LUNG TRANSPLANTATION AFTER PROLONGED TA-NRP IN COMBINED HEART-LUNG PROCUREMENT FROM CONTROLLED DCD DONORS IN ITALY [0.03%]
意大利控制性DCD供体心肺联合获取后长期体外膜肺支持的受者序贯式肺移植
Vincenzo Verzeletti,Alessandro Palleschi,Filippo Antonacci et al.
Vincenzo Verzeletti et al.
Thoraco-abdominal normothermic regional perfusion(TA-NRP) is an emerging strategy for heart recovery in controlled donation after circulatory death(cDCD). Its impact on lung graft retrieval remains debated, especially regarding the duration...
Tubule-Derived GDF15 Limits Renal Transplant Injury by Reprogramming Macrophage Responses [0.03%]
导管衍生的GDF15通过重新编程巨噬细胞反应限制肾移植损伤
Lang Shi,Sen Zhou,Juan Zhao et al.
Lang Shi et al.
Kidney transplantation remains the gold standard for end-stage renal disease, but ischemia-reperfusion injury (IRI) and delayed graft function (DGF) continue to hinder outcomes. Growth differentiation factor 15 (GDF15), a stress-responsive ...
Economic Benefits of T-cell-depleting Induction in Deceased Donor Kidney Transplant Recipients [0.03%]
接受尸体器官移植的肾病患者采用T细胞耗竭诱导法带来的经济效益分析研究
David Axelrod,Krista L Lentine,Huiling Xiao et al.
David Axelrod et al.
Thymoglobulin (TMG) induction improves long-term outcomes in high-immunologic-risk kidney transplant (KTx) by reducing acute cellular rejection. However, routine use of TMG in lower-immunologic-risk KTx is controversial, given concerns abou...
Lack of Association Between Donor Left Ventricular Hypertrophy and Graft Survival in the Contemporary Era of Heart Transplantation [0.03%]
供者左心室肥厚与当代心脏移植受者生存之间的无关性研究
Jamal H Mahar,Brian Wayda,Yingjie Weng et al.
Jamal H Mahar et al.
Donor heart left ventricular hypertrophy (LVH) is a common reason for organ discard in the U.S., despite limited contemporary data on its impact on transplant outcomes. Using Scientific Registry of Transplant Recipients data (2015-2022), we...
Oral tributyrin supplementation induces Treg-mediated immune regulation and prolongs allograft survival in preclinical transplant models [0.03%]
口服全氟丁酸补充诱导Treg介导的免疫调节并延长移植模型的移植物存活时间
Daniel M Mendes,João I B Gonçalves,Kaifeng Liu et al.
Daniel M Mendes et al.
Immunosuppressive drugs remain essential for preventing rejection but carry significant toxicities, underscoring the need for safer, physiology-based immunomodulators. Tributyrin, a prodrug of butyrate with improved systemic bioavailability...
Exhausted/Senescent CD4+ T cells as Predictors of Vaccine Failure and Severe COVID-19 in Solid Organ Transplant Recipients [0.03%]
实体器官移植受者中耗竭/衰老的CD4+T细胞是疫苗无效和严重COVID-19疾病的预测因素
Laura Donadeu,Franc Casanova-Ferrer,Susana Gomez-Olles et al.
Laura Donadeu et al.
Despite booster vaccinations, solid organ transplants (SOT) develop suboptimal immunity and remain at risk of severe COVID-19. Chronic immunosuppression and repeated antigen exposure favors T-cell exhaustion/senescence, potentially challeng...
Spiroplasma infection complicated by macrophage activation syndrome and fulminant hepatitis in a kidney transplanted patient [0.03%]
肾脏移植患者螺旋体感染并发巨噬细胞活化综合征和急性肝功能衰竭病例报告
Imane Farhat,Hannah Kaminski,Pierre Louis Woerther et al.
Imane Farhat et al.
A 65-year-old kidney transplant recipient was admitted with isolated fever. Initial tests revealed pancytopenia and elevated C-reactive protein levels but failed to detect any pathogen. A bone marrow aspirate was performed because of signs ...
Christophe Masset,Olivia Rousseau,Alexandre Walencik et al.
Christophe Masset et al.
Auto-antibodies targeting the angiotensin-II receptor (AT1R-AA) have been identified as drivers of allograft vascular inflammation in kidney transplantation. We investigated the role of AT1R-AA in pancreas transplantation with focus on reje...
Rewriting the rule of alloimmunity: a blueprint for B cell-driven transplant outcomes [0.03%]
重写allo免疫的规则：B细胞驱动的移植结果蓝图
Alexandra F Sharland,Natasha M Rogers
Alexandra F Sharland
Occult rat Hepatitis E Virus Infection as a Cause of Cirrhosis and Post-Transplant Recurrence: Insights into the Role of Metagenomics [0.03%]
隐性甲型肝炎E病毒感染致肝硬化和移植术后复发：宏基因组学的作用及启示
Jacques Fourgeaud,Nicolas Veyrenche,Illan Laloum et al.
Jacques Fourgeaud et al.
We report the case of a kidney transplant recipient (2011) who developed persistent elevation of liver enzymes beginning in 2015. Extensive investigations including standard Hepatitis E virus PCR failed to identify a cause. In 2019, she dev...