Early allograft dysfunction in a pediatric liver allograft with an occult pathogenic mutation in the urea cycle [0.03%]
尿素循环隐性致病突变供肝的儿童肝脏移植术后早期移植物功能障碍
Milad Rezvani,Kathleen M Campbell,Carlos E Prada et al.
Milad Rezvani et al.
Liver transplantation risks transferring a genetic defect in metabolic pathways, including the urea cycle. We present a case of pediatric liver transplantation complicated by metabolic crisis and early allograft dysfunction (EAD) in a previ...
Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices [0.03%]
活体肾脏捐献者的基因评价：综述及最佳实践建议
Christie P Thomas,Reem Daloul,Krista L Lentine et al.
Christie P Thomas et al.
The growing accessibility and falling costs of genetic sequencing techniques has expanded the utilization of genetic testing in clinical practice. For living kidney donation, genetic evaluation has been increasingly used to identify genetic...
Engineering pancreatic islets with a novel form of thrombomodulin protein to overcome early graft loss triggered by instant blood-mediated inflammatory reaction [0.03%]
工程化胰岛以克服由瞬时血源性炎症反应引发的早期移植物丢失的新方法——应用一种新型纤溶酶原激活物抑制剂2蛋白型组织型 thrombomodulin
Ali Turan,Lei Zhang,Mohammad Tarique et al.
Ali Turan et al.
The instant blood-mediated inflammatory reaction (IBMIR) is initiated by innate immune responses that cause substantial islet loss after intraportal transplantation. Thrombomodulin (TM) is a multifaceted innate immune modulator. In this stu...
Heart-liver-kidney transplantation for AL amyloidosis using normothermic recovery and storage from a donor following circulatory death: Short-term outcome in a first-in-world experience [0.03%]
循环死亡供者常温机体制备和保存心脏、肝脏和肾脏用于治疗淀粉样变病的移植手术：世界首例短期随访结果报告
Aleah L Brubaker,Marcus A Urey,Raeda Taj et al.
Aleah L Brubaker et al.
AL amyloidosis is a rare condition characterized by the overproduction of an unstable free light chain, protein misfolding and aggregation, and extracellular deposition that can progress to multiorgan involvement and failure. To our knowled...
BK DNAemia and native kidney polyomavirus nephropathy following lung transplantation [0.03%]
肺移植后BK病毒血症和原发性肾脏_polyoma_病毒感染肾病
Geoffrey K Dube,Ibrahim Batal,Lori Shah et al.
Geoffrey K Dube et al.
BK virus DNAemia (BKPyV) and nephropathy are common after kidney transplant; however, there are limited data on BK infections in nonrenal solid organ transplant recipients. We examined the frequency, clinical and pathologic features, and ki...
Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival [0.03%]
共生肠道菌Alistipes onderdonkii口服给药可延长同种异体移植物存活率
Zhipeng Li,Mladen Rasic,Montserrat Kwan et al.
Zhipeng Li et al.
Intestinal commensals can exert immunomodulatory effects on the host, with beneficial or detrimental consequences depending on underlying diseases. We have previously correlated longer survival of minor mismatched skin grafts in mice with t...
Mortality among solid organ transplant recipients with a pretransplant cancer diagnosis [0.03%]
移植前患有癌症的实体器官移植受者的死亡率
Allyson Hart,Ruth M Pfeiffer,Bozena M Morawski et al.
Allyson Hart et al.
Little is known about the outcomes among solid organ transplant recipients with a pretransplant cancer diagnosis. We used linked data from the Scientific Registry of Transplant Recipients with 33 US cancer registries. Cox proportional hazar...
Lymphopenia at the time of transplant is associated with short-term mortality after deceased donor liver transplantation [0.03%]
移植时淋巴细胞减少与尸体肝移植后的短期死亡率相关
Toshihiro Kitajima,Luckshi Rajendran,Eric Lisznyai et al.
Toshihiro Kitajima et al.
Absolute lymphocyte count (ALC) is considered a surrogate marker for nutritional status and immunocompetence. We investigated the association between ALC and post-liver transplant outcomes in patients who received a deceased donor liver tra...
The living kidney donor profile index fails to discriminate allograft survival: implications for its use in kidney paired donation programs [0.03%]
供者预后指数无法预测肾脏移植的存活率：其在交换捐献中的应用受限
Georgina L Irish,Lachlan C McMichael,Matthew Kadatz et al.
Georgina L Irish et al.
The inclusion of blood group- and human leukocyte antigen-compatible donor and recipient pairs (CPs) in kidney paired donation (KPD) programs is a novel strategy to increase living donor (LD) transplantation. Transplantation from a donor wi...
Endothelial phosphoinositide 3-kinase-β inactivation confers protection from immune-mediated vascular injury [0.03%]
内皮细胞磷脂酰肌醇-3-激酶-β失活对免役介导的血管损伤具有保护作用
Andrew G Masoud,Jiaxin Lin,Lin F Zhu et al.
Andrew G Masoud et al.
Heart transplant and recipient survival are limited by immune cell-mediated injury of the graft vasculature. We examined the role of the phosphoinositide 3-kinase-β (PI3Kβ) isoform in endothelial cells (EC) during coronary vascular immune...