Adaptations of the aging animal to exercise: role of daily supplementation with melatonin [0.03%]
褪黑素日常补充对运动老龄动物的适应性作用
Caroline Mendes,Ana Maria de Souza Lopes,Fernanda Gaspar do Amaral et al.
Caroline Mendes et al.
The pineal gland, through melatonin, seems to be of fundamental importance in determining the metabolic adaptations of adipose and muscle tissues to physical training. Evidence shows that pinealectomized animals fail to develop adaptive met...
Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells [0.03%]
褪黑素通过ER应激介导INS-1E细胞中胰岛素合成涉及HuD表达的作用机制研究
Yeong-Min Yoo
Yeong-Min Yoo
In this study, we investigated how melatonin mediates insulin synthesis through endoplasmic reticulum (ER) via HuD expression in rat insulinoma INS-1E cells. Under ER stress condition (thapsigargin with/without melatonin, tunicamycin with/w...
Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin [0.03%]
褪黑素通过增加C/EBP同源蛋白并降低存活素的表达逆转白地霉毒素诱导的人肝癌细胞内质网应激及改善其对多柔比星的毒性反应
Lulu Fan,Guoping Sun,Tai Ma et al.
Lulu Fan et al.
Chemoresistance in hepatocellular carcinoma (HCC) is associated with multiple cellular responses to environmental stresses, such as nutrient deprivation and hypoxia. Nevertheless, whether ER stress resulting from nutrient deprivation and tu...
Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin [0.03%]
褪黑素通过降低内质网应激和调节未折叠蛋白反应治疗病毒性急性重型肝炎的兔模型研究
María J Tuñón,Beatriz San-Miguel,Irene Crespo et al.
María J Tuñón et al.
Hepatocyte apoptosis plays an important role in the development of fulminant hepatic failure (FHF). The objective of this study was to investigate whether endoplasmic reticulum (ER) stress and unfolded protein response (UPR) inhibition is a...
Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP [0.03%]
褪黑素通过靶向Survivin和XIAP克服人类肝癌细胞的凋亡耐药性
Lulu Fan,Guoping Sun,Tai Ma et al.
Lulu Fan et al.
Apoptosis resistance in hepatocellular carcinoma (HCC) is one of the most significant factors for hepatocarcinogenesis and tumor progression, and leads to resistance to conventional chemotherapy. It is well known that inhibitor of apoptosis...
Melatonin, given at the time of reperfusion, prevents ventricular arrhythmias in isolated hearts from fructose-fed rats and spontaneously hypertensive rats [0.03%]
褪黑素在再灌注时给药可预防果糖喂养大鼠和自发性高血压大鼠分离心脏的室性心律失常
Emiliano Raúl Diez,Nicolás Federico Renna,Natalia Jorgelina Prado et al.
Emiliano Raúl Diez et al.
Melatonin reduces reperfusion arrhythmias when administered before coronary occlusion, but in the clinical context of acute coronary syndromes, most of the therapies are administered at the time of reperfusion. Patients frequently have phys...
H Garcia-Moreno,J R Calvo,M D Maldonado
H Garcia-Moreno
Beer is a beverage consumed worldwide. It is produced from cereals (barley or wheat) and contains a wide array of bioactive phytochemicals and nutraceutical compounds. Specifically, high melatonin concentrations have been found in beer. Bee...
H Garcia-Moreno,J R Calvo,M D Maldonado
H Garcia-Moreno
Beer is a beverage consumed worldwide. It is produced from cereals (barley or wheat) and contains a wide array of bioactive phytochemicals and nutraceutical compounds. Specifically, high melatonin concentrations have been found in beer. Bee...
Growth conditions determine different melatonin levels in Lupinus albus L [0.03%]
生长条件决定白 lupinus albus l 的不同褪黑素水平
Marino B Arnao,Josefa Hernández-Ruiz
Marino B Arnao
Melatonin, an indoleamine, which has recently been assigned several roles in plant physiology as a growth promoter, as rooting agent, and as antioxidant in senescence delay and cytoprotection, seems to have a relevant function in plant stre...
Melatonin improves insulin sensitivity independently of weight loss in old obese rats [0.03%]
褪黑素可独立于体重减轻改善年老肥胖大鼠的胰岛素敏感性
Ricardo Zanuto,Mário A Siqueira-Filho,Luciana C Caperuto et al.
Ricardo Zanuto et al.
In aged rats, insulin signaling pathway (ISP) is impaired in tissues that play a pivotal role in glucose homeostasis, such as liver, skeletal muscle, and adipose tissue. Moreover, the aging process is also associated with obesity and reduct...