Copper Homeostasis at the Crossroads of Cellular Metabolism, Epigenetic Regulation and Protein Trafficking [0.03%]
铜离子稳态调节细胞代谢、表观遗传和蛋白质转运的机制及其在疾病发生中的作用
Vandana Anjana,Smriti Anand,Prateeksha Thakur et al.
Vandana Anjana et al.
Copper is one of the essential micronutrients utilized as a cofactor in a wide variety of biochemical reactions of metabolic pathways, including mitochondrial respiration and innate immune response. Cellular concentration and distribution o...
The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy [0.03%]
小型细胞外囊泡在肿瘤发生中的作用及其靶向治疗前景
Yinan Yu,Shengjie Wang,Rong Ji et al.
Yinan Yu et al.
Small extracellular vesicles (sEVs) originate from endosomes formed during cellular endocytosis, have a diameter ranging from 30 to 150 nm and are membrane-bound prior to release, sEVs may also be formed by budding of the plasma membrane to...
Ruey-Hwa Chen,Antonio J Costa-Filho,Jayanta Debnath et al.
Ruey-Hwa Chen et al.
In eukaryotes, protein secretion plays essential roles in intercellular communications and extracellular niche-building. Protein secretion generally requires a signal sequence that targets cargos to the canonical secretory pathway consistin...
Virion Associated Importin Subunit Beta-1 Augments Nuclear Import of HIV-1 Pre-Integration Complex [0.03%]
衣壳相关异二聚体进口蛋白亚基β-1增强HIV-1前整合复合物的核输入
Sriram Yandrapally,Satarupa Sarkar,Venkateshwarlu Naik et al.
Sriram Yandrapally et al.
Import of proviral genome from the cytoplasm to the nucleus is a decisive step in the HIV-1 infection cycle, regulating which can decide the fate of HIV-1 infectivity. Exploring the heterogeneity in the replication potential of viruses emer...
Samuele Ghignoli,Valentina De Lorenzi,Gianmarco Ferri et al.
Samuele Ghignoli et al.
The secretion of insulin and glucagon by pancreatic β and α cells, respectively, is critical for glucose homeostasis. While the insulin granule dynamics are well-characterized, the intracellular behavior of glucagon secretory granules (GS...
Strain-Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi-Infected Macrophages [0.03%]
应激反应依赖的溶组织内阿米巴感染巨噬细胞来源的小细胞外囊泡的免疫信号作用
Andrea C Mesías,María Elisa Vázquez,Maximiliano Cosenza et al.
Andrea C Mesías et al.
Among extracellular vesicles (EVs), exosomes, comprised within small EVs are bilayered nanovesicles carrying specific cargo that are released into the interstitial space in a highly regulated manner. In this study, we investigated the messa...
From Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and Treatment [0.03%]
从机制到治疗：探究铁死亡在宫颈癌转化和治疗中的作用
Zhenlei Wang,Yuanyuan Xiao,Ranzhong Chen et al.
Zhenlei Wang et al.
Cervical cancer (CC) exerts a considerable impact on women's health worldwide and presents persistent challenges to conventional therapeutic strategies due to its propensity for distant metastasis, postoperative recurrence, and variable dru...
FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway [0.03%]
FGF信号通过甘露糖-6-磷酸受体通路促进软骨细胞溶酶体生成
Laura Cinque,Maria Iavazzo,Gennaro Di Bonito et al.
Laura Cinque et al.
The mannose 6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeleto...
CIN85 and CD2AP Are Novel Constituents of Dynamic Tubular Recycling Endosomes That Regulate Recycling Upon Recruitment by MICAL-L1 [0.03%]
CIN85和CD2AP是动态管状回肠循环内吞体的新型组成成分，通过MICAL-L1募集调节循环作用
Gunjan Misri,Ajay B Murakonda,Naava Naslavsky et al.
Gunjan Misri et al.
Recycling endosomes are essential for membrane trafficking, retrieving internalized cell surface receptors and lipids to the plasma membrane. In this study, we investigate the dynamics of tubular recycling endosomes (TREs) and their regulat...
Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases [0.03%]
存在于真核生物中的囊泡转运的小G蛋白解离激活因子(longin)结构域含蛋白家族的新成员
Anna M G Novák Vanclová,Catherine L Jackson,Joel B Dacks
Anna M G Novák Vanclová
Arf and Rab family small GTPases and their regulators, GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), play a central role in membrane trafficking. In this study, we focused on a recently reported GAP for A...