Role of trafficking protein particle complex 2 in medaka development [0.03%]
脊索动物拟齿鱼中 Trafficking Protein Particle Complex 2 的作用
Francesca Zappa,Daniela Intartaglia,Andrea M Guarino et al.
Francesca Zappa et al.
The skeletal dysplasia spondyloepiphyseal dysplasia tarda (SEDT) is caused by mutations in the TRAPPC2 gene, which encodes Sedlin, a component of the trafficking protein particle (TRAPP) complex that we have shown previously to be required ...
Sequence elements within the PEXEL motif and its downstream region modulate PTEX-dependent protein export in Plasmodium falciparum [0.03%]
恶性疟原虫血症子中PEXEL基序及其下游区域内的序列元件调控蛋白输出
Mikha Gabriela,Claudia B G Barnes,Dickson Leong et al.
Mikha Gabriela et al.
The parasite Plasmodium falciparum causes the most severe form of malaria and to invade and replicate in red blood cells (RBCs), it exports hundreds of proteins across the encasing parasitophorous vacuole membrane (PVM) into this host cell....
Peroxisome population control by phosphoinositide signaling at the endoplasmic reticulum-plasma membrane interface [0.03%]
内质网-质膜界面磷脂信号控制过氧化物酶体数量
Barbara Knoblach,Richard A Rachubinski
Barbara Knoblach
Phosphoinositides are lipid signaling molecules acting at the interface of membranes and the cytosol to regulate membrane trafficking, lipid transport and responses to extracellular stimuli. Peroxisomes are multicopy organelles that are hig...
Amy K Clippinger,Teresa V Naismith,Wonjin Yoo et al.
Amy K Clippinger et al.
ESCRTs (Endosomal Sorting Complex Required for Transports) are a modular set of protein complexes with membrane remodeling activities that include the formation and release of intraluminal vesicles (ILVs) to generate multivesicular endosome...
A new Caenorhabditis elegans model to study copper toxicity in Wilson disease [0.03%]
用于研究威尔森病铜毒性的新芽丝虫病模式动物模型
Federico Catalano,Thomas J O&#x;Brien,Aleksandra A Mekhova et al.
Federico Catalano et al.
Wilson disease (WD) is caused by mutations in the ATP7B gene that encodes a copper (Cu) transporting ATPase whose trafficking from the Golgi to endo-lysosomal compartments drives sequestration of excess Cu and its further excretion from hep...
Copper-independent lysosomal localisation of the Wilson disease protein ATP7B [0.03%]
不依赖铜的威尔森病蛋白ATP7B的溶酶体定位
Saptarshi Maji,Marinella Pirozzi,Ruturaj et al.
Saptarshi Maji et al.
In hepatocytes, the Wilson disease protein ATP7B resides on the trans-Golgi network (TGN) and traffics to peripheral lysosomes to export excess intracellular copper through lysosomal exocytosis. We found that in basal copper or even upon co...
Fast backward steps and detachment of single kinesin molecules measured under a wide range of loads [0.03%]
快速回退和单个肌动蛋白分子在广泛负载下的脱落测量
Yuichi Kondo,Kazuo Sasaki,Hideo Higuchi
Yuichi Kondo
To understand force generation under a wide range of loads, the stepping of single kinesin molecules was measured at loads from -20 to 42 pN by optical tweezers with high temporal resolution. The optical trap has been improved to halve posi...
Interferon induction by STING requires its translocation to the late endosomes [0.03%]
STING通过向晚期内体转位诱导干扰素的产生
Chenyao Wang,Nikhil Sharma,Patricia M Kessler et al.
Chenyao Wang et al.
To combat microbial infections, mammalian cells use a variety of innate immune response pathways to induce synthesis of anti-microbial proteins. The cGAS/STING pathway recognizes cytoplasmic viral or cellular DNA to elicit signals that lead...
Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta [0.03%]
共伴侣BAG3通过与微管相关蛋白1轻链多肽3β的相互作用进入自噬途径
Hagen Körschgen,Marius Baeken,Daniel Schmitt et al.
Hagen Körschgen et al.
The co-chaperone BAG3 is a hub for a variety of cellular pathways via its multiple domains and its interaction with chaperones of the HSP70 family or small HSPs. During aging and under cellular stress conditions in particular, BAG3, togethe...
Diamond controls epithelial polarity through the dynactin-dynein complex [0.03%]
钻石通过动力蛋白复合物控制上皮细胞极性
Hang Zhao,Lin Shi,Zhengran Li et al.
Hang Zhao et al.
Epithelial polarity is critical for proper functions of epithelial tissues, tumorigenesis, and metastasis. The evolutionarily conserved transmembrane protein Crumbs (Crb) is a key regulator of epithelial polarity. Both Crb protein and its t...