Melatonin Confers Protection Against Multidrug-Resistant Bacterial Infections in Aged Mice Via Microbiota-Derived Butyrate [0.03%]
褪黑素通过肠道菌群衍生的丁酸盐保护老年小鼠抵抗多重耐药细菌感染
Wenjiao Xu,Jiaqi Bo,Liyan Jia et al.
Wenjiao Xu et al.
Aging is associated with increased susceptibility to bacterial infections, particularly multidrug-resistant (MDR) strains, which often result in antibiotic treatment failure and high mortality rates in the elderly. However, effective preven...
Pilot Study Assessing the Efficacy of Melatonin and Osteogenic Loading on Bone Health in a Postmenopausal Population with Osteopenia: MelaOstrong Randomized Controlled Trial [0.03%]
评估褪黑激素和成骨负载对绝经后骨质疏松人群骨健康影响的试点研究：随机对照试验MelaOstrong
Afsana Jahan,Yong Myoung,Afsin Malik et al.
Afsana Jahan et al.
The purpose of this 1-year study was to assess the effect of osteogenic loading combined with melatonin on musculoskeletal health and well-being in a population with osteopenia. Participants were randomized into one of four groups and recei...
Randomized Controlled Trial
Journal of pineal research. 2025 Nov;77(6):e70088. DOI:10.1111/jpi.70088 2025
The Mechanism by Which Melatonin Improves the Dysregulation of Glucose and Lipid Metabolism in Castrated Female Mice [0.03%]
褪黑素改善去势大鼠糖脂代谢紊乱的机制研究
Xin Jin,Xuan Liu,Yunjuan Wang et al.
Xin Jin et al.
Postmenopausal women have a significantly increased risk of cardiovascular disease and osteoporosis due to the lack of estrogen protection. To explore the effects of melatonin on clock genes and glucose and lipid metabolic disorders of post...
Melatonin-Producing Microorganisms: A Rising Research Interest in Their Melatonin Biosynthesis and Effects on Crops [0.03%]
产褪黑素微生物：它们的褪黑素生物合成及对农作物的影响研究日益增多
Sang-Mo Kang,Ashim Kumar Das,Da-Sol Lee et al.
Sang-Mo Kang et al.
Melatonin is imperative in animals and plants, contributing to multiple physiological roles, and its microbial production could offer an eco-friendly alternative to synthetic melatonin. However, detecting and characterizing it in microorgan...
Circadian Misalignment as a Determinant of Insomnia Severity: Possible Implications in Sleep Medicine Clinical Practice [0.03%]
昼夜节律失调与失眠严重程度的关系及其在睡眠医学临床实践中的意义
Alessandro Colitta,Ugo Faraguna
Alessandro Colitta
In this letter to the editor, we comment on the recently published study from Scott et al. (2025), which highlights circadian misalignment as a possible determinant of insomnia severity. Considering the robust methodology of this study and ...
Relationship Between Urinary 6-Sulfatoxymelatonin Rhythms and the Bone Resorption Marker Amino-Terminal Cross-Linked Telopeptide of Collagen I in Blind Women [0.03%]
盲人女性尿液6-硫酸水杨胺节律与骨吸收标志物I型胶原交联N末端肽关系研究
Melissa A St Hilaire,Erin E Flynn-Evans,Shadab A Rahman et al.
Melissa A St Hilaire et al.
Evidence exists for the daily rhythmicity of bone metabolism that may be influenced by melatonin production, reproductive hormones, the light/dark cycle, or all three, but the ability to determine their independent contributions is confound...
Sequence Symmetry Analysis of the Interrelationships Between Ramelteon and Parkinson's Disease [0.03%]
瑞美隆与帕金森病之间互作关系的序列对称性分析
Yoshihiro Noguchi,Rikuto Masuda,Tomoaki Yoshimura
Yoshihiro Noguchi
Parkinson's disease is the second most frequent neurodegenerative disease after Alzheimer's disease, and the most common neurodegenerative disease that causes movement dysfunction. Without innovations in prevention and treatment, the incide...