Extracellular 20S proteasome secreted via microvesicles can degrade poorly folded proteins and inhibit Galectin-3 agglutination activity [0.03%]
胞外20S蛋白酶体通过微泡分泌并降解错误折叠的蛋白质及抑制半乳糖凝集素-3聚集活性
Anne Bonhoure,Laurent Henry,Claudia Bich et al.
Anne Bonhoure et al.
Proteasomes are major non-lysosomal proteolytic complexes localized in the cytoplasm and in the nucleus of eukaryotic cells. Strikingly, high levels of extracellular proteasome have also been evidenced in the plasma (p-proteasome) of patien...
Arabidopsis synaptotagmin 1 mediates lipid transport in a lipid composition-dependent manner [0.03%]
拟南芥Synaptotagmin 1以磷脂组成依赖的方式介导脂质运输
Tiantian Qian,Chenlu Li,Furong Liu et al.
Tiantian Qian et al.
The endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCSs) are structurally conserved in eukaryotes. The Arabidopsis ER-anchored synaptotagmin 1 (SYT1), enriched in EPCSs, plays a critical role in plant abiotic stress toleran...
Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalization [0.03%]
黑素通过角质形成细胞的发生性吞噬作用发生并涉及蛋白酶激活受体-2的内吞作用
Hugo Moreiras,Liliana Bento-Lopes,Matilde V Neto et al.
Hugo Moreiras et al.
In the skin epidermis, melanin is produced and stored within melanosomes in melanocytes, and then transferred to keratinocytes. Different models have been proposed to explain the melanin transfer mechanism, which differ essentially in how m...
CD14 recycling modulates LPS-induced inflammatory responses of murine macrophages [0.03%]
CD14循环调节小鼠巨噬细胞中LPS诱导的炎症反应
Anna Ciesielska,Marta Krawczyk,Hanna Sas-Nowosielska et al.
Anna Ciesielska et al.
TLR4 is activated by the bacterial endotoxin lipopolysaccharide (LPS) and triggers two proinflammatory signaling cascades: a MyD88-dependent one in the plasma membrane, and the following TRIF-dependent one in endosomes. An inadequate inflam...
Current methods to analyze lysosome morphology, positioning, motility and function [0.03%]
用于分析溶酶体形态、定位、运动和功能的当前方法
Duarte C Barral,Leopoldo Staiano,Cláudia Guimas Almeida et al.
Duarte C Barral et al.
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles. Lysosomes were regarded as exclusively degradative organelles, but more recent research has shown that they play essenti...
Loss of intermediate filament IFB-1 reduces mobility, density, and physiological function of mitochondria in Caenorhabditis elegans sensory neurons [0.03%]
中间丝IFB-1的丧失降低了秀丽隐杆线虫感觉神经元中线粒体的运动性、密度和生理功能
Syed Nooruzuha Barmaver,Muniesh Muthaiyan Shanmugam,Yen Chang et al.
Syed Nooruzuha Barmaver et al.
Mitochondria and intermediate filament (IF) accumulations often occur during imbalanced axonal transport leading to various types of neurological diseases. It is still poorly understood whether a link between neuronal IFs and mitochondrial ...
Endosomes supporting fusion mediated by vesicular stomatitis virus glycoprotein have distinctive motion and acidification [0.03%]
介导病毒融合的内体具有独特运动和酸化特征
Maya Cabot,Volker Kiessling,Judith M White et al.
Maya Cabot et al.
Most enveloped viruses infect cells by binding receptors at the cell surface and undergo trafficking through the endocytic pathway to a compartment with the requisite conditions to trigger fusion with a host endosomal membrane. Broad catego...
Getting on the right track: Interactions between viruses and the cytoskeletal motor proteins [0.03%]
正中靶心：病毒与细胞骨架马达蛋白的相互作用
Clàudia Río-Bergé,Yingying Cong,Fulvio Reggiori
Clàudia Río-Bergé
The cytoskeleton is an essential component of the cell and it is involved in multiple physiological functions, including intracellular organization and transport. It is composed of three main families of proteinaceous filaments; microtubule...
Distribution of membrane trafficking system components across ciliate diversity highlights heterogenous organelle-associated machinery [0.03%]
膜 trafficking 组件的分布展示了纤毛虫多样性和异质性器官相关机器
Elisabeth Richardson,Joel B Dacks
Elisabeth Richardson
The ciliate phylum is a group of protists noted for their unusual membrane trafficking system and apparent environmental ubiquity; as highly successful microbial predators, they are found in all manner of environments and the ability for sp...
Vps501, a novel vacuolar SNX-BAR protein cooperates with the SEA complex to regulate TORC1 signaling [0.03%]
新型囊泡SNX-BAR蛋白Vps501与SEA复合物协作调节TORC1信号转导
Shreya Goyal,Verónica A Segarra,Nitika et al.
Shreya Goyal et al.
The sorting nexins (SNX), constitute a diverse family of molecules that play varied roles in membrane trafficking, cell signaling, membrane remodeling, organelle motility and autophagy. In particular, the SNX-BAR proteins, a SNX subfamily c...