Shared Genetic Links Between Birth Weight and Developmental-Behavioral Disorders [0.03%]
出生体重与发育行为障碍之间的共享遗传联系
Rongyue Sun,Guosheng Yu,Yanzhao Luo et al.
Rongyue Sun et al.
While observational studies have linked birth weight to developmental-behavioral disorders, establishing genetic correlations and causal relationships remains challenging due to potential confounding factors. In this study, we assessed gene...
Sex-Specific, Intermediate Behavioral Phenotypes in Heterozygous Dopamine Transporter Mutant DAT T356M Mice [0.03%]
多巴胺转运蛋白杂合突变体DAT T356M小鼠的性别特异性行为中间表型
Emma Harris,Krista C Paffenroth,Adriana A Tienda et al.
Emma Harris et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with both genetic and environmental contributions. Previous work identified a de novo mutation in the dopamine transporter (DAT T356M) in an autism proband that result...
Spatiotemporal Patterns of Gene Expression Associated With Mating Stimuli in the Brain of Female Guppies [0.03%]
关于剑尾鱼大脑中与交配刺激相关的时空基因表达模式
Amaury Bittar,Catalina Botia,Santiago Martínez et al.
Amaury Bittar et al.
Investigating the spatiotemporal patterns of gene expression in the brain is a critical step toward unraveling the molecular mechanisms underlying social behavior. While significant progress has been made in identifying neurogenomic states ...
Genome-Wide Association Study of Cognitive Function in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study [0.03%]
基于日本队列的大规模人口基因组关联研究揭示认知功能的遗传基础：东北医疗Megabank项目脑磁共振成像子项目
Genki Shinoda,Taku Obara,Ippei Takahashi et al.
Genki Shinoda et al.
Heritability of cognitive function is estimated to be 50%-80%. Genome-wide association studies (GWASs) have identified multiple cognitive function-associated loci, primarily in the European population. However, those in Asian populations, p...
Metabolic and Inflammatory Stimuli Impact Vascular Circulation and Cell Proliferation Processes in the Amygdala [0.03%]
代谢和炎症刺激影响杏仁核血管循环和细胞增殖过程
Sreelaya Bhamidi,Gloria R Sunderland,Bruce R Southey et al.
Sreelaya Bhamidi et al.
The amygdala participates in the processing of stimulus signals from stimuli and the coordination of the physiological and behavioral responses. The sexually dimorphic structure of the amygdala also contributes to sex-specific molecular and...
Dapagliflozin Reverses LPS-Induced Depressive-Like Behavior in Mice via Modulation of Glutamate and NF-κB [0.03%]
dapagliflozin通过调节谷氨酸和NF-κB逆转LPS诱导的小鼠类似抑郁行为
Haneen Amawi,Sahar Alsheyab,Alaa M Hammad et al.
Haneen Amawi et al.
Major depressive disorder is a prevalent and debilitating psychiatric illness that produces significant disability. Clinical data suggest that the pathophysiology of depression is due, in part, to a dysregulation of inflammation and glutama...
Sex-Specific Behavioral Features of Juvenile and Adult Haploinsufficient Scn2a+/- Female Mice, Model of Autism Spectrum Disorder [0.03%]
少剂量SCN2A基因敲除雌鼠（自闭症模型）的行为表型研究：幼年期与成年期的性别差异特征
Wendy Marcantonio,Martina Simonti,Isabelle Léna et al.
Wendy Marcantonio et al.
Genetic variants of the SCN2A gene, encoding the NaV1.2 sodium channel, cause a spectrum of neurodevelopmental and epileptic disorders, and are among those that show the strongest association with Autism Spectrum Disorder (ASD). ASD has a m...
Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study [0.03%]
青少年行为和认知发展研究中儿童延迟折扣和冲动人格特征的全基因组关联研究
Wei Q Deng,Mahmoud Elsayed,Kyla L Belisario et al.
Wei Q Deng et al.
Impulsivity, often operationalized as delay discounting (DD) and as impulsive personality traits via the UPPS-P scales, is a key transdiagnostic construct across psychiatric disorders. Recent genome-wide association studies (GWAS) have stud...
Training Schedule Affects Operant Responding Independent of Motivation in the Neuroligin-3 R451C Mouse Model of Autism [0.03%]
训练时间会影响自闭症啮齿动物模型Neuroligin-3 R451C的 operant 行为独立于动机之外
Riki Dingwall,Carlos May,Jackson A McDonald et al.
Riki Dingwall et al.
Autism affects ~1 in 100 people and arises from the interplay between rare genetic changes and the environment. Diagnosis is based on social and communication difficulties, as well as the presence of restricted and repetitive behaviours. Au...
Simultaneous RNA Sequencing and DNA Methylation Profiling Reveals Neural Mechanisms That Regulate Sensitive Period Behavioral Learning [0.03%]
同时进行RNA测序和DNA甲基化分析可揭示调控敏感期行为学习的神经机制
Sarah E London,Mark E Hauber,Matthew I McKim-Louder et al.
Sarah E London et al.
Developmental processes emerge from both maturational and experience-dependent mechanisms. Experience at the proper maturational stage is essential for the acquisition of many complex cognitive and behavioral processes. A striking example o...