William P Esler,David E Cohen
William P Esler
The hepatic accumulation of excess triglycerides is a seminal event in the initiation and progression of non-alcoholic fatty liver disease (NAFLD). Hepatic steatosis occurs when the hepatic accrual of fatty acids from the plasma and de novo...
Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH [0.03%]
NASH中血管完整性受损与脂肪组织巨噬细胞功能障碍有关
Markus Boesch,Andreas Lindhorst,Rita Feio-Azevedo et al.
Markus Boesch et al.
Background & aims: In non-alcoholic fatty liver disease (NAFLD), monocytes infiltrate visceral adipose tissue promoting local and hepatic inflammation. However, it remains unclear what drives inflammation and how the immu...
Characteristics and outcomes of immunotherapy-related liver injury in patients with hepatocellular carcinoma versus other advanced solid tumours [0.03%]
肝细胞癌与其他晚期实体瘤患者免疫相关肝损伤的特点和转归研究
Ciro Celsa,Giuseppe Cabibbo,Claudia A M Fulgenzi et al.
Ciro Celsa et al.
Background & aims: Immune-related liver injury (irLI) is commonly observed in patients with cancer treated with immune checkpoint inhibitors (ICIs). We aimed to compare the incidence, clinical characteristics, and outcome...
Multicenter Study
Journal of hepatology. 2024 Mar;80(3):431-442. DOI:10.1016/j.jhep.2023.10.040 2024
Convergent MAPK pathway alterations mediate acquired resistance to FGFR inhibitors in FGFR2 fusion-positive cholangiocarcinoma [0.03%]
FGFR抑制剂治疗阳性胆管癌的获得性耐药机制中的收敛MAPK途径改变
Timothy P DiPeri,Ming Zhao,Kurt W Evans et al.
Timothy P DiPeri et al.
Background & aims: There is a knowledge gap in understanding mechanisms of resistance to fibroblast growth factor receptor (FGFR) inhibitors (FGFRi) and a need for novel therapeutic strategies to overcome it. We investiga...
Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module [0.03%]
单细胞解析小鼠MASH高分辨率血管生成稳态调控机制
Sofie M Bendixen,Peter R Jakobsgaard,Daniel Hansen et al.
Sofie M Bendixen et al.
Background & aims: Metabolic dysfunction-associated steatohepatitis (MASH) is linked to insulin resistance and type 2 diabetes and marked by hepatic inflammation, microvascular dysfunction, and fibrosis, impairing liver f...
An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1 [0.03%]
一株工程改造的希氏大肠杆菌尼丝莱菌株可预防酪氨酸血症I型小鼠模型出现致命性肝损伤
Peng Gu,Li Xie,Tao Chen et al.
Peng Gu et al.
Background & aims: Hereditary tyrosinemia type 1 (HT1) results from the loss of fumarylacetoacetate hydrolase (FAH) activity and can lead to lethal liver injury. Therapeutic options for HT1 remain limited. In this study, ...
Current evidence on the beneficial HOPE-effect based on systematic reviews and meta-analyses in liver transplantation [0.03%]
基于系统评价和荟萃分析的肝脏移植HOPE阳性效应的现有证据
Alessandro Parente,Daniele Dondossola,Philipp Dutkowski et al.
Alessandro Parente et al.
Stop using the misidentified cell line LO2 as a human hepatocyte [0.03%]
停止使用错误识别的LO2肝癌细胞系作为人正常肝细胞的研究模型论文发表
Ting Shao,Yue-Lei Chen
Ting Shao
Inflammatory bowel disease and primary sclerosing cholangitis: One disease or two? [0.03%]
炎症性肠病和原发性硬化性胆管炎：一种疾病还是一组疾病的两种表现？
Kim N van Munster,Annika Bergquist,Cyriel Y Ponsioen
Kim N van Munster
Primary sclerosing cholangitis (PSC) was declared one of the biggest unmet needs in hepatology during International Liver Congress 2016 in Berlin. Since then, not much has changed unfortunately, largely due to the still elusive pathophysiol...
Patients with hepatocellular carcinoma and portal vein tumour thrombosis after successful downstaging may be candidates for liver transplantation: A meta-analysis [0.03%]
成功的降级治疗后，肝细胞癌伴门静脉瘤栓患者可能适合进行肝脏移植：一项荟萃分析
Jianpeng Liu,Junjie Qian,Zhe Yang et al.
Jianpeng Liu et al.