Induced pluripotent stem cell-derived hematopoietic stem and progenitor cells induce mixed chimerism and donor-specific allograft tolerance [0.03%]
诱导多能干细胞来源的造血干/祖细胞可诱导混合嵌合和同种异体移植物耐受
Tomoki Murata,Naoki Hama,Tomoki Kamatani et al.
Tomoki Murata et al.
In transplantation using allogeneic induced pluripotent stem cells (iPSCs), strategies focused on major histocompatibility complexes were adopted to avoid immune rejection. We showed that minor antigen mismatches are a risk factor for graft...
Lara C Pullen
Lara C Pullen
Klemens Budde,Bruce Kaplan
Klemens Budde
Demystifying tolerance [0.03%]
揭秘容差
Kenneth A Newell
Kenneth A Newell
Rachel A Davis,Tyler Branagan,Christopher D Schneck et al.
Rachel A Davis et al.
Nearly 10 000 people are removed from the kidney transplant waiting list each year either due to becoming too ill for transplant or due to death. Live donor kidney transplant (LDKT) provides superior outcomes and survival benefit relative t...
Autoantibodies as drivers of T-cell-mediated allograft rejection: The plot thickens [0.03%]
自身抗体在T细胞介导的同种异体移植排斥中的作用：谜团加深
Emmanuel Zorn
Emmanuel Zorn
The limitation of using procurement biopsy findings in the assessment of deceased donor kidney quality and outcomes [0.03%]
活体捐赠者肾脏质量及预后的评估中使用采购活检结果的局限性
Pooja Budhiraja,Raymond Heilman,Byron H Smith et al.
Pooja Budhiraja et al.
Rapamycin antagonizes angiogenesis and lymphangiogenesis through myeloid-derived suppressor cells in corneal transplantation [0.03%]
雷帕霉素通过髓系来源的抑制细胞对抗新生血管和淋巴管生成以促进角膜移植耐受性
Yuerong Ren,Xiaonan Dong,Yingyi Liu et al.
Yuerong Ren et al.
Rapamycin is an immunosuppressive drug that is widely used in the postsurgery management of transplantation. To date, the mechanism by which rapamycin reduces posttransplant neovascularization has not been fully understood. Given the origin...
Lung transplantation despite preformed donor-specific antihuman leukocyte antigen antibodies: a 9-year single-center experience [0.03%]
预存人白细胞抗原特异性抗体受者的肺移植：单中心9年经验
Emma L Heise,Evgeny Chichelnitskiy,Mark Greer et al.
Emma L Heise et al.
Pretransplant allosensitization to human leukocyte antigens (HLA) increases the recipient's waiting list time and mortality in lung transplantation. Rather than waiting for crossmatch-negative donors, since 2013, recipients with preformed d...
Therapeutic reconditioning of damaged lungs by transient heat stress during ex vivo lung perfusion [0.03%]
体外肺灌注中短暂热应力对受损肺的治疗重塑作用
Amaia Ojanguren,Roumen Parapanov,Anne Debonneville et al.
Amaia Ojanguren et al.
Ex vivo lung perfusion (EVLP) may serve as a platform for the pharmacologic repair of lung grafts before transplantation (LTx). We hypothesized that EVLP could also permit nonpharmacologic repair through the induction of a heat shock respon...