Federico Colombo,Giacomo Casella,Paola Podini et al.
Federico Colombo et al.
Extracellular vesicles (EVs), a broad term for the lipid microparticles known as microvesicles and exosomes, are discharged by cells into their surrounding space. Microvesicles are discharged upon outward plasma membrane budding, while exos...
Positioning of endoplasmic reticulum exit sites around the Golgi depends on BicaudalD2 and Rab6 activity [0.03%]
BicaudalD2和Rab6活性决定内质网出位点在高尔基体周围的定位
Olga Shomron,Koret Hirschberg,Anton Burakov et al.
Olga Shomron et al.
The endoplasmic reticulum (ER) is involved in biogenesis, modification and transport of secreted and membrane proteins. The ER membranes are spread throughout the cell cytoplasm as well as the export domains known as ER exit sites (ERES). A...
Knockout of RSN1, TVP18 or CSC1-2 causes perturbation of Golgi cisternae in Pichia pastoris [0.03%]
RSN1、TVP18或CSC1-2敲除导致毕赤酵母高尔基体小囊结构异常
Rochelle Aw,Charlot De Wachter,Bram Laukens et al.
Rochelle Aw et al.
The structural organization of the Golgi stacks in mammalian cells is intrinsically linked to function, including glycosylation, but the role of morphology is less clear in lower eukaryotes. Here we investigated the link between the structu...
Inhibition of clathrin-mediated endocytosis by knockdown of AP-2 leads to alterations in the plasma membrane proteome [0.03%]
AP-2敲低抑制网格蛋白介导的内吞作用并导致细胞膜蛋白质组变化
David Tobys,Lisa Maria Kowalski,Eva Cziudaj et al.
David Tobys et al.
In eukaryotic cells, clathrin-mediated endocytosis (CME) is a central pathway for the internalization of proteins from the cell surface, thereby contributing to the maintenance of the plasma membrane protein composition. A key component for...
Genetically encoded multimode reporter of adaptor complex 3 traffic in budding yeast [0.03%]
编码多种报告基因的遗传载体 comprehensively reports on adaptor complex 3交通在出芽酵母中
Rachael L Plemel,Greg Odorizzi,Alexey J Merz
Rachael L Plemel
AP-3 (adaptor complex 3) mediates traffic from the late Golgi or early endosomes to late endosomal compartments. In mammals, mutations in AP-3 cause Hermansky-Pudlak syndrome type 2, cyclic neutropenias, and a form of epileptic encephalopat...
A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance [0.03%]
保守的谷氨酸残基通过抑制ALFY膜结合来促进蛋白聚集体清除
Erin F Reinhart,Nicole A Litt,Sarah Katzenell et al.
Erin F Reinhart et al.
Autophagy-linked FYVE protein (ALFY) is a large, multidomain protein involved in the degradation of protein aggregates by selective autophagy. The C-terminal FYVE domain of ALFY has been shown to bind phosphatidylinositol 3-phosphate (PI(3)...
A new direction for Traffic [0.03%]
交通新导向
Michael S Marks,Robert G Parton,Trina A Schroer et al.
Michael S Marks et al.
Intercellular movement of plant RNA viruses: Targeting replication complexes to the plasmodesma for both accuracy and efficiency [0.03%]
植物rna病毒的细胞间运动：为了准确和高效地将复制复合物靶向胞间连丝
Xiaoyun Wu,Xiaofei Cheng
Xiaoyun Wu
Replication and movement are two critical steps in plant virus infection. Recent advances in the understanding of the architecture and subcellular localization of virus-induced inclusions and the interactions between viral replication compl...
Local gene regulation in radial glia: Lessons from across the nervous system [0.03%]
放射状胶质细胞中的局部基因调控：来自神经系统其他部位的启示
Brooke R D&#x;Arcy,Debra L Silver
Brooke R D&#x;Arcy
Radial glial cells (RGCs) are progenitors of the cerebral cortex which produce both neurons and glia during development. Given their central role in development, RGC dysfunction can result in diverse neurodevelopmental disorders. RGCs have ...
The Ubp3/Bre5 deubiquitylation complex modulates COPII vesicle formation [0.03%]
Ubp3/Bre5去泛素化复合物调节COPII有被小泡的形成
Natalia Gomez-Navarro,Jérôme Boulanger,Elizabeth A Miller
Natalia Gomez-Navarro
The appropriate delivery of secretory proteins to the correct subcellular destination is an essential cellular process. In the endoplasmic reticulum (ER), secretory proteins are captured into COPII vesicles that generally exclude ER residen...