Dynamic tandem proximity-based proteomics-Protein trafficking at the proteome-scale [0.03%]
动态邻近依赖串联亲和标签蛋白质组学-蛋白质组尺度上的蛋白质转运
Eric Chevet,Maria Antonietta De Matteis,Eeva-Liisa Eskelinen et al.
Eric Chevet et al.
TransitID is a new methodology based on proximity labeling allowing for the study of protein trafficking a the proteome scale. ...
Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum [0.03%]
疏水性和密码子使用偏倚决定模型K+通道蛋白定位于线粒体或内质网
Anja J Engel,Steffen Paech,Markus Langhans et al.
Anja J Engel et al.
When the K+ channel-like protein Kesv from Ectocarpus siliculosus virus 1 is heterologously expressed in mammalian cells, it is sorted to the mitochondria. This targeting can be redirected to the endoplasmic reticulum (ER) by altering the c...
Statistical modeling of mRNP transport in dendrites: A comparative analysis of β-actin and Arc mRNP dynamics [0.03%]
用于分析细胞突起中β-actin和Arc mRNA运输的统计模型
Hyerim Ahn,Xavier Durang,Jae Youn Shim et al.
Hyerim Ahn et al.
Localization of messenger RNA (mRNA) in dendrites is crucial for regulating gene expression during long-term memory formation. mRNA binds to RNA-binding proteins (RBPs) to form messenger ribonucleoprotein (mRNP) complexes that are transport...
Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7 [0.03%]
Toll样受体正向运输需要载荷分类适配器TMED-2和7
Julia E J Holm,Sandro G Soares,Martyn F Symmons et al.
Julia E J Holm et al.
Toll-Like Receptors (TLRs) play a pivotal role in immunity by recognising conserved structural features of pathogens and initiating the innate immune response. TLR signalling is subject to complex regulation that remains poorly understood. ...
Restoration of β-GC trafficking improves the lysosome function in Gaucher disease [0.03%]
β-GLC转运的恢复可改善戈谢病患者的溶酶体功能
Saloni Patel,Dhwani Radhakrishnan,Darpan Kumari et al.
Saloni Patel et al.
Lysosomes function as a primary site for catabolism and cellular signaling. These organelles digest a variety of substrates received through endocytosis, secretion and autophagy with the help of resident acid hydrolases. Lysosomal enzymes a...
Distinct functional domains of the epsin-related Ent5p, a cargo adaptor for the SNARE Tlg2p in transport between endosomes and Golgi [0.03%]
与SNARE蛋白Tlg2p结合的受体Ent5p（epsin家族成员）在内体和高尔基体之间的转运中的作用研究
Lara Petersen,Rimma Bachmann,Sven Meinerz et al.
Lara Petersen et al.
The epsin-related adaptor proteins Ent3p and Ent5p participate in budding of clathrin coated vesicles in transport between trans-Golgi network and endosomes in yeast. Transport of the arginine permease Can1p was analyzed, which recycles bet...
Real-time monitoring of cell surface protein arrival with split luciferases [0.03%]
分裂型萤光素酶用于检测细胞表面蛋白的动态表达量
Alexandra A M Fischer,Larissa Schatz,Julia Baaske et al.
Alexandra A M Fischer et al.
Each cell in a multicellular organism permanently adjusts the concentration of its cell surface proteins. In particular, epithelial cells tightly control the number of carriers, transporters and cell adhesion proteins at their plasma membra...
Endocytic pathways of pathogenic protein aggregates in neurodegenerative diseases [0.03%]
神经退行性疾病中病原蛋白聚集体的内吞途径
Pravin Hivare,Kratika Mujmer,Gitanjali Swarup et al.
Pravin Hivare et al.
Endocytosis is the fundamental uptake process through which cells internalize extracellular materials and species. Neurodegenerative diseases (NDs) are characterized by a progressive accumulation of intrinsically disordered protein species,...
Cholangiocytes express an isoform of soluble adenylyl cyclase that is N-linked glycosylated and secreted in extracellular vesicles [0.03%]
胆管细胞表达一种可溶型腺苷酸环化酶异构体，该异构体经N连接型糖基化并在胞外囊泡中分泌
Simei Go,Hang Lam Li,Jung-Chin Chang et al.
Simei Go et al.
Soluble adenylyl cyclase (sAC)-derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels remains underexplored. We consistently observed a 85 kD (sAC85 ) or 75 kD (sAC75 ) sAC protein ...
The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases [0.03%]
细胞外囊泡在铁稳态和铁死亡中的作用：聚焦肌肉骨骼疾病
Zhiwei Liao,Bide Tong,Zixuan Ou et al.
Zhiwei Liao et al.
Iron homeostasis is crucial for maintaining proper cellular function, and its disruption is considered one of the pathogenic mechanisms underlying musculoskeletal diseases. Under conditions of oxidative stress, the accumulation of cellular ...