Profound architectural and functional readjustments of the secretory pathway in decidualization of endometrial stromal cells [0.03%]
子宫内膜基质细胞蜕膜化过程中分泌通路出现深刻地结构和功能调整
Tiziana Anelli,Marco Dalla Torre,Elena Borini et al.
Tiziana Anelli et al.
Certain cell types must expand their exocytic pathway to guarantee efficiency and fidelity of protein secretion. A spectacular case is offered by decidualizing human endometrial stromal cells (EnSCs). In the midluteal phase of the menstrual...
Implication of the nuclear trafficking of rabies virus P3 protein in viral pathogenicity [0.03%]
狂犬病毒P3蛋白核转运在病毒致病性中的意义
Aaron M Brice,Ericka Watts,Bevan Hirst et al.
Aaron M Brice et al.
Although the majority of viruses of the family Mononegvirales replicate exclusively in the host cell cytoplasm, many of these viruses encode proteins that traffic between the nucleus and cytoplasm, which is believed to enable accessory func...
EAP45 association with budding HIV-1: Kinetics and domain requirements [0.03%]
EAP45与出芽HIV-1的关联：动力学和域需求
Bo Meng,Pedro P Vallejo Ramirez,Katharina M Scherer et al.
Bo Meng et al.
A number of viruses including HIV use the ESCRT system to bud from the infected cell. We have previously confirmed biochemically that ESCRT-II is involved in this process in HIV-1 and have defined the molecular domains that are important fo...
Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons [0.03%]
蛋白激酶D促进海马神经元的活动依赖性AMPA受体胞吞作用
Carlos O Oueslati Morales,Attila Ignácz,Norbert Bencsik et al.
Carlos O Oueslati Morales et al.
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type glutamate receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the brain. The continuous trafficking of AMPARs into and out of synapses is a core f...
Secretion of a low-molecular-weight species of endogenous GRP94 devoid of the KDEL motif during endoplasmic reticulum stress in Chinese hamster ovary cells [0.03%]
中国仓鼠卵巢细胞内质网应激期间分泌低分子量的内源性无KDEL基序的GRP94物种
Andrew Samy,Noriko Yamano-Adachi,Yuichi Koga et al.
Andrew Samy et al.
GRP94 (glucose-regulated protein 94) is a well-studied chaperone with a lysine, aspartic acid, glutamic acid and leucine (KDEL) motif at its C-terminal, which is responsible for GRP94 localization in the endoplasmic reticulum (ER). GRP94 is...
Sharanya Chatterjee,Ana Jeemin Choi,Gad Frankel
Sharanya Chatterjee
Endoplasmic reticulum (ER)-to-Golgi trafficking is an essential and highly conserved cellular process. The coat protein complex-II (COPII) arm of the trafficking machinery incorporates a wide array of cargo proteins into vesicles through di...
Theodore L Steck,S M Ali Tabei,Yvonne Lange
Theodore L Steck
Cells manage their cholesterol by negative feedback using a battery of sterol-responsive proteins. How these activities are coordinated so as to specify the abundance and distribution of the sterol is unclear. We present a simple mathematic...
Fur4-mediated uracil-scavenging to screen for surface protein regulators [0.03%]
介导的尿嘧啶清除以筛选表面蛋白调节因子
Katherine M Paine,Gabrielle B Ecclestone,Chris MacDonald
Katherine M Paine
Cell surface membrane proteins perform diverse and critical functions and are spatially and temporally regulated by membrane trafficking pathways. Although perturbations in these pathways underlie many pathologies, our understanding of thes...
Shikha T Ramesh,Kolaparamba V Navyasree,Sneha Sah et al.
Shikha T Ramesh et al.
Phosphorylation of the central adaptor protein complex, AP-2 is pivotal for clathrin-mediated endocytosis (CME). Here, we uncover the role of an uncharacterized kinase (BMP-2 inducible kinase-BMP2K) in AP-2 phosphorylation. We demonstrate t...
The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages [0.03%]
巨噬细胞中跨SNARE复合物VAMP4/Stx6/Stx7/Vti1b是调节高尔基体至晚期内小体MT1-MMP转运的关键调控因子
Zoe Elizabeth West,Savannah Margaret Aitcheson,Annalese Barbara Trudy Semmler et al.
Zoe Elizabeth West et al.
The activity of the matrix metalloproteinase (MMP) MT1-MMP is strictly regulated by expression and cellular location. In macrophages LPS activation leads to the up-regulation of MT1-MMP and this need to be at the cell surface for them to de...