Phosphorylation of Rab GTPases in the regulation of membrane trafficking [0.03%]
Rab GTP酶的磷酸化在膜转运调控中的作用
Dieter Waschbüsch,Amir R Khan
Dieter Waschbüsch
Rab GTPases are master regulators of membrane trafficking in eukaryotic cells. Phosphorylation of Rab GTPases was characterized in the 1990s and there have been intermittent reports of its relevance to Rab functions. Phosphorylation as a re...
A novel labeling strategy reveals that myosin Va and myosin Vb bind the same dendritically polarized vesicle population [0.03%]
一种新的标记策略揭示了肌球蛋白Va和肌球蛋白Vb结合相同的树突极化囊泡群
Madeline Frank,Clara G Citarella,Geraldine B Quinones et al.
Madeline Frank et al.
Neurons are specialized cells with a polarized geometry and several distinct subdomains that require specific complements of proteins. Delivery of transmembrane proteins requires vesicle transport, which is mediated by molecular motor prote...
Yvonne Lange,Theodore L Steck
Yvonne Lange
This review considers the following hypotheses, some well-supported and some speculative. Almost all of the sterol molecules in plasma membranes are associated with bilayer phospholipids in complexes of varied strength and stoichiometry. Th...
Miguel A Peñalva,Esteban Moscoso-Romero,Miguel Hernández-González
Miguel A Peñalva
Secretion of the glycosylphosphatidylinositol-anchored protein (GPI-AP) EglC was investigated in the filamentous fungus Aspergillus nidulans, exploiting a sucrose-inducible promoter to conditionally express the protein in cells blocked at d...
Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis [0.03%]
tomosyn对胰岛素刺激的GLUT4出胞作用发挥抑制作用的遗传证据
Shifeng Wang,Yinghui Liu,Lauren Crisman et al.
Shifeng Wang et al.
Exocytosis is a vesicle fusion process driven by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). A classic exocytic pathway is insulin-stimulated translocation of the glucose transporter type 4 (GLUT4) from ...
Correction to: Intestinal M cells: Tireless samplers of enteric microbiota [0.03%]
校正：肠M细胞：不知疲倦的肠道微生物采样者
Takashi Kanaya,Ifor R Williams,Hiroshi Ohno
Takashi Kanaya
Published Erratum
Traffic (Copenhagen, Denmark). 2020 Sep;21(9):617. DOI:10.1111/tra.12757 2020
Dissecting the roles of Cse1 and Nup2 in classical NLS-cargo release in vivo [0.03%]
Cse1和Nup2在经典NLS-货物释放中的作用的解析研究
Allison Lange,Milo B Fasken,Murray Stewart et al.
Allison Lange et al.
The importin α/β transport machinery mediates the nuclear import of cargo proteins that bear a classical nuclear localization sequence (cNLS). These cargo proteins are linked to the major nuclear protein import factor, importin-β, by the...
Nica Borgese
Nica Borgese
The tryptophan rich basic protein/calcium signal-modulating cyclophilin ligand (WRB/CAML) and Get1p/Get2p complexes, in vertebrates and yeast, respectively, mediate the final step of tail-anchored protein insertion into the endoplasmic reti...
Hypersensitivity of Vps33B mutant flies to non-pathogenic infections is dictated by aberrant activation of p38b MAP kinase [0.03%]
Vps33B突变体果蝇对非致病性感染的高敏感性由p38bMAP激酶异常活化介导
Jian Zhang,Charles Tracy,Chandrashekhar Pasare et al.
Jian Zhang et al.
Loss of the arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome-linked Vps33B protein results in exaggerated inflammatory responses upon activation of receptors of the innate immune system in both vertebrates and flies. However, lit...
An internally eGFP-tagged α-adaptin is a fully functional and improved fiduciary marker for clathrin-coated pit dynamics [0.03%]
内部标记eGFP的α-适配素是网格蛋白包被小窝动态变化的理想示踪标记蛋白质
Rosa E Mino,Zhiming Chen,Marcel Mettlen et al.
Rosa E Mino et al.
Clathrin mediated endocytosis (CME) has been extensively studied in living cells by quantitative total internal reflection fluorescence microscopy (TIRFM). Fluorescent protein fusions to subunits of the major coat proteins, clathrin light c...