Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer Cells [0.03%]
营养限制下癌细胞中Rab7a的转录后调控及其在溶酶体定位和耐药性中的作用
Aliye Ezgi Güleç Taşkıran,Hepşen H Hüsnügil,Zahra E Soltani et al.
Aliye Ezgi Güleç Taşkıran et al.
Limited nutrient availability in the tumor microenvironment can cause the rewiring of signaling and metabolic networks to confer cancer cells with survival advantages. We show here that the limitation of glucose, glutamine and serum from th...
Dissociation of Drosophila Evi-Wg Complex Occurs Post Apical Internalization in the Maturing Acidic Endosomes [0.03%]
果蝇Evi-Wg复合物在成熟酸性内体中顶点向内的转运后解离
Satyam Sharma,Varun Chaudhary
Satyam Sharma
Signaling pathways activated by secreted Wnt ligands play an essential role in tissue development and the progression of diseases, like cancer. Secretion of the lipid-modified Wnt proteins is tightly regulated by a repertoire of intracellul...
Mechanistic Insights Into an Ancient Adenovirus Precursor Protein VII Show Multiple Nuclear Import Receptor Pathways [0.03%]
古老的腺病毒前体蛋白VII机制见解展示了多个核输入受体途径
Sepehr Nematollahzadeh,Ajani Athukorala,Camilla M Donnelly et al.
Sepehr Nematollahzadeh et al.
Adenoviral pVII proteins are multifunctional, highly basic, histone-like proteins that can bind to and transport the viral genome into the host cell nucleus. Despite the identification of several nuclear localization signals (NLSs) in the p...
Intercellular Mitochondrial Transfer: The Novel Therapeutic Mechanism for Diseases [0.03%]
细胞间线粒体转移：疾病的新型治疗机制
Huimei Liu,Hui Mao,Xueqian Ouyang et al.
Huimei Liu et al.
Mitochondria, the dynamic organelles responsible for energy production and cellular metabolism, have the metabolic function of extracting energy from nutrients and synthesizing crucial metabolites. Nevertheless, recent research unveils that...
Intracellular Trafficking Defects in Congenital Intestinal and Hepatic Diseases [0.03%]
先天性肠肝病的细胞内运输缺陷
Luca Szabó,Adam R Pollio,Georg Friedrich Vogel
Luca Szabó
Enterocytes and liver cells fulfill important metabolic and barrier functions and are responsible for crucial vectorial secretive and absorptive processes. To date, genetic diseases affecting metabolic enzymes or transmembrane transporters ...
SNX32 Regulates Sorting and Trafficking of Activated EGFR to the Lysosomal Degradation Pathway [0.03%]
SNX32调节活化型EGFR向溶酶体降解通路的分类和转运
Dou Wang,Xia Zhao,Panpan Wang et al.
Dou Wang et al.
SNX32 is a member of the evolutionarily conserved Phox (PX) homology domain- and Bin/Amphiphysin/Rvs (BAR) domain- containing sorting nexin (SNX-BAR) family of proteins, which play important roles in sorting and membrane trafficking of endo...
Rab GTPases, Active Members in Antigen-Presenting Cells, and T Lymphocytes [0.03%]
参与呈递抗原的细胞和T淋巴细胞中的Rab GTP酶家族成员
Nidia Carolina Moreno-Corona,Mercedes Piedad de León-Bautista,Moises León-Juárez et al.
Nidia Carolina Moreno-Corona et al.
Processes such as cell migration, phagocytosis, endocytosis, and exocytosis refer to the intense exchange of information between the internal and external environment in the cells, known as vesicular trafficking. In eukaryotic cells, these ...
Apolipoprotein E2 Expression Alters Endosomal Pathways in a Mouse Model With Increased Brain Exosome Levels During Aging [0.03%]
载脂蛋白E2表达改变小鼠模型的内体途径，在衰老过程中脑外泌体水平升高
Katherine Y Peng,Braison Liemisa,Jonathan Pasato et al.
Katherine Y Peng et al.
The polymorphic APOE gene is the greatest genetic determinant of sporadic Alzheimer's disease risk: the APOE4 allele increases risk, while the APOE2 allele is neuroprotective compared with the risk-neutral APOE3 allele. The neuronal endosom...
EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells [0.03%]
EFA6A通过调节PC12细胞中NGF依赖的TrkA从早期囊泡回流及神经突起的生长来调控Arf6
Masahiro Fukaya,Kanta Ibuchi,Takeyuki Sugawara et al.
Masahiro Fukaya et al.
Endosomal trafficking of TrkA is a critical process for nerve growth factor (NGF)-dependent neuronal cell survival and differentiation. The small GTPase ADP-ribosylation factor 6 (Arf6) is implicated in NGF-dependent processes in PC12 cells...
Extracellular Vesicles: Translational Agenda Questions for Three Protozoan Parasites [0.03%]
细胞外囊泡：三种原生动物寄生虫的转化议程问题
Kwesi Z Tandoh,Ana Victoria Ibarra-Meneses,David Langlais et al.
Kwesi Z Tandoh et al.
The protozoan parasites Plasmodium falciparum, Leishmania spp. and Trypanosoma cruzi continue to exert a significant toll on the disease landscape of the human population in sub-Saharan Africa and Latin America. Control measures have helped...