Electronic health record-enabled routine assessment of medication adherence after solid organ transplantation: the time is now [0.03%]
电子健康记录启用实体器官移植后常规药物依从性评估的时机已经成熟
Abbie D Leino,Tiffany E Kaiser,Karen Khalil et al.
Abbie D Leino et al.
Medication nonadherence after solid organ transplantation is recognized as an important impediment to long-term graft survival. Yet, assessment of adherence is often not part of routine care. In this Personal Viewpoint, we call for the tran...
Is it time to reconsider universal severe acute respiratory syndrome coronavirus 2 polymerase chain reaction screening for asymptomatic potential nonlung solid organ transplant donors? [0.03%]
是否应重新考虑对无症状潜在非肺实体器官捐献者进行普遍的严重急性呼吸系统综合征冠状病毒2型聚合酶链反应筛查？
Yoichiro Natori,Shweta Anjan,Jonathan Hand
Yoichiro Natori
Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity [0.03%]
低亲和性CD8+ T细胞提供细胞间帮助提高高亲和性CD8+ T细胞的同种免疫反应
Peter Wang,Luqiu Chen,Ricardo Mora-Cartin et al.
Peter Wang et al.
Following solid organ transplantation, small precursor populations of polyclonal CD8+ T cells specific for any graft-expressed antigen preferentially expand their high-affinity clones. This phenomenon, termed "avidity maturation," results i...
Atezolizumab plus bevacizumab as a downstaging therapy for liver transplantation in hepatocellular carcinoma with portal vein thrombosis: The first report [0.03%]
阿特珠单抗联合贝伐珠单抗作为门静脉血栓肝细胞癌肝脏移植降期治疗的首次报道
Pramod Kumar,Pradeep Krishna,Ravindra Nidoni et al.
Pramod Kumar et al.
Atezolizumab plus bevacizumab is the preferred first-line treatment regimen for patients with advanced hepatocellular carcinoma. Limited data have shown promising results with the use of immune checkpoint inhibitors like nivolumab to downst...
Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection [0.03%]
来自心脏移植血管病拒绝移植物的动脉区域空间多组学揭示了对慢性抗体介导排斥的新见解
Jessica Nevarez-Mejia,Harry Pickering,Rebecca A Sosa et al.
Jessica Nevarez-Mejia et al.
Cardiac allograft vasculopathy (CAV) causes late graft failure and mortality after heart transplantation. Donor-specific antibodies (DSAs) lead to chronic endothelial cell injury, inflammation, and arterial intimal thickening. In this study...
Paolo Cravedi,Leonardo V Riella,Mandy L Ford et al.
Paolo Cravedi et al.
Mouse models have been instrumental in understanding mechanisms of transplant rejection and tolerance, but cross-study reproducibility and translation of experimental findings into effective clinical therapies are issues of concern. The Mou...
Red blood cells as oxygen carrier during normothermic machine perfusion of kidney grafts: Friend or foe? [0.03%]
肾脏移植的常温机械灌注过程中红细胞作为氧气载体的身份：朋友还是敌人？
Asel S Arykbaeva,Lente J S Lerink,Jaël Vos et al.
Asel S Arykbaeva et al.
Renal ex vivo normothermic machine perfusion (NMP) is under development as an assessment tool for high-risk kidney grafts and as a means of achieving more physiologically accurate organ preservation. On-going hemolysis has been reported dur...
Racial disparities across multiple stages of the deceased organ donation process [0.03%]
死者器官捐献过程多个阶段中的种族差异
Raymond C Givens
Raymond C Givens
Pervasive structural violence causes higher organ failure rates among Black Americans and an excess of Black potential deceased organ donors. Underuse of Black donors would exacerbate organ shortages that disproportionately harm Black trans...
Marcus R Pereira
Marcus R Pereira