Segregation of the membrane cargoes, BACE1 and amyloid precursor protein (APP) throughout the Golgi apparatus [0.03%]
整个高尔基体上对膜运载物、BACE1和淀粉样前体蛋白(APP)的分隔
Lou Fourriere,Ellie Hyun-Jung Cho,Paul A Gleeson
Lou Fourriere
The intracellular trafficking of β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) and APP regulates amyloid-β production. Our previous work demonstrated that newly synthesized BACE1 and APP are segregated into distinct traff...
The dendritic ERGIC: Microtubule and actin cytoskeletons participate in stop-and-go movement of mobile carriers between stable structures [0.03%]
树状的ERGIC：微管和肌动蛋白细胞骨架参与稳定结构之间的移动载体的停走运动
María de Los Ángeles Juricic Urzúa,Javiera Gallardo Rojas,Andrés Couve Correa et al.
María de Los Ángeles Juricic Urzúa et al.
The endoplasmic reticulum (ER)-to-Golgi intermediate compartment (ERGIC) is a membranous organelle that mediates protein transport between the ER and the Golgi apparatus. In neurons, clusters of these vesiculotubular structures are situated...
ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans [0.03%]
ERGIC2和ERGIC3调节后生动物中连接蛋白从内质网到高尔基体的运输
Liying Guan,Yongzhi Yang,Jingjing Liang et al.
Liying Guan et al.
The extremely dynamic life cycle of gap junction connections requires highly efficient intracellular trafficking system especially designed for gap junction proteins, but the underlying mechanisms are largely unknown. Here, we identified th...
Bro1 binds the Vps20 subunit of ESCRT-III and promotes ESCRT-III regulation by Doa4 [0.03%]
Bro1结合Vps20（ESCRT-III的一个亚基）并促进Doa4对ESCRT-III的作用
Dalton Buysse,Matt West,Mitchell Leih et al.
Dalton Buysse et al.
The budding of intralumenal vesicles (ILVs) at endosomes requires membrane scission by the ESCRT-III complex. This step is negatively regulated in yeast by Doa4, the ubiquitin hydrolase that deubiquitinates transmembrane proteins sorted as ...
Phosphoinositides containing stearic acid are required for interaction between Rho GTPases and the exocyst to control the late steps of polarized exocytosis [0.03%]
含有硬脂酸的磷脂肌醇磷酸盐是调控极性分泌晚期步骤的Rho GTP酶与exocyst相互作用所必需的
Patricia Laquel,Eric Testet,Karine Tuphile et al.
Patricia Laquel et al.
Cell polarity is achieved by regulators such as small G proteins, exocyst members and phosphoinositides, with the latter playing a key role when bound to the exocyst proteins Sec3p and Exo70p, and Rho GTPases. This ensures asymmetric growth...
Bioinformatic reanalysis of public proteomics data reveals that nuclear proteins are recurrent in cancer secretomes [0.03%]
公共蛋白质组学数据的生物信息学重新分析揭示了核蛋白在癌症分泌组中反复出现
Juliana A De Morais,André Zelanis
Juliana A De Morais
Proteins secreted by tumoral cells (cancer secretomes) have been continuously associated with cancer development and progression processes. In this context, secreted proteins contribute to the signaling mechanisms related to tumor growth an...
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum [0.03%]
胶原在内质网的高效输出中对SEC24有着独特的偏好性
Chung-Ling Lu,Steven Ortmeier,Jon Brudvig et al.
Chung-Ling Lu et al.
SEC24 is mainly involved in cargo sorting during COPII vesicle assembly. There are four SEC24 paralogs (A-D) in vertebrates, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mutations in SEC24D cause osteogenesi...
Hepatitis C virus core protein uses triacylglycerols to fold onto the endoplasmic reticulum membrane [0.03%]
丙型肝炎病毒核心蛋白利用甘油三酯折叠到内质网膜上
Dalila Ajjaji,Kalthoum Ben M&#x;barek,Bertrand Boson et al.
Dalila Ajjaji et al.
Lipid droplets (LDs) are involved in viral infections, but exactly how remains unclear. Here, we study the hepatitis C virus (HCV) whose core capsid protein binds to LDs but is also involved in the assembly of virions at the endoplasmic ret...
Phospholipase D and retromer promote recycling of TRPL ion channel via the endoplasmic reticulum [0.03%]
磷脂酶D和retromer通过内质网促进TRPL离子通道的回收
Krystina Wagner,Thomas K Smylla,Marko Lampe et al.
Krystina Wagner et al.
Plasma membrane protein trafficking is of fundamental importance for cell function and cell integrity of neurons and includes regulated protein recycling. In this work, we report a novel role of the endoplasmic reticulum (ER) for protein re...
The E-Syt3 cleavage and traffic uncovers the primordial cisterna, a new organelle that mothers the lipid droplets in the adipocyte [0.03%]
E-Syt3的裂解和运输揭示了原始扁平囊，这是一种新的细胞器，在脂肪细胞中产生脂滴母体
Vasiliki Lalioti,Galina V Beznoussenko,Alexander A Mironov et al.
Vasiliki Lalioti et al.
Extended synaptotagmins are endoplasmic reticulum proteins consisting of an SMP domain and multiple C2 domains that bind phospholipids and Ca2+ . E-Syts create contact junctions between the ER and plasma membrane (PM) to facilitate the exch...