Exogenous Melatonin Regulates Hormone Signalling and Photosynthesis-Related Genes to Enhance Brassica napus. Yield: A Transcriptomic Perspective [0.03%]
外源褪黑素通过调节激素信号和光合作用相关基因提高油菜产量——基于转录组学视角的研究
Sana Basharat,Wajid Saeed,Samavia Mubeen et al.
Sana Basharat et al.
Melatonin, a multifunctional signalling molecule in plants, has been increasingly recognized for its role in improving stress tolerance, regulating hormone signalling, and enhancing crop productivity. Exogenous melatonin application represe...
Transcriptomic and Metabolomic Signatures of Acute Circadian Misalignment in Mice [0.03%]
急性昼夜节律失调的小鼠转录组和代谢组特征分析
Baoyin Ren,Yingzhi Huang,Hui Wang et al.
Baoyin Ren et al.
Acute circadian misalignment, such as that induced by a single episode of jet lag, can leave molecular traces even after behavioral rhythms appear to recover. Here, we applied an integrated multi-omics approach-combining liver transcriptomi...
Modeling Genetic Risk of β-Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant [0.03%]
携带有MTNR1B风险等位基因的糖尿病患者诱导多能干细胞中β细胞功能障碍遗传易感性的研究建模
Tania Singh,Sebastian Kalamajski,Joãp P M C M Cunha et al.
Tania Singh et al.
Disruptions in circadian rhythm, partly controlled by the hormone melatonin, increase the risk of type 2 diabetes (T2D). Accordingly, a variant of the gene encoding the melatonin receptor 1B (MTNR1B) is robustly associated with increased ri...
Melatonin Induces PERK-ATF4 Unfolded Protein Response and Apoptosis in Human Choriocarcinoma Cells [0.03%]
褪黑素通过PERK-ATF4未折叠蛋白反应诱导人绒癌细胞凋亡
Josianne Bienvenue-Pariseault,Lucas Sagrillo-Fagundes,Philippe Wong-Yen et al.
Josianne Bienvenue-Pariseault et al.
Melatonin, an indolamine primarily recognized for regulating circadian rhythms, has also demonstrated notable antitumoral properties. Melatonin induces endoplasmic reticulum (ER) stress, modulates autophagy, and promotes apoptosis in variou...
NPAS2 Deficiency Leads to Antidepressant-Like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation [0.03%]
NPAS2缺陷通过调节星形胶质细胞介导的神经炎症导致小鼠抗抑郁样行为
Yiyuan Tian,Jiao Mu,Jiali Ye et al.
Yiyuan Tian et al.
Major Depressive Disorder (MDD) is closely associated with neuroinflammation, but the underlying mechanisms remain to be fully elucidated. This study investigates the role of NPAS2 in mediating neuroinflammation-induced depressive-like beha...
Melatonin Inhibits CD4+T Cell Apoptosis via the Bcl-2/BAX Pathway and Improves Survival Rates in Mice With Sepsis [0.03%]
褪黑素通过Bcl-2/BAX途径抑制CD4+T细胞凋亡并提高脓毒症小鼠的生存率
Zhenggong Li,Huifang Wang,Qiuping Zhou et al.
Zhenggong Li et al.
This study examined whether melatonin could decrease CD4 + T cell apoptosis and reduce mortality rates in sepsis-induced mice. Fifty-one male C57BL/6 mice were randomly classified into three groups: Sham, cecal ligation and puncture (CLP), ...
Circadian Rhythm Timing and Associations With Sleep Symptoms in People With Insomnia [0.03%]
失眠症患者的昼夜节律时相及与睡眠症状的关系
Hannah Scott,Nicole Lovato,Maria Comas et al.
Hannah Scott et al.
Circadian rhythmicity plays a crucial role in regulating sleep timing and continuity, but it may be altered in people with insomnia. This study tested whether dim-light melatonin onset (DLMO) timing is associated with sleep difficulties in ...
Multivariate Data Analysis Methods and Their Application in Lipidomics: A Gentle Comment on Appropriateness and Reliability Criteria [0.03%]
多变量数据分析方法及其在脂质组学中的应用——适当性和可靠性的评价标准商榷
Anna Migni,Desirée Bartolini,Giada Marcantonini et al.
Anna Migni et al.
In response to Yoshiyasu Takefuji's critique regarding the use of Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) in the study "Melatonin Repairs the Lipidome of Human Hepatocytes Exposed to Cd an...
Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases [0.03%]
睡眠、昼夜活动模式及主要慢性疾病的蛋白质组标志物
Jiahe Wei,Hanzhang Wu,Ying Zheng et al.
Jiahe Wei et al.
Rest-activity rhythm and sleep may serve as potential intervention targets for a variety of diseases. However, the underlying biological mechanisms of rest-activity rhythm, sleep, and their proteomic associations with multiple diseases rema...
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis-Induced Lung Injury via Macrophage Metabolic Reprogramming [0.03%]
直接腹腔复苏和褪黑素通过巨噬细胞代谢重组治疗腹部脓毒症引起的肺损伤
Zhirong Zhao,Jiamin Ji,Lan Ming et al.
Zhirong Zhao et al.
Abdominal sepsis and the resultant lung injury lead to high mortality rates, with macrophage metabolic dysfunction and subsequent immune dysregulation being key contributing factors. The clarification of the therapeutic value of direct peri...