Syntaxin-5's flexibility in SNARE pairing supports Golgi functions [0.03%]
语法素-5在SNARE配对中的灵活性支持高尔基体的功能
Zinia D&#x;Souza,Irina Pokrovskaya,Vladimir V Lupashin
Zinia D&#x;Souza
Deficiency in the conserved oligomeric Golgi (COG) complex that orchestrates SNARE-mediated tethering/fusion of vesicles that recycle the Golgi's glycosylation machinery results in severe glycosylation defects. Although two major Golgi v-SN...
Lingjie Kong,Shenghao Huang,Yuxuan Bao et al.
Lingjie Kong et al.
Endosomal cargo recycling lies at the heart of subcellular trafficking processes under the management of several Ras-related GTP-binding proteins (Rabs) which are coordinated by their upstream regulators and require their downstream effecto...
Tatiana Burrinha,César Cunha,Michael J Hall et al.
Tatiana Burrinha et al.
Previously, we found that age-dependent accumulation of beta-amyloid is not sufficient to cause synaptic decline. Late-endocytic organelles (LEOs) may be driving synaptic decline as lysosomes (Lys) are a target of cellular aging and relevan...
Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress [0.03%]
假酶STYXL1的缺乏通过内质网应激促进葡糖脑苷脂酶向溶酶体的转运
Saloni Patel,Anshul Milap Bhatt,Priyanka Bhansali et al.
Saloni Patel et al.
Pseudophosphatases are catalytically inactive but share sequence and structural similarities with classical phosphatases. STYXL1 is a pseudophosphatase that belongs to the family of dual-specificity phosphatases and is known to regulate str...
Genetic disruption of mammalian endoplasmic reticulum-associated protein degradation: Human phenotypes and animal and cellular disease models [0.03%]
哺乳动物内质网相关蛋白质降解的遗传干扰：表型与疾病模型
Sally Badawi,Feda E Mohamed,Divya Saro Varghese et al.
Sally Badawi et al.
Endoplasmic reticulum-associated protein degradation (ERAD) is a stringent quality control mechanism through which misfolded, unassembled and some native proteins are targeted for degradation to maintain appropriate cellular and organelle h...
Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages [0.03%]
氧化的胆固醇酯可诱发脂质过多型巨噬细胞中功能异常的溶酶体出胞
Neuza Domingues,André R A Marques,Rita Diogo Almeida Calado et al.
Neuza Domingues et al.
A key event in atherogenesis is the formation of lipid-loaded macrophages, lipidotic cells, which exhibit irreversible accumulation of undigested modified low-density lipoproteins (LDL) in lysosomes. This event culminates in the loss of cel...
Syntaxin 3 SPI-2 dependent crosstalk facilitates the division of Salmonella containing vacuole [0.03%]
SPI-2依赖的_syntaxin 3_互作促进_沙门氏菌囊泡的分裂
Ritika Chatterjee,Abhilash Vijay Nair,Anmol Singh et al.
Ritika Chatterjee et al.
Intracellular membrane fusion is mediated by membrane-bridging complexes of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). SNARE proteins are one of the key players in vesicular transport. Several reports s...
Out of the ESCPE room: Emerging roles of endosomal SNX-BARs in receptor transport and host-pathogen interaction [0.03%]
出逃ESCPE室：内吞体SNX-巴域蛋白在受体转运和宿主病原菌相互作用中的新角色
Boris Simonetti,James L Daly,Peter J Cullen
Boris Simonetti
Several functions of the human cell, such as sensing nutrients, cell movement and interaction with the surrounding environment, depend on a myriad of transmembrane proteins and their associated proteins and lipids (collectively termed "carg...
SWIP mediates retromer-independent membrane recruitment of the WASH complex [0.03%]
SWIP介导了WASH复合物的独立于retromer的膜募集作用
Vojtěch Dostál,Tereza Humhalová,Pavla Beránková et al.
Vojtěch Dostál et al.
The pentameric WASH complex facilitates endosomal protein sorting by activating Arp2/3, which in turn leads to the formation of F-actin patches specifically on the endosomal surface. It is generally accepted that WASH complex attaches to th...
A TRAFFIC themed series - Host membrane trafficking subversion by pathogens [0.03%]
以“交通”为主题的系列文章——病原体对宿主膜转运的劫持与操纵
Eric Chevet,Maria Antonietta De Matteis,Eeva-Liisa Eskelinen et al.
Eric Chevet et al.