Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila [0.03%]
果蝇幼虫唾腺细胞中发育程序非依赖性分泌颗粒降解
Tamás Csizmadia,Anna Dósa,Erika Farkas et al.
Tamás Csizmadia et al.
Both constitutive and regulated secretion require cell organelles that are able to store and release the secretory cargo. During development, the larval salivary gland of Drosophila initially produces high amount of glue-containing small im...
Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1-mediated nuclear export [0.03%]
多路复用的细胞分析确定了一种器官硒化合物是CRM1介导的核输出的抑制剂
Lucia Jimenez,Victor Mayoral-Varo,Carlos Amenábar et al.
Lucia Jimenez et al.
Chromosomal region maintenance 1 (CRM1 also known as Xpo1 and exportin-1) is the receptor for the nuclear export controlling the intracellular localization and function of many cellular and viral proteins that play a crucial role in viral i...
An AP-3-dependent pathway directs phagosome fusion with Rab8 and Rab11 vesicles involved in TLR2 signaling [0.03%]
AP-3依赖的途径可指导吞噬溶酶体与参与TLR2信号转导的Rab8和Rab11小泡融合
Tanja Petnicki-Ocwieja,Bijaya Sharma,Urmila Powale et al.
Tanja Petnicki-Ocwieja et al.
Intracellular compartmentalization of ligands, receptors and signaling molecules has been recognized as an important regulator of inflammation. The toll-like receptor (TLR) 2 pathway utilizes the trafficking molecule adaptor protein 3 (AP-3...
Hox-driven conditional immortalization of myeloid and lymphoid progenitors: Uses, advantages, and future potential [0.03%]
HOX基因驱动的髓系和淋巴系祖细胞条件性永生化：用途、优势及未来前景
Shranjit S Lail,Corey R Arnold,Luiz G N de Almeida et al.
Shranjit S Lail et al.
Those who study macrophage biology struggle with the decision whether to utilize primary macrophages derived directly from mice or opt for the convenience and genetic tractability of immortalized macrophage-like cell lines in in vitro studi...
Correction to: Evolution of factors shaping the endoplasmic reticulum [0.03%]
Correction to: 内质网形成因素的进化
Aspasia Kontou,Emily K Herman,Mark C Field et al.
Aspasia Kontou et al.
Published Erratum
Traffic (Copenhagen, Denmark). 2022 Oct;23(10):521. DOI:10.1111/tra.12867 2022
Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes [0.03%]
长链非编码RNA及小细胞外囊泡-长链非编码RNA在2型糖尿病中的作用
Wenguang Chang,Man Wang,Yuan Zhang et al.
Wenguang Chang et al.
The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The patho...
Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis [0.03%]
cdc42 GTP酶活化蛋白Rga4和Rga6在胞质分裂期间协调细胞分裂间隙的隔膜合成及膜转运
Bethany F Campbell,Brian S Hercyk,Ashlei R Williams et al.
Bethany F Campbell et al.
Fission yeast cytokinesis is driven by simultaneous septum synthesis, membrane furrowing and actomyosin ring constriction. The septum consists of a primary septum flanked by secondary septa. First, delivery of the glucan synthase Bgs1 and m...
Byung Hun Lee,Seokyoung Bang,Seung-Ryeol Lee et al.
Byung Hun Lee et al.
Localization of mRNA facilitates spatiotemporally controlled protein expression in neurons. In axons, mRNA transport followed by local protein synthesis plays a critical role in axonal growth and guidance. However, it is not yet clearly und...
A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival [0.03%]
一种由LRRK2/dLRRK介导的溶酶体通路影响胶质细胞凋亡和多巴胺能神经元存活
Linfang Wang,Honglei Wang,Shuanglong Yi et al.
Linfang Wang et al.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease. A plethora of evidence has indicated a role for LRRK2 in endolysosomal trafficking in neurons, while LRRK2 function in...
Aspasia Kontou,Emily K Herman,Mark C Field et al.
Aspasia Kontou et al.
Endomembrane system compartments are significant elements in virtually all eukaryotic cells, supporting functions including protein synthesis, post-translational modifications and protein/lipid targeting. In terms of membrane area the endop...