Christina Michalaki,Minahil Sharjeel,Jennifer E Cowan
Christina Michalaki
The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self-tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between...
Sabra L Klein
Sabra L Klein
Shannon E Dunn,Nuria Alvarez-Sanchez,Lawrence Steinman
Shannon E Dunn
Multiple sclerosis (MS) is a T helper (Th) cell-mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood an...
Abigail L Tierney,Wallace P Bezerra,Stephanie C Eisenbarth et al.
Abigail L Tierney et al.
Food allergen-specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high-affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple,...
Manish Gupta,Sabra L Klein,William R Bishai
Manish Gupta
Tuberculosis (TB) remains a leading cause of infectious mortality worldwide, disproportionately affecting vulnerable populations and posing significant challenges for global health. Sex profoundly influences TB susceptibility, disease progr...
Priyanka Saminathan,Maija Corey,Alicia Gibbons et al.
Priyanka Saminathan et al.
Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post-infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, prog...
Dissecting Tumor-Associated Tertiary Lymphoid Structure Formation and Maintenance Using Mouse Models [0.03%]
利用小鼠模型剖析肿瘤相关三级淋巴器官的形成与维持机制
Clémence Riffard,Zixi Yin,Kelli A Connolly et al.
Clémence Riffard et al.
The solid tumor microenvironment is a highly complex system shaped by dynamic interactions among immune and non-immune cell populations. The formation and organization of tumor-associated tertiary lymphoid structures (TA-TLS) have been obse...
Sex Differences in Cancer Immunotherapy-Clinical Evidence and Mechanisms With a Focus on NSCLC [0.03%]
免疫治疗中的性别差异：NSCLC为例的临床证据及机制研究
Eva Krieghoff-Henning,Balagopal Pai,Maike Collienne et al.
Eva Krieghoff-Henning et al.
Accumulating evidence suggests that the immune system shows subtle but relevant differences between men and women. These differences may have an impact on cancer development and TME composition as well as responses to and adverse events eli...
Maria Pujantell,Marcus Altfeld
Maria Pujantell
Immune responses are key in controlling viral infections such as HIV-1, which remains a global challenge to public health. X/Y-chromosome-encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene a...