Discovery Begets Discovery: Special Edition on Melatonin and the Musculoskeletal System [0.03%]
褪黑素与肌肉骨骼系统发现之旅特别版：发现孕育新的发现
Paula A Witt-Enderby
Paula A Witt-Enderby
Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function [0.03%]
褪黑素通过下调ABCB1表达和调节线粒体功能来克服癌症多药耐药性
Alba López-Rodríguez,Laura Martinez-Ruiz,Raquel Morales-Gallel et al.
Alba López-Rodríguez et al.
Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. A critical factor contributing to MDR is overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1. Novel alternative therapeutic strategies are needed t...
Key Role of the CRE Sequence in the Per1 Promoter in Mediating the Switch Between Unipolar and Bipolar Depression-Like Behaviors [0.03%]
CRE序列在Per1启动子中的关键作用介导单相抑郁样行为和双相抑郁样行为的转换
Xin-Ling Wang,Xuan Tan,Ke Wang et al.
Xin-Ling Wang et al.
The cAMP response element-binding protein (CREB) and Period1 (Per1) have been implicated in depression, but their interactive mechanisms remain unclear. This study investigated the integrative role of CREB and Per1 in depression and explore...
Liquid-Liquid Phase Separation of AR Orchestrated by Melatonin Sensitizes Prostate Cancer to Ferroptosis Via MCM5/NRF2 Axis Collapse [0.03%]
褪黑素诱导的AR液-液相分离通过破坏MCM5/NRF2轴使前列腺癌对铁死亡敏感化
Xianyanling Yi,Zeyu Han,Yaxiong Tang et al.
Xianyanling Yi et al.
The treatment of prostate cancer (PCa) remains challenging, and while melatonin (MEL) has demonstrated therapeutic potential, its precise mechanisms require further elucidation. Through integrated in vitro, in vivo, and bioinformatics analy...
Melatonin Inhibits Antibody-Secreting Cells and Improves Systemic Lupus Erythematosus via Modulation of the PKA-CREB Signaling Pathway [0.03%]
褪黑素通过调节PKA-CREB信号通路抑制浆细胞产生并改善系统性红斑狼疮
Pei Du,Yaqin Yu,Wenqian Zhang et al.
Pei Du et al.
Systemic lupus erythematosus (SLE) is an autoimmune disorder featuring abnormal B cell differentiation and excessive autoantibody production, leading to multiorgan damage. Despite advances in understanding SLE pathogenesis, the molecular me...
Melatonin Modulates Copper Homeostasis Through NO Dependent Manner in Rice (Oryza sativa L.) [0.03%]
褪黑素通过依赖NO的方式调节水稻铜稳态
Jing Huang,Hao Yu Wang,Jia Qi Li et al.
Jing Huang et al.
Melatonin (MT) plays a critical role in regulating rice responses to heavy metal stress. However, the mechanism by which MT alleviates copper (Cu) toxicity in rice remains insufficiently understood. In this study, excessive Cu increased end...
Exogenous Melatonin Application Alleviates Microplastics and Cadmium-Induced Phytotoxicity in Maize (Zea mays L.) Plants: Insights From Physiological and Metabolomic Analyses [0.03%]
外源褪黑素缓解微塑料和镉对玉米植株毒害：来自生理和代谢组学分析的见解
Xiliang Song,Yinghui Sun,Sen Yang et al.
Xiliang Song et al.
Soil contamination by microplastics (MPs) and heavy metals has become a global ecological and environmental issue and poses considerable threats to crop production and human health. In plants, melatonin (MT) functions as a powerful biostimu...
Melatonin Membrane Receptors in the Vascular System: Function, Modulation and Clinical Relevance [0.03%]
血管系统中的褪黑素膜受体：功能、调控和临床相关性
Leonardo da Rocha-Carvalho,Ana Carolina Cardoso-Teixeira,José Cipolla-Neto et al.
Leonardo da Rocha-Carvalho et al.
Melatonin (MEL) is a hormone whose secretion is regulated by daily and seasonal environmental light cycles. MEL production is strictly limited to the night and is inhibited by light. Besides exhibiting chronobiotic properties, MEL possesses...
Melatonin Confers Protection Against Multidrug-Resistant Bacterial Infections in Aged Mice Via Microbiota-Derived Butyrate [0.03%]
褪黑素通过肠道菌群衍生的丁酸盐保护老年小鼠抵抗多重耐药细菌感染
Wenjiao Xu,Jiaqi Bo,Liyan Jia et al.
Wenjiao Xu et al.
Aging is associated with increased susceptibility to bacterial infections, particularly multidrug-resistant (MDR) strains, which often result in antibiotic treatment failure and high mortality rates in the elderly. However, effective preven...