Antibodies elicited by hepatitis E vaccination in humans confer cross-genus protection against rat hepatitis E virus [0.03%]
人类接种戊型肝炎疫苗后产生的抗体对鼠戊型肝炎病毒具有交叉保护作用
Zihao Chen,Liqin Liu,Jianwen Situ et al.
Zihao Chen et al.
Background & aims: Paslahepevirus balayani (bHEV), also known as hepatitis E virus (HEV), encompasses eight genotypes, five of which infect humans. Rats are natural reservoirs of Rocahepevirus ratti genotype 1 (HEV-r-1; r...
Impact of first and further decompensation in patients with compensated ACLD due to MASLD [0.03%]
代偿期肝硬化的患者首次失代偿及进一步失代偿的影响因素分析
Grazia Pennisi,Gabriele Di Maria,Vincent Wai-Sun Wong et al.
Grazia Pennisi et al.
Background&aim: The first and further decompensation mark the natural history and the risk of mortality in patients with cirrhosis. We assessed the cumulative incidence of first and further (acute and non-acute) decompens...
Glucagon controls obesity-specific energy expenditure via persistent cAMP/PKA signaling [0.03%]
长效cAMP/PKA信号通过胰高血糖素控制肥胖特异性能量消耗
Fen Long,Tenagne Delessa Challa,Lianggong Ding et al.
Fen Long et al.
Background & aims: Glucagon (GCG) analogues are gaining attention as promising components in incretin-based therapeutics for obesity and metabolic dysfunction-associated steatohepatitis. However, the biology of chronic gl...
Rapid whole-blood immune profiling reveals heterogeneous HBV-specific T cell response patterns independent of clinical disease phases [0.03%]
快速的全血免疫谱系分析揭示了与临床疾病阶段无关的异质性乙肝病毒特异性T细胞反应模式
Nina Le Bert,Apostolos Koffas,Rajneesh Kumar et al.
Nina Le Bert et al.
Background & aims: There is an unmet need for immunological biomarkers in chronic hepatitis B (CHB), where patient management relies on virological and biochemical markers despite the crucial role of virus-specific T cell...
Ulrich Beuers,Jesus M Banales,Saul Karpen et al.
Ulrich Beuers et al.
Animal bile has been regarded as a potential remedy of liver diseases for millennia in ancient Eastern cultures. The application of bile acids as major organic bile components for gallstone dissolution and of ursodeoxycholic acid (UDCA) for...
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies [0.03%]
胆酸通过SIPR-STAT3信号轴调节纤维化胆病中的调节性T细胞应答
Ramesh Kudira,Zi F Yang,Immaculeta Osuji et al.
Ramesh Kudira et al.
Background & aim: Regulatory T cells (Tregs), a subset of CD4 lymphocytes, protect from inflammatory tissue injury. How retention of bile acids (BA) in fibrosing cholangiopathies like biliary atresia or primary sclerosing...
Chimeric Antigen Receptor (CAR) T-cell Therapy: Engineering Immune Cells To Treat Liver Diseases [0.03%]
嵌合抗原受体T细胞治疗：工程改造免疫细胞以治疗肝脏疾病
Elmar Jaeckel,Scott L Friedman,Michael Hudecek et al.
Elmar Jaeckel et al.
Endogenous T cells recognize antigens through human leukocyte antigen (HLA)/peptide complexes. However, the polymorphism of HLA has posed significant challenges to the development of broadly applicable adoptive T-cell therapies. Engineered ...
Efficacy and safety of time-restricted eating in metabolic dysfunction-associated steatotic liver disease [0.03%]
限时饮食对于代谢功能异常相关肝脂肪变性的疗效和安全性研究
Joo Hyun Oh,Eileen L Yoon,Huiyul Park et al.
Joo Hyun Oh et al.
Background & aims: Time-restricted eating (TRE) may improve weight loss, insulin resistance, and body composition, key factors in the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD). Ho...
Polyunsaturated fatty acid-induced metabolic exhaustion and ferroptosis impair the anti-tumour function of MAIT cells in MASLD [0.03%]
多不饱和脂肪酸诱导的代谢衰竭和铁死亡损害MAIT细胞在MASLD中的抗肿瘤功能
Sebastian Deschler,Junika Pohl-Topcu,Lukas Ramsauer et al.
Sebastian Deschler et al.
Background & aims: Mucosal-associated invariant T (MAIT) cells constitute a highly abundant innate-like T cell population in the human liver that is critical for immune surveillance of hepatic cancers but often dysfunctio...