Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases [0.03%]
神经退行性疾病中病原蛋白聚集体的内吞途径
Pravin Hivare,Kratika Mujmer,Gitanjali Swarup et al.
Pravin Hivare et al.
Endocytosis is the fundamental uptake process through which cells internalize extracellular materials and species. Neurodegenerative diseases (NDs) are characterized by a progressive accumulation of intrinsically disordered protein species,...
Cholangiocytes express an isoform of soluble adenylyl cyclase that is N-linked glycosylated and secreted in extracellular vesicles [0.03%]
胆管细胞表达一种可溶型腺苷酸环化酶异构体，该异构体经N连接型糖基化并在胞外囊泡中分泌
Simei Go,Hang Lam Li,Jung-Chin Chang et al.
Simei Go et al.
Soluble adenylyl cyclase (sAC)-derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels remains underexplored. We consistently observed a 85 kD (sAC85 ) or 75 kD (sAC75 ) sAC protein ...
The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases [0.03%]
细胞外囊泡在铁稳态和铁死亡中的作用：聚焦肌肉骨骼疾病
Zhiwei Liao,Bide Tong,Zixuan Ou et al.
Zhiwei Liao et al.
Iron homeostasis is crucial for maintaining proper cellular function, and its disruption is considered one of the pathogenic mechanisms underlying musculoskeletal diseases. Under conditions of oxidative stress, the accumulation of cellular ...
Syntaxin-5's flexibility in SNARE pairing supports Golgi functions [0.03%]
语法素-5在SNARE配对中的灵活性支持高尔基体的功能
Zinia D&#x;Souza,Irina Pokrovskaya,Vladimir V Lupashin
Zinia D&#x;Souza
Deficiency in the conserved oligomeric Golgi (COG) complex that orchestrates SNARE-mediated tethering/fusion of vesicles that recycle the Golgi's glycosylation machinery results in severe glycosylation defects. Although two major Golgi v-SN...
Lingjie Kong,Shenghao Huang,Yuxuan Bao et al.
Lingjie Kong et al.
Endosomal cargo recycling lies at the heart of subcellular trafficking processes under the management of several Ras-related GTP-binding proteins (Rabs) which are coordinated by their upstream regulators and require their downstream effecto...
Tatiana Burrinha,César Cunha,Michael J Hall et al.
Tatiana Burrinha et al.
Previously, we found that age-dependent accumulation of beta-amyloid is not sufficient to cause synaptic decline. Late-endocytic organelles (LEOs) may be driving synaptic decline as lysosomes (Lys) are a target of cellular aging and relevan...
Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress [0.03%]
假酶STYXL1的缺乏通过内质网应激促进葡糖脑苷脂酶向溶酶体的转运
Saloni Patel,Anshul Milap Bhatt,Priyanka Bhansali et al.
Saloni Patel et al.
Pseudophosphatases are catalytically inactive but share sequence and structural similarities with classical phosphatases. STYXL1 is a pseudophosphatase that belongs to the family of dual-specificity phosphatases and is known to regulate str...
Genetic disruption of mammalian endoplasmic reticulum-associated protein degradation: Human phenotypes and animal and cellular disease models [0.03%]
哺乳动物内质网相关蛋白质降解的遗传干扰：表型与疾病模型
Sally Badawi,Feda E Mohamed,Divya Saro Varghese et al.
Sally Badawi et al.
Endoplasmic reticulum-associated protein degradation (ERAD) is a stringent quality control mechanism through which misfolded, unassembled and some native proteins are targeted for degradation to maintain appropriate cellular and organelle h...
Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages [0.03%]
氧化的胆固醇酯可诱发脂质过多型巨噬细胞中功能异常的溶酶体出胞
Neuza Domingues,André R A Marques,Rita Diogo Almeida Calado et al.
Neuza Domingues et al.
A key event in atherogenesis is the formation of lipid-loaded macrophages, lipidotic cells, which exhibit irreversible accumulation of undigested modified low-density lipoproteins (LDL) in lysosomes. This event culminates in the loss of cel...
Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole [0.03%]
SPI-2依赖的_syntaxin 3_互作促进_沙门氏菌囊泡的分裂
Ritika Chatterjee,Abhilash Vijay Nair,Anmol Singh et al.
Ritika Chatterjee et al.
Intracellular membrane fusion is mediated by membrane-bridging complexes of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). SNARE proteins are one of the key players in vesicular transport. Several reports s...