Discovery and biological evaluation of a small-molecule inhibitor of CRM1 that suppresses the growth of triple-negative breast cancer cells [0.03%]
一种新型小分子抑制剂CRM1的发现及其在三阴性乳腺癌细胞增殖抑制中的作用研究
Jiujiao Gao,Peng Chu,Caigang Liu et al.
Jiujiao Gao et al.
Dysregulation of the nuclear export machinery mediated by chromosomal maintenance 1 (CRM1, also known as exportin-1), is closely associated with various human disorders, such as breast cancer. Previously, we identified sulforaphene and its ...
Deep learning for automatic segmentation of the nuclear envelope in electron microscopy data, trained with volunteer segmentations [0.03%]
利用志愿者分割数据训练电子显微镜数据的核包膜自动分割模型
Helen Spiers,Harry Songhurst,Luke Nightingale et al.
Helen Spiers et al.
Advancements in volume electron microscopy mean it is now possible to generate thousands of serial images at nanometre resolution overnight, yet the gold standard approach for data analysis remains manual segmentation by an expert microscop...
CaV β controls the endocytic turnover of CaV 1.2 L-type calcium channel [0.03%]
CaVβ调控CaV1.2 L型钙通道的内吞周转率
Rachel Conrad,Daniel Kortzak,Gustavo A Guzman et al.
Rachel Conrad et al.
Membrane depolarization activates the multisubunit CaV 1.2 L-type calcium channel initiating various excitation coupling responses. Intracellular trafficking into and out of the plasma membrane regulates the channel's surface expression and...
Implicating extracellular vesicles in Plasmodium falciparum artemisinin resistance development [0.03%]
疟原虫艾姆斯汀素抗药性发展的细胞外囊泡作用机制研究
Kwesi Z Tandoh,Michael D Wilson,Neils B Quashie et al.
Kwesi Z Tandoh et al.
Plasmodium falciparum malaria remains a disease of significant public health impact today. With the risk of emerging artemisinin resistance stalling malaria control efforts, the need to deepen our understanding of the parasite's biology is ...
Transfer of mitochondria and endosomes between cells by gap junction internalization [0.03%]
缝隙连接内吞介导的线粒体和内噬体在细胞间的转移
Rachael P Norris
Rachael P Norris
Intercellular organelle transfer has been documented in several cell types and has been proposed to be important for cell-cell communication and cellular repair. However, the mechanisms by which organelle transfer occurs are uncertain. Rece...
Versatile allosteric properties in Pex5-like tetratricopeptide repeat proteins to induce diverse downstream function [0.03%]
具多样别构性质的过客蛋白Pex5样TPR蛋白及其诱导多种功能发生的机制研究
Jérôme Bürgi,Lakhan Ekal,Matthias Wilmanns
Jérôme Bürgi
Proteins composed of tetratricopeptide repeat (TPR) arrays belong to the α-solenoid tandem-repeat family that have unique properties in terms of their overall conformational flexibility and ability to bind to multiple protein ligands. The ...
Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis [0.03%]
Tau寡聚体通过P2Y12R介导的趋化作用重塑小胶质细胞肌动蛋白网络
Rashmi Das,Subashchandrabose Chinnathambi
Rashmi Das
Alzheimer's disease (AD) is associated with age-related neurodegeneration, synaptic deformation and chronic inflammation mediated by microglia and infiltrated macrophages in the brain. Tau oligomers can be released from damaged neurons via ...
Ekta Dembla,Ute Becherer
Ekta Dembla
Large dense core vesicle (LDCVs) biogenesis in neuroendocrine cells involves: (a) production of cargo peptides processed in the Golgi; (b) fission of cargo loaded LDCVs undergoing maturation steps; (c) movement of these LDCVs to the plasma ...
Formation of retromer transport carriers is disrupted by the Parkinson disease-linked Vps35 D620N variant [0.03%]
帕金森病相关基因Vps35 D620N突变体通过破坏retromer运输载体的形成诱导多巴胺神经元退行性病变
Yi Cui,Zhe Yang,Neftali Flores-Rodriguez et al.
Yi Cui et al.
Retromer core complex is an endosomal scaffold that plays a critical role in orchestrating protein trafficking within the endosomal system. Here we characterized the effect of the Parkinson's disease-linked Vps35 D620N in the endo-lysosomal...
The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues [0.03%]
免疫ophilin Zonda控制内分泌和外分泌组织的受调节胞吐作用
Rocío de la Riva-Carrasco,Sebastián Perez-Pandolfo,Sofía Suárez Freire et al.
Rocío de la Riva-Carrasco et al.
Exocytosis is a fundamental process in physiology, that ensures communication between cells, organs and even organisms. Hormones, neuropeptides and antibodies, among other cargoes are packed in exocytic vesicles that need to reach and fuse ...