Regulation of RNA granules by FMRP and implications for neurological diseases [0.03%]
FMRP调节RNA颗粒及其对神经疾病的影响
Austin Lai,Arielle N Valdez-Sinon,Gary J Bassell
Austin Lai
RNA granule formation, which can be regulated by RNA-binding proteins (RBPs) such as fragile X mental retardation protein (FMRP), acts as a mechanism to control both the repression and subcellular localization of translation. Dysregulated a...
Mechanisms and consequences of subcellular RNA localization across diverse cell types [0.03%]
多种细胞类型中亚细胞RNA定位的机制及其后果
Krysta L Engel,Ankita Arora,Raeann Goering et al.
Krysta L Engel et al.
Essentially all cells contain a variety of spatially restricted regions that are important for carrying out specialized functions. Often, these regions contain specialized transcriptomes that facilitate these functions by providing transcri...
ESCRT-dependent protein sorting is required for the viability of yeast clathrin-mediated endocytosis mutants [0.03%]
酵母依赖于CLATHRIN的内吞体突变体需要依靠ESCRT介导的蛋白分类来维持其活性
Kyle Hoban,Samantha Y Lux,Joanna Poprawski et al.
Kyle Hoban et al.
Endocytosis regulates many processes, including signaling pathways, nutrient uptake, and protein turnover. During clathrin-mediated endocytosis (CME), adaptors bind to cytoplasmic regions of transmembrane cargo proteins, and many endocytic ...
Size-dependent secretory protein reflux into the cytosol in association with acute endoplasmic reticulum stress [0.03%]
与急性内质网应激相关的大小依赖性分泌蛋白向细胞质的回流
Patrick Lajoie,Erik L Snapp
Patrick Lajoie
Once secretory proteins have been targeted to the endoplasmic reticulum (ER) lumen, the proteins typically remain partitioned from the cytosol. If the secretory proteins misfold, they can be unfolded and retrotranslocated into the cytosol f...
Super-beacons: Open-source probes with spontaneous tuneable blinking compatible with live-cell super-resolution microscopy [0.03%]
超级荧光蛋白：与在体超分辨率显微镜兼容的可调自发闪烁的开源探针
Pedro M Pereira,Nils Gustafsson,Mark Marsh et al.
Pedro M Pereira et al.
Localization-based super-resolution microscopy relies on the detection of individual molecules cycling between fluorescent and non-fluorescent states. These transitions are commonly regulated by high-intensity illumination, imposing constra...
High-content imaging and structure-based predictions reveal functional differences between Niemann-Pick C1 variants [0.03%]
高内涵成像和基于结构的预测揭示Niemann-Pick C1变异体之间的功能差异
Lauri Vanharanta,Johan Peränen,Simon G Pfisterer et al.
Lauri Vanharanta et al.
The human Niemann-Pick C1 (NPC1) gene encoding a 1278 amino acid protein is very heterogeneous. While some variants represent benign polymorphisms, NPC disease carriers and patients may possess rare variants, whose functional importance rem...
Staying in touch with the endocytic network: The importance of contacts for cholesterol transport [0.03%]
不忘末照：胆固醇运输中的接触重要性
Andrea Martello,Fran M Platt,Emily R Eden
Andrea Martello
Cholesterol homeostasis is critical for cell function and human health. Cholesterol is heterogeneously distributed among cellular membranes, with the redistribution of endocytosed dietary cholesterol playing a pivotal role in the regulation...
Low Rho activity in hepatocytes prevents apical from basolateral cargo separation during trans-Golgi network to surface transport [0.03%]
低RHO活性防止肝细胞中肠上皮细胞顶侧从基底外侧货物分离在反面高尔基网络到表面运输期间
Francisco Lázaro-Diéguez,Anne Müsch
Francisco Lázaro-Diéguez
Hepatocytes, the main epithelial cells of the liver, organize their polarized membrane domains differently from ductal epithelia. They also differ in their biosynthetic delivery of single-membrane-spanning and glycophosphatidylinositol-anch...
Components of the Gs signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β2 -adrenergic receptor activation [0.03%]
β2-肾上腺素受体活化后Gs信号转导通路中的各组分在移动性和细胞膜定位上的变化不同
Alexey Bondar,Wonjo Jang,Ekaterina Sviridova et al.
Alexey Bondar et al.
The G protein signaling cascade is a key player in cell signaling. Cascade activation leads to a redistribution of its members in various cellular compartments. These changes are likely related to the "second wave" of signaling from endosom...
Ultrastructural insights into pathogen clearance by autophagy [0.03%]
由自噬介导的病原体清除的 ultrastructure 理解
Chieko Kishi-Itakura,Nicholas T Ktistakis,Folma Buss
Chieko Kishi-Itakura
Autophagy defends cells against proliferation of bacteria such as Salmonella in the cytosol. After escape from a damaged Salmonella-containing vacuole (SCV) exposing luminal glycans that bind to Galectin-8, the host cell ubiquitination mach...