03%]
USP8通过去泛素化介导的MDM4稳定保护大鼠H9C2心肌细胞免受多柔比星触发的铁死亡和细胞死亡
Yixi Li,Xue Yang,Liang Zhang
Yixi Li
Background: Acute heart failure (AHF) is a life-threatening clinical syndrome due to impaired cardiac function. Ferroptosis has emerged as a contributor to cytotoxicity in cardiomyocytes. However, the functional interplay...
TFAP2A promotes NSCLC malignant progression by enhancing AOC1 transcription [0.03%]
TFAP2A通过增强AOC1转录促进非小细胞肺癌恶性进展
Xiang Miao,Hongzhen Zheng,Huimin Mo et al.
Xiang Miao et al.
Background: Non-small cell lung cancer (NSCLC) has high mortality, and patients show variable outcomes and drug responses. Amine oxidase copper-containing 1 (AOC1) is considered an oncogene in many types of tumors. Transc...
Clinical efficacy of acupoint application therapy combined with Kangyou Decoction in treating Helicobacter pylori infection with damp-heat syndrome of the middle Jiao [0.03%]
穴位敷贴联合康幽颗粒治疗肝胃郁热证幽门螺杆菌感染的临床疗效研究
Shang-Ren Xie,Meng-Yi Lv,Jun Yang et al.
Shang-Ren Xie et al.
Background: This study evaluated the clinical efficacy and safety of acupoint application of traditional Chinese medicine (TCM) combined with Kangyou Decoction in patients with Helicobacter pylori (Hp) infection presentin...
Genetic overlap between sarcoidosis and lung cancer: a combined in silico and in vitro approach [0.03%]
肉芽肿性肺病和肺癌的遗传重叠：基于网络和体外实验的方法研究
Sanjukta Dasgupta,Moupiya Ghosh,Subhendu Chakrabarty et al.
Sanjukta Dasgupta et al.
Sarcoidosis patients exhibit an elevated risk of developing lung cancer (LC), suggesting shared genetic and molecular mechanisms between these conditions. This study aimed to identify common differentially expressed genes (DEGs) in sarcoido...
Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson's disease [0.03%]
帕金森病SUMO化修饰标志物的筛选、鉴定及实验验证
Yifo Wei,Xinning Zhang,Rui Zuo et al.
Yifo Wei et al.
Background: Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pa...
Integrating bioinformatics analysis, machine learning, and experimental validation to identify pyroptosis-related genes in the diagnosis of sepsis combined with acute liver failure [0.03%]
结合生物信息学分析、机器学习及实验验证鉴定脓毒症合并急性肝衰竭诊断相关焦亡基因
Jing Yan,Yifeng Pan,Chaoqi Chen et al.
Jing Yan et al.
Background: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role ...
Integrated analysis of gene networks and cellular functions identifies novel heart failure biomarkers [0.03%]
基因网络和细胞功能的综合分析鉴定出新的心力衰竭生物标志物
Jiang Juncheng,Chen Lei,Lin Hao et al.
Jiang Juncheng et al.
Introduction: Heart failure (HF) is a complex clinical condition characterized by impaired cardiac function and progressive structural remodeling. To elucidate the molecular mechanisms driving HF, this study aimed to iden...
Prognostic value of Linc00662/miR-16-5p/FASN in cervical cancer and regulation of tumor progression [0.03%]
Linc00662/miR-16-5p/FASN在宫颈癌中的预后价值及其对肿瘤进展的调控作用
Yu Yang,Zhanping Guo
Yu Yang
Background: Cervical cancer (CC) is the world's single most frequent gynecological cancer, is more than 500,000 new annual cases globally, and is a serious threat to women's reproductive health. LncRNAs have significant e...
Identification and validation of ANXA3 and SOCS3 as biomarkers for acute myocardial infarction related to sphingolipid metabolism [0.03%]
基于鞘脂代谢鉴定和验证急性心肌梗死生物标志物ANXA3和SOCS3
Ling Sun,Lingyan He,Hai-Hua Pan et al.
Ling Sun et al.
Background: Sphingolipid metabolism (SM) is linked to acute myocardial infarction (AMI), but its role remains unclear. This study explored SM-related genes (SMRGs) in AMI to support clinical diagnosis. ...
Structural and functional assessment of TBX20 gene variants in pediatric ventricular septal defect [0.03%]
TBX20基因变异的结构和功能评估在儿童室间隔缺损中的作用
Zhenzhen Qin,Caixia Liu,Jie Wang et al.
Zhenzhen Qin et al.
Objective: This study aimed to investigate the potential role of TBX20 gene variants in the molecular pathogenesis of congenital ventricular septal defect (VSD) in pediatric patients. ...