Inhibition of Autophagy Alters Intracellular Transport of APP Resulting in Increased APP Processing [0.03%]
自噬作用抑制改变APP的胞内运输导致APP处理增加
Johanna Mayer,Dominik Boeck,Michelle Werner et al.
Johanna Mayer et al.
Alzheimer's disease (AD) pathology is characterized by amyloid beta (Aβ) plaques and dysfunctional autophagy. Aβ is generated by sequential proteolytic cleavage of amyloid precursor protein (APP), and the site of intracellular APP process...
ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism [0.03%]
ATG7与代谢蛋白相互作用并调节能量代谢
Kevin Ostacolo,Adrián López García de Lomana,Clémence Larat et al.
Kevin Ostacolo et al.
Macroautophagy/autophagy is an essential catabolic process that targets a wide variety of cellular components including proteins, organelles, and pathogens. ATG7, a protein involved in the autophagy process, plays a crucial role in maintain...
Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site [0.03%]
时空图谱揭示了致病性瑞典APP突变的主要作用部位是高尔基体：家族性APP突变主要改变了APP的作用部位
Jingqi Wang,Paul A Gleeson,Lou Fourriere
Jingqi Wang
Alzheimer's disease is associated with increased levels of amyloid beta (Aβ) generated by sequential intracellular cleavage of amyloid precursor protein (APP) by membrane-bound secretases. However, the spatial and temporal APP cleavage eve...
Exploring Retrograde Trafficking: Mechanisms and Consequences in Cancer and Disease [0.03%]
探索逆向运输：癌症和疾病中的机制与后果
Rachel Bingham,Helen McCarthy,Niamh Buckley
Rachel Bingham
Retrograde trafficking (RT) orchestrates the intracellular movement of cargo from the plasma membrane, endosomes, Golgi or endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) in an inward/ER-directed manner. RT works as the op...
Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation [0.03%]
糖皮质激素挽救了R451C神经蛋白3的细胞表面转运并促进了突触形成
Tamara Diamanti,Laura Trobiani,Lorenza Mautone et al.
Tamara Diamanti et al.
Neuroligins are synaptic cell adhesion proteins with a role in synaptic function, implicated in neurodevelopmental disorders. The autism spectrum disorder-associated substitution Arg451Cys (R451C) in NLGN3 promotes a partial misfolding of t...
The emerging functions of intraflagellar transport 52 in ciliary transport and ciliopathies [0.03%]
介观细胞内运输52在纤毛运输和纤毛病中新兴功能
Prajna Udupa,Debasish Kumar Ghosh
Prajna Udupa
Ciliary transport in eukaryotic cells is an intricate and conserved process involving the coordinated assembly and functioning of a multiprotein intraflagellar transport (IFT) complex. Among the various IFT proteins, intraflagellar transpor...
Mechanisms regulating the intracellular trafficking and release of CLN5 and CTSD [0.03%]
调节CLN5和CTSD的胞内运输及释放的机制
Robert J Huber,William D Kim,Morgan L D M Wilson-Smillie
Robert J Huber
Ceroid lipofuscinosis neuronal 5 (CLN5) and cathepsin D (CTSD) are soluble lysosomal enzymes that also localize extracellularly. In humans, homozygous mutations in CLN5 and CTSD cause CLN5 disease and CLN10 disease, respectively, which are ...
Endoglin mutants retained in the endoplasmic reticulum exacerbate loss of function in hereditary hemorrhagic telangiectasia type 1 (HHT1) by exerting dominant negative effects on the wild type allele [0.03%]
内质网滞留的内globulin突变体通过对其野生型等位基因的显性负效应加剧第一类遗传性出血性毛细血管扩张症（HHT1）的功能丧失
Nesrin Gariballa,Sally Badawi,Bassam R Ali
Nesrin Gariballa
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder affecting 1 in 5000-8000 individuals. Hereditary hemorrhagic telangiectasia type 1 (HHT1) is the most common HHT and manifests as diverse vascular malformations r...
Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells [0.03%]
UGGT1基因敲除哺乳动物细胞对罕见疾病相关异常糖蛋白分泌的救援作用
Gabor Tax,Kevin P Guay,Ludovica Pantalone et al.
Gabor Tax et al.
Endoplasmic reticulum (ER) retention of misfolded glycoproteins is mediated by the ER-localized eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognizes a misfolded glycoprote...
A vesicular Warburg effect: Aerobic glycolysis occurs on axonal vesicles for local NAD+ recycling and transport [0.03%]
一种囊泡瓦堡效应：有氧糖酵解发生在轴突囊泡上以进行局部NAD+循环利用和运输
Maximilian Mc Cluskey,Hervé Dubouchaud,Anne-Sophie Nicot et al.
Maximilian Mc Cluskey et al.
In neurons, fast axonal transport (FAT) of vesicles occurs over long distances and requires constant and local energy supply for molecular motors in the form of adenosine triphosphate (ATP). FAT is independent of mitochondrial metabolism. I...