Neutralizing activity and 3-month durability of tixagevimab and cilgavimab prophylaxis against Omicron sublineages in transplant recipients [0.03%]
移植受者中替沙吉单抗和西加利单抗的预防作用对奥密克戎亚系的中和活性和三个月的持续时间
Andrew H Karaba,Jake D Kim,Teresa P-Y Chiang et al.
Andrew H Karaba et al.
Neutralizing antibody (nAb) responses are attenuated in solid organ transplant recipients (SOTRs) despite severe acute respiratory syndrome-coronavirus-2 vaccination. Preexposure prophylaxis (PrEP) with the antibody combination tixagevimab ...
Addressing sex-based disparities in solid organ transplantation in the United States - a conference report [0.03%]
美国固体器官移植性别差异研讨会报告
Deirdre Sawinski,Jennifer C Lai,Sean Pinney et al.
Deirdre Sawinski et al.
Solid organ transplantation provides the best treatment for end-stage organ failure, but significant sex-based disparities in transplant access exist. On June 25, 2021, a virtual multidisciplinary conference was convened to address sex-base...
Anatomical variations of left hepatic vein and outflow reconstruction techniques in pediatric living donor liver transplantation [0.03%]
儿童活体肝移植中左肝静脉变异及流出道重建技巧
Sadhana Shankar,Ashwin Rammohan,Vasanthakumar Gunasekaran et al.
Sadhana Shankar et al.
Anatomical variations of left hepatic vein are observed in nearly a third of left lateral segment (LLS) donors in living donor liver transplantation. However, there is a paucity of studies and no structured algorithm for customized outflow ...
Successful living donor liver transplantation in a patient with hemophilia A and factor VIII inhibitor: A case report with perioperative recommendations [0.03%]
A型血友病伴第八因子抑制物活体肝移植一例并术前术后处理建议报告
Reed W Kamyszek,Suman L Sood,Christopher J Sonnenday et al.
Reed W Kamyszek et al.
Liver transplantation in patients with end-stage liver disease and coexisting hemophilia A has been described. Controversy exists over perioperative management of patients with factor VIII inhibitor predisposing patients to hemorrhage. We d...
Temporal changes in the utilization of kidneys from hepatitis C virus-infected donors in the United States [0.03%]
美国HCV阳性供肾利用的年代变化特征分析
Keri-Ann Buchanan-Peart,Javier Pagan,Eric Martin et al.
Keri-Ann Buchanan-Peart et al.
Despite data demonstrating increased utilization of kidneys from hepatitis C virus (HCV)-infected donors, it is unknown whether this is due to an increase in the donor pool or improved organ utilization and whether data from early pilot tri...
Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity [0.03%]
强制性的肠道归巢的调节性T细胞减少了早期移植物抗宿主病的严重程度
Jemma H Larson,Sujeong Jin,Michael Loschi et al.
Jemma H Larson et al.
Damage to the gastrointestinal tract following allogeneic hematopoietic stem cell transplantation is a significant contributor to the severity and perpetuation of graft-versus-host disease. In preclinical models and clinical trials, we show...
Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates [0.03%]
CXCR4结合和蛋白酶体抑制对HLA致敏肾移植供者骨髓浆细胞的体内影响
Amy P Rossi,Simon Tremblay,Cyd M Castro-Rojas et al.
Amy P Rossi et al.
To date, plasma cell (PC)-targeted therapies have been limited by suboptimal PC depletion and antibody rebound. We hypothesized this is partly because of PC residence in protective bone marrow (BM) microenvironments. The purpose of this pro...
The importance of avoiding time-dependent bias when testing the prognostic value of an intervening event - Two acute cellular rejection examples in intestinal transplantation [0.03%]
避免在检验干预事件的预后价值时产生时间依赖偏倚的重要性——两个肠道移植急性细胞排斥反应的例子
Jeffrey J Gaynor,Marina M Tabbara,Gaetano Ciancio et al.
Jeffrey J Gaynor et al.
In testing the prognostic value of the occurrence of an intervening event (clinical event that occurs posttransplant), 3 proper statistical methodologies for testing its prognostic value exist (time-dependent covariate, landmark, and semi-M...
The evolving use of biomarkers in heart transplantation: Consensus of an expert panel [0.03%]
心移植中生物标志物应用的演变：专家共识
Jon Kobashigawa,Shelley Hall,Palak Shah et al.
Jon Kobashigawa et al.
In heart transplantation, the use of biomarkers to detect the risk of rejection has been evolving. In this setting, it is becoming less clear as to what is the most reliable test or combination of tests to detect rejection and assess the st...