TNF-α-Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells [0.03%]
肿瘤坏死因子-α驱动的表皮生长因子受体极性运输的变化促进磷脂酰肌醇3-激酶/蛋白激酶B信号从MDCK上皮细胞的顶侧表面传递
Syntyche Ngalula,Cathleen R Carlin
Syntyche Ngalula
This manuscript describes a novel unconventional secretory pathway that facilitates EGF receptor (EGFR) signaling from apical membranes in polarized epithelial cells responding to immune cell mediators. Epithelial tissues provide a physical...
Identification of Rab GTPase-Activating Proteins Required for Tubular Endosome Formation [0.03%]
参与管状内体形成所必需的Rab GTP酶激活蛋白的鉴定
Shumpei Nakashima,Mitsunori Fukuda
Shumpei Nakashima
In certain kinds of cells, clathrin-independently endocytosed cargo proteins are recycled back to the plasma membrane via specialized tubular-shaped endosomes, so-called tubular endosomes. Several regulators, including Rab small GTPases, ha...
Prerna Sharma,Pooja Hoovina Venkatesh,Shalini Samal et al.
Prerna Sharma et al.
Arf-like GTPases (Arls) regulate membrane trafficking and cytoskeletal organization. Genetic studies predicted a role for Arl15 in type-2 diabetes, insulin resistance, adiposity, and rheumatoid arthritis. Cell biological studies implicated ...
Re-Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation [0.03%]
基于数学模拟的铁传递蛋白 intracellular 传输路径的再探讨
Franco Nieto,Luis S Mayorga
Franco Nieto
Modeling and simulation are transforming all fields of biology. Tools like AlphaFold have revolutionized structural biology, while molecular dynamics simulations provide invaluable insights into the behavior of macromolecules in solution or...
Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation [0.03%]
急性GARP耗竭扰乱囊泡运输，导致分选、分泌和O-连接糖基化出现严重缺陷
Amrita Khakurel,Irina Pokrovskaya,Walter S Aragon-Ramirez et al.
Amrita Khakurel et al.
The GARP complex is an evolutionarily conserved protein complex proposed to tether endosome-derived vesicles at the trans-Golgi network. While complete depletion of the GARP leads to severe trafficking and glycosylation defects, the primary...
Computational Modeling Reveals a Catch-and-Guide Interaction Between Kinesin-1 and Tubulin C-Terminal Tails [0.03%]
计算建模揭示了动力蛋白-1和微管蛋白C端尾部之间的捕捉与引导相互作用
Trini Nguyen,Steven P Gross,Christopher E Miles
Trini Nguyen
The delivery of intracellular cargoes by kinesins is modulated at scales ranging from the geometry of the microtubule networks down to interactions with individual tubulins and their code. The complexity of the tubulin code and the difficul...
Miharu Maeda,Masashi Arakawa,Kota Saito
Miharu Maeda
The endoplasmic reticulum (ER)-Golgi interface is essential for directing the transport of proteins synthesized in the ER to the Golgi apparatus via the ER-Golgi intermediate compartment, as well as for recycling proteins back to the ER. Th...
Adaptor-Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes [0.03%]
各种细胞过程中衔接子介导的Tank结合激酶1的转运
Swagatika Paul,Sahitya Ranjan Biswas,Julia P Milner et al.
Swagatika Paul et al.
The serine/threonine kinase, Tank Binding Kinase 1 (TBK1), drives distinct cellular processes like innate immune signaling, selective autophagy, and mitosis. It is suggested that the translocation and activation of TBK1 at different subcell...
Huyong Yan,Yixuan Deng
Huyong Yan
Phase separation is increasingly recognized as a paradigm to elucidate the self-assembly and organization of membrane-less bodies within the cell, which involves the segregation of a multi-component system into distinct phases with varying ...
Fluorescent Reporters, Imaging, and Artificial Intelligence Toolkits to Monitor and Quantify Autophagy, Heterophagy, and Lysosomal Trafficking Fluxes [0.03%]
用于监测和量化自噬、异噬和溶酶体转运通量的荧光报告工具包、成像及人工智能技术
Mikhail Rudinskiy,Diego Morone,Maurizio Molinari
Mikhail Rudinskiy
Lysosomal compartments control the clearance of cell-own material (autophagy) or of material that cells endocytose from the external environment (heterophagy) to warrant supply of nutrients, to eliminate macromolecules or parts of organelle...