Defining a natural killer cell-enriched molecular rejection-like state in lung transplant transbronchial biopsies [0.03%]
基于支气管活检的肺移植天然杀伤细胞富集分子排斥状态的定义
Patrick T Gauthier,Martina Mackova,Alim Hirji et al.
Patrick T Gauthier et al.
In lung transplantation, antibody-mediated rejection (AMR) diagnosed using the International Society for Heart and Lung Transplantation criteria is uncommon compared with other organs, and previous studies failed to find molecular AMR (ABMR...
Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics [0.03%]
单细胞转录组学揭示肾脏同种异体移植耐受发展中移植物B细胞分化的调节性B细胞特征签名
Michael Tyler Guinn,Edward S Szuter,Takahiro Yokose et al.
Michael Tyler Guinn et al.
Mouse kidney allografts are spontaneously accepted in select, fully mismatched donor-recipient strain combinations, like DBA/2J to C57BL/6 (B6), by natural tolerance. We previously showed accepted renal grafts form aggregates containing var...
Disseminated vaccine-induced varicella infection in a kidney transplant recipient [0.03%]
肾移植受者中散在的疫苗诱发的水痘感染病例
Megan A Berman,Richard E Rupp
Megan A Berman
A 33-year-old kidney transplant (KT) recipient presented with a disseminated pruritic, painful, vesicular rash and hepatitis 3 weeks after receiving a varicella vaccine (VAR). A skin lesion biopsy sent to the Centers for Disease Control and...
Serkan Sucu,Kerem E Basarir,Plamen Mihaylov et al.
Serkan Sucu et al.
The gut microbiota has been gaining attention due to its interactions with the human body and its role in pathophysiological processes. One of the main interactions is the "gut-liver axis," in which disruption of the gut mucosal barrier see...
The role of interleukin-21 in COVID-19 vaccine-induced B cell-mediated immune responses in patients with kidney disease and kidney transplant recipients [0.03%]
IL-21在肾病和肾移植受者中的作用：新冠疫苗诱导的B细胞介导免疫反应研究
S Reshwan K Malahe,Yvette den Hartog,Wim J R Rietdijk et al.
S Reshwan K Malahe et al.
T-cell-mediated help to B cells is required for the development of humoral responses, in which the cytokine interleukin (IL)-21 is key. Here, we studied the mRNA-1273 vaccine-induced SARS-CoV-2-specific memory T-cell IL-21 response, memory ...
Siplizumab combination therapy with belatacept or abatacept broadly inhibits human T cell alloreactivity in vitro [0.03%]
西利珠单抗与贝拉妥尤单抗或阿巴西普联合治疗可体外广谱抑制人T细胞移植物抗宿主病反应
Filip Cvetkovski,Ronia Razavi,Felix Sellberg et al.
Filip Cvetkovski et al.
Combined antigen-specific T cell receptor stimulation and costimulation are needed for complete T cell activation. Belatacept and abatacept are nondepleting fusion proteins blocking CD28/B7 costimulation, whereas siplizumab is a depleting a...
Eculizumab as a therapeutic approach for severe crescentic recurrence of immunoglobulin A nephropathy after kidney transplantation [0.03%]
补体抑制剂依库珠单抗治疗肾移植后重症新月体形成性IgA肾病复发的有效性和安全性
Anna Duval,Jérôme Olagne,Augustin Obrecht et al.
Anna Duval et al.
Crescentic forms of immunoglobulin A nephropathy (IgAN) are rare but can be associated with rapid kidney failure and a high rate of end-stage renal disease despite immunosuppression therapy. Complement activation has emerged as a key driver...
Robert J Stratta,Colleen L Jay
Robert J Stratta
Impact of allele-specific anti-human leukocyte antigen class I antibodies on organ allocation [0.03%]
特异性抗人类白细胞抗原抗体对器官分配的影响
Melissa Y Yeung,Naoka Murakami,Maria L Kafetzi et al.
Melissa Y Yeung et al.
Technological advances in the field of histocompatibility have allowed us to define anti-human leukocyte antigen (HLA) antibody specificity at the allelic level. However, how allele-specific antibodies affect organ allocation is poorly stud...
Tomás Blanco,Aytan Musayeva,Rohan Bir Singh et al.
Tomás Blanco et al.
Corneal transplantation is the most common form of solid tissue grafting, with an approximately 80% to 90% success rate. However, success rates may decline when donor tissues are derived from patients with a history of diabetes mellitus (DM...