High BMI at Liver Transplantation: A Retrospective Single-Center Analysis of Blood Product Utilization and Postoperative Outcomes [0.03%]
移植时体重指数较高：单中心回顾性分析血制品使用和术后结局
Sebastian Zeiner,Rishi P Kothari,Mallika Reddy et al.
Sebastian Zeiner et al.
Obesity, generally defined as High BMI is increasingly prevalent in liver transplant recipients, but its impact on perioperative management is still not understood. This study examined intraoperative transfusion as a marker of surgical comp...
Donor Heart Preservation at 10°C After Thoracoabdominal Normothermic Regional Perfusion Lowers Rates of Severe Primary Graft Dysfunction and Improves Recipient Transplant Outcomes [0.03%]
经胸腹主动脉局部区域灌注后在10℃下保存供体心脏可降低严重原发性移植物功能障碍发生率并改善移植预后
Aaron M Williams,John M Trahanas,Awab Ahmad et al.
Aaron M Williams et al.
This study compares a novel static cold storage (SCS) method using 10°C preservation to conventional ice following thoracoabdominal normothermic regional perfusion (TA-NRP) in donation after circulatory death (DCD) heart transplantation. W...
Suppression of Cardiac Allograft Vasculopathy by a Macrophage Efferocytosis Receptor [0.03%]
巨噬细胞亡细胞摄取受体抑制心脏移植物血管病
Sahil Shah,Aparnaa Ananthakrishnan,Matthew DeBerge et al.
Sahil Shah et al.
Cardiac allograft vasculopathy remains a major cause of late morbidity following heart transplantation. While accumulating evidence implicates innate macrophages in the inflammatory progression of CAV, the underlying mechanisms remain incom...
Sacubitril suppresses experimental chronic heart allograft vasculopathy [0.03%]
Sacubitril抑制实验性慢性心脏移植物血管病的发展
Andrew G Masoud,Kolden van Baar,Lin Fu Zhu et al.
Andrew G Masoud et al.
Chronic allograft vasculopathy (CAV) limits graft and recipient survival after heart transplantation despite modern immune suppression. We examined the effect of sacubitril, an inhibitor of neprilysin neutral endopeptidase activity, on prog...
Tolerogenic Lung Allograft Microenvironment Suppresses Pathogenic Tissue Remodeling Following Respiratory Virus Infection in Mice [0.03%]
小鼠呼吸道病毒感染后耐受性肺移植微环境可抑制病理性组织重塑
Italo Araujo Castro,Yuriko Terada,Yuhei Yokoyama et al.
Italo Araujo Castro et al.
Tolerance after lung transplantation is associated with the induction of Foxp3+ regulatory T cell-enriched bronchus-associated lymphoid tissue, which suppresses local and systemic alloimmune responses. How this tolerogenic graft environment...
Organ Procurement and Transplantation Network infrastructure: a high value investment for the government [0.03%]
器官获取和移植网络基础设施：政府的高价值投资
S B Klitenic,B Sullivan,M L Levan et al.
S B Klitenic et al.
Improving the histologic detection of DSA-negative antibody-mediated rejection in kidney transplants [0.03%]
改善肾移植中DSA阴性抗体介导的排斥反应的组织学检测
Luis G Hidalgo,Katelynn S Madill-Thomsen,Jeff Reeve et al.
Luis G Hidalgo et al.
Emerging treatments for antibody-mediated rejection (ABMR, NEJM391(2):122-132) have increased the importance of ABMR detection when donor-specific antibody (DSA) is negative. We addressed this issue in the Trifecta-Kidney study (ClinicalTri...
Targeting the Alternative Complement Pathway by Iptacopan Abrogates C3 and Strongly Reduces C5b-9 Deposition within Glomeruli in IgA Nephropathy Recurrence after Kidney Transplantation [0.03%]
靶向补体替代途径的Iptacopan抑制IgA肾病移植后的C3和C5b-9沉积
Enrico Sanna,Silvia Rita Nicassio,Alberto Mella et al.
Enrico Sanna et al.
Current trials are exploring complement blockade in IgA nephropathy (IgAN) of native kidneys. No data are available on IgAN recurrence. Herein, we report on the first small case series (n = 5) treated with iptacopan, a factor B inhibitor ta...
Sumit Mohan,Riya Lahiri,Eugene Lin
Sumit Mohan
Landscape of subclinical rejection in a large international cohort of pediatric kidney transplant (kTx) recipients [0.03%]
儿童肾移植受者的亚临床排斥的现状（一项国际多中心研究）
Julien Hogan,Rouba Garro,Charlotte Duneton et al.
Julien Hogan et al.
Kidney allograft rejection occurs in clinically stable patients, but its long-term significance in children is unknown. Previous studies demonstrated that subclinical inflammation is associated with an increased risk of rejection. However, ...