Phosphatidic acid-PKA signaling regulates p38 and ERK1/2 functions in ligand-independent EGFR endocytosis [0.03%]
磷脂酸-PKA信号调控配体非依赖性EGFR内吞的p38和ERK1/2功能
Claudia Metz,Claudia Oyanadel,Juan Jung et al.
Claudia Metz et al.
Ligand-independent epidermal growth factor receptor (EGFR) endocytosis is inducible by a variety of stress conditions converging upon p38 kinase. A less known pathway involves phosphatidic acid (PA) signaling toward the activation of type 4...
Late endosomal/lysosomal accumulation of a neurotransmitter receptor in a cellular model of Smith-Lemli-Opitz syndrome [0.03%]
Smith-Lemli-Opitz 综合征细胞模型中的神经递质受体晚期内涵体/溶酶体积累增多现象
Ashwani Sharma,G Aditya Kumar,Amitabha Chattopadhyay
Ashwani Sharma
Smith-Lemli-Opitz syndrome (SLOS) is a congenital and developmental malformation syndrome associated with defective cholesterol biosynthesis. It is characterized by accumulation of 7-dehydrocholesterol (the immediate biosynthetic precursor ...
RNA, a new member in the glycan-club that gets exposed at the cell surface [0.03%]
糖类大家族的新成员——细胞表面暴露的RNA
Eric Chevet,Maria Antonietta De Matteis,Eeva-Liisa Eskelinen et al.
Eric Chevet et al.
In this article we discuss implications of the recent discovery of glycoRNAs found to be present at the cell surface of mammalian cells which was reported by Flynn et al. Cell 2021. ...
Sequence-based features that are determinant for tail-anchored membrane protein sorting in eukaryotes [0.03%]
决定真核生物尾部锚定膜蛋白分类的序列特征
Michelle Y Fry,Shyam M Saladi,Alexandre Cunha et al.
Michelle Y Fry et al.
The correct targeting and insertion of tail-anchored (TA) integral membrane proteins is critical for cellular homeostasis. TA proteins are defined by a hydrophobic transmembrane domain (TMD) at their C-terminus and are targeted to either th...
Amyloid β production along the neuronal secretory pathway: Dangerous liaisons in the Golgi? [0.03%]
神经分泌途径上的淀粉样β蛋白生成：在高尔基体中危险的关系吗？
Lou Fourriere,Paul A Gleeson
Lou Fourriere
β-amyloid peptides (Aβ) are generated in intracellular compartments of neurons and secreted to form cytotoxic fibrils and plaques. Dysfunctional membrane trafficking contributes to aberrant Aβ production and Alzheimer's disease. Endosome...
Legionella pneumophila LegC7 effector protein drives aberrant endoplasmic reticulum:endosome contacts in yeast [0.03%]
Legionella pneumophila效应蛋白LegC7驱动酵母内质网与囊泡的异常接触
Nathan K Glueck,Kevin M O&#x;Brien,Danielle C Seguin et al.
Nathan K Glueck et al.
Legionella pneumophila is a facultative intracellular bacterial pathogen, causing the severe form of pneumonia known as Legionnaires' disease. Legionella actively alters host organelle trafficking through the activities of "effector" protei...
Dynamic, variable oligomerization and the trafficking of variant surface glycoproteins of Trypanosoma brucei [0.03%]
特布雷丝原虫变异表面糖蛋白的动态变聚及转运过程
Khan Umaer,Francisco Aresta-Branco,Monica Chandra et al.
Khan Umaer et al.
African trypanosomes cause disease in humans and livestock, avoiding host immunity by changing the expression of variant surface glycoproteins (VSGs); the major glycosylphosphatidylinositol (GPI) anchored antigens coating the surface of the...
Zulin Wu,Haiqian Xu,Junze Liu et al.
Zulin Wu et al.
Mitochondria play important roles in energy generation and homeostasis maintenance in eukaryotic cells. The damaged or superfluous mitochondria can be nonselectively or selectively removed through the autophagy/lysosome pathway, which was r...
Proteoglycan synthesis in conserved oligomeric Golgi subunit deficient HEK293T cells is affected differently, depending on the lacking subunit [0.03%]
含不同缺乏组分的保守性寡聚高尔基体复合体缺陷HEK293T细胞的蛋白多糖合成受影响情况不同
Ravi Adusumalli,Hans-Christian Åsheim,Vladimir Lupashin et al.
Ravi Adusumalli et al.
The Conserved Oligomeric Golgi (COG) complex is an eight subunit protein complex associated with Golgi membranes. Genetic defects affecting individual COG subunits cause congenital disorders of glycosylation (CDGs), due to mislocalization o...
The role of lipids in exosome biology and intercellular communication: Function, analytics and applications [0.03%]
脂质在细胞外囊泡生物学及细胞间通讯中的作用：功能、分析和应用
Javier Donoso-Quezada,Sergio Ayala-Mar,José González-Valdez
Javier Donoso-Quezada
Exosomes are extracellular vesicles that in recent years have received special attention for their regulatory functions in numerous biological processes. Recent evidence suggests a correlation between the composition of exosomes in body flu...