CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators [0.03%]
CrebA通过直接转录调控分泌机制、一组分泌货物及其他关键调节因子来增强分泌能力
Dorothy M Johnson,Michael B Wells,Rebecca Fox et al.
Dorothy M Johnson et al.
Specialization of many cells, including the acinar cells of the salivary glands and pancreas, milk-producing cells of mammary glands, mucus-secreting goblet cells, antibody-producing plasma cells, and cells that generate the dense extracell...
A functionally neutral single chain antibody to measure beta-1 integrin uptake and recycling [0.03%]
一种功能中性的单链抗体可测定β-1整合素的摄取和循环回收作用
Ashley M Lakoduk,Zuzana Kadlecova,Sandra L Schmid
Ashley M Lakoduk
Integrin-mediated cell adhesion and signaling are critical for many physiological processes. The dynamic turnover of integrins and their associated adhesion complexes through endocytic and recycling pathways has emerged as an important mech...
Heterogeneity in the endocytic capacity of individual macrophage in a population determines its subsequent phagocytosis, infectivity and subcellular trafficking [0.03%]
群体中单个巨噬细胞的内吞能力异质性决定了其后续吞噬作用、感染性和亚细胞运输
Kuldeep Sachdeva,Manisha Goel,Varadharajan Sundaramurthy
Kuldeep Sachdeva
Phagocytosis is a complex cellular uptake process involving multiple distinct steps of cargo recognition, uptake, phagosome maturation and eventual phagolysosome resolution. Emerging literature shows that heterogeneity of phagocytosis at mu...
Kathryn Howell (1939-2020) "The Secretory Pathway was Imprinted in her Heart" [0.03%]
凯瑟琳•豪厄尔(1939-2020)：“分泌途径深深烙印在她心中”
John Bergeron,J David Castle
John Bergeron
On April 10, 2020, a treasured cell biologist and ardent champion of the Golgi complex passed away. This has caused deep sadness, and we seek to commemorate her remarkable scientific contributions, her warm and generous personality, and her...
The hypothetical role of phosphatidic acid in subverting ER membranes during SARS-CoV infection [0.03%]
磷脂酸在SARS-CoV感染期间颠覆内质网膜的假想作用
María Moriel-Carretero
María Moriel-Carretero
Positive sense (+) RNA viruses exploit membranes from a variety of cellular organelles to support the amplification of their genomes. This association concurs with the formation of vesicles whose main morphological feature is that of being ...
Fernando M Valbuena,Ivy Fitzgerald,Rita L Strack et al.
Fernando M Valbuena et al.
The green fluorescent protein (GFP) from Aequorea victoria has been engineered extensively in the past to generate variants suitable for protein tagging. Early efforts produced the enhanced variant EGFP and its monomeric derivative mEGFP, w...
Phosphatidylinositol 3,5-bisphosphate regulates Ca2+ transport during yeast vacuolar fusion through the Ca2+ ATPase Pmc1 [0.03%]
磷脂酰肌醇3,5-二磷酸通过Ca2+ATP酶Pmc1调节酵母囊泡融合过程中的Ca2+转运
Gregory E Miner,Katherine D Sullivan,Chi Zhang et al.
Gregory E Miner et al.
The transport of Ca2+ across membranes precedes the fusion and fission of various lipid bilayers. Yeast vacuoles under hyperosmotic stress become fragmented through fission events that requires the release of Ca2+ stores through the TRP cha...
Long-distance early endosome motility in Aspergillus fumigatus promotes normal hyphal growth behaviors in controlled microenvironments but is dispensable for virulence [0.03%]
长距离早期内体运动通过促进受控微环境中的正常菌丝生长行为来促进烟曲霉的生长，但对毒力并非必不可少
Baronger Dowell Bieger,Audra Mae Rogers,Steven Bates et al.
Baronger Dowell Bieger et al.
In filamentous fungi, early endosomes are continuously trafficked to, and from, the growing hyphal tip by microtubule-based motor proteins, serving as platforms for the long-distance transport of diverse cargos including mRNA, signaling mol...
The endosomal sorting complex required for transport complex negatively regulates Erg6 degradation under specific glucose restriction conditions [0.03%]
特定的葡萄糖限制条件下内吞体分选复合物对Erg6降解起负调控作用
Ao Zhang,Ying Meng,Qunli Li et al.
Ao Zhang et al.
Lipid droplets (LDs) are cytosolic fat storage organelles that play roles in lipid metabolism, trafficking and signaling. Breakdown of LDs in Saccharomyces cerevisiae is mainly achieved by lipolysis and lipophagy. In this study, we found th...
Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility [0.03%]
F684I突变体中的BicD螺旋桨节律转变可导致动力蛋白的非受体依赖性激活
Heying Cui,M Yusuf Ali,Puja Goyal et al.
Heying Cui et al.
The dynein adaptor Drosophila Bicaudal D (BicD) is auto-inhibited and activates dynein motility only after cargo is bound, but the underlying mechanism is elusive. In contrast, we show that the full-length BicD/F684I mutant activates dynein...