Autoantibodies against DNA topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses [0.03%]
抗DNA拓扑异构酶I自身抗体通过增加allo反应性T细胞的免疫应答促进同种肾移植排斥反应
Victoria Gorbacheva,Ran Fan,Satoshi Miyairi et al.
Victoria Gorbacheva et al.
Antibodies reactive to self-antigens are an important component of posttransplant immune responses. The generation requirements and functions of autoantibodies, as well as the mechanisms of their influence on alloimmune responses, still rem...
Induced regulatory T cells modified by knocking down T-bet in combination with ectopic expression of inhibitory cytokines effectively protect graft-versus-host disease [0.03%]
T-bet基因敲低诱导的调节性T细胞联合外源性抑制性细胞因子表达有效防治移植物抗宿主病
Rongrong Gao,Ang Li,Sen Li et al.
Rongrong Gao et al.
Induced regulatory T (iTreg) cells play a vital role in immune tolerance and in controlling chronic inflammation. Generated in the periphery, iTreg cells are suitable for responding to alloantigens and preventing transplant rejection. Never...
Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells [0.03%]
佐剂条件诱导通过髓样衍生的抑制细胞增殖产生免疫抑制环境从而延迟alloislet排斥反应
Jifu Ge,Weikang Pan,Noel J Feeney et al.
Jifu Ge et al.
Advances in immunosuppression have been relatively stagnant over the past 2 decades, and transplant recipients continue to experience long-term morbidity associated with immunosuppression regimens. Strategies to reduce or eliminate the dosa...
Competing risk methods for waiting list outcomes: a context-specific gold standard [0.03%]
竞争风险方法用于等待名单结局的评估：一个特定背景下的金标准
Darren Stewart
Darren Stewart
The tele-liver frailty index (TeLeFI): development of a novel frailty tool in patients with cirrhosis via telemedicine [0.03%]
基于远程医疗的肝硬化患者新型衰弱评估工具-TeleFI（远程肝脏衰弱指数）的构建与发展
Melinda Wang,Amy M Shui,Fawzy Barry et al.
Melinda Wang et al.
Frailty is a critical determinant of outcomes in cirrhosis patients. The increasing use of telemedicine has created an unmet need for virtual frailty assessment. We aimed to develop a telemedicine-enabled frailty tool (tele-liver frailty in...
Achievement of operational tolerance in a pediatric liver transplant recipient following successful hematopoietic stem cell transplantation from a different donor [0.03%]
一名儿科肝移植受者在成功接受不同供者的造血干细胞移植后实现操作耐受性
Mattia Algeri,Enrico Velardi,Marco Spada et al.
Mattia Algeri et al.
Hematopoietic stem cell transplantation (HSCT)-based approaches are increasingly investigated strategies to induce tolerance in recipients of solid allografts. However, in the majority of cases, these approaches rely on the infusion of hema...
Alleviating graft-versus-host disease by directing regulatory T cells to the gut … It is all about location, location, location [0.03%]
特异定位诱导调节性T细胞防治移植物抗宿主病——位置，位置，还是位置！
Manjurul Haque,Dominic A Boardman,Megan K Levings
Manjurul Haque
Epidemiology, management, and clinical outcomes of extrapulmonary Mycobacterium abscessus complex infections in heart transplant and ventricular assist device recipients [0.03%]
心脏移植和心室辅助装置接受者中鸟分枝杆菌复合体的肺外感染的流行病学、管理和临床结局
Anne E Friedland,Eileen K Maziarz,Cameron R Wolfe et al.
Anne E Friedland et al.
Nontuberculous mycobacteria are emerging pathogens, yet data on the epidemiology and management of extrapulmonary nontuberculous mycobacteria infections in orthotopic heart transplantation (OHT) and ventricular assist device (VAD) recipient...
Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses [0.03%]
猪内皮细胞源性外泌体的异种识别和共刺激作用在启动人特异性T细胞免疫反应中的作用
Shu Li,Imran J Anwar,Aidan J Canning et al.
Shu Li et al.
Porcine vascular endothelial cells (PECs) form a mechanistic centerpiece of xenograft rejection. Here, we determined that resting PECs release swine leukocyte antigen class I (SLA-I) but not swine leukocyte antigen class-II DR (SLA-DR) expr...
Competitive binding of CD226/TIGIT with poliovirus receptor regulates macrophage polarization and is involved in vascularized skin graft rejection [0.03%]
CD226/TIGIT与多瘤病毒受体的竞争结合调节巨噬细胞极化并参与带血管皮肤移植排斥反应
Dongliang Zhang,Yitian Liu,Jingchang Ma et al.
Dongliang Zhang et al.
End-stage organ failure often requires solid organ transplantation. Nevertheless, transplant rejection remains an unresolved issue. The induction of donor-specific tolerance is the ultimate goal in transplantation research. In this study, a...