Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism [0.03%]
SLC25A15基因缺失通过重新编程谷氨酰胺代谢促进肝细胞癌发生发展
Qiangnu Zhang,Teng Wei,Wen Jin et al.
Qiangnu Zhang et al.
Background & aims: The role of solute carrier family 25 member 15 (SLC25A15), a critical component of the urea cycle, in hepatocellular carcinoma (HCC) progression remains poorly understood. This study investigated the im...
CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis [0.03%]
CD1d保护非酒精性脂肪性肝炎中的肝细胞免于凋亡
Zhigang Lei,Jiaojiao Yu,Yu Wu et al.
Zhigang Lei et al.
Background & aims: Hepatocyte apoptosis, a well-defined form of cell death in non-alcoholic steatohepatitis (NASH), is considered the primary cause of liver inflammation and fibrosis. However, the mechanisms underlying th...
Using liver stiffness to predict and monitor the risk of decompensation and mortality in patients with alcohol-related liver disease [0.03%]
利用肝脏硬度预测和监测酒精相关肝病患者失代偿和死亡的风险
Katrine Holtz Thorhauge,Georg Semmler,Stine Johansen et al.
Katrine Holtz Thorhauge et al.
Background & aims: Liver stiffness measurement (LSM) is recommended for disease prognostication and monitoring. We evaluated if LSM, using transient elastography, and LSM changes predict decompensation and mortality in pa...
Observational Study
Journal of hepatology. 2024 Jul;81(1):23-32. DOI:10.1016/j.jhep.2024.02.019 2024
PTEN deficiency induces an extrahepatic cholangitis-cholangiocarcinoma continuum via aurora kinase A in mice [0.03%]
PTEN缺乏通过aurora激酶A诱导小鼠发生胆管炎-胆管癌连续病变
Yan Yang,Jiale Wang,Jianhua Wan et al.
Yan Yang et al.
Background & aims: The PTEN-AKT pathway is frequently altered in extrahepatic cholangiocarcinoma (eCCA). We aimed to evaluate the role of PTEN in the pathogenesis of eCCA and identify novel therapeutic targets for this di...
Multi-omics characterization of healthy and PSC human liver - what we knew and what we have learned [0.03%]
健康和PSC人类肝脏的多组学特征-我们已知的和我们学到的
Jenny Krause,Christoph Schramm
Jenny Krause
Multidrug-resistant bacterial infections after liver transplantation: Prevalence, impact, and risk factors [0.03%]
肝脏移植后多重耐药菌感染：流行率、影响和危险因素
Rosa Martin-Mateos,Laura Martínez-Arenas,Ángela Carvalho-Gomes et al.
Rosa Martin-Mateos et al.
Background & aims: Infections by multidrug-resistant bacteria (MDRB) are an increasing healthcare problem worldwide. This study analyzes the incidence, burden, and risk factors associated with MDRB infections after liver ...
Multicenter Study
Journal of hepatology. 2024 Jun;80(6):904-912. DOI:10.1016/j.jhep.2024.02.023 2024
Single-cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity [0.03%]
功能性治愈的慢性乙型肝炎患者的单细胞图谱揭示了固有免疫的激活和CD4-CTL驱动的适应性免疫改变
Balakrishnan Chakrapani Narmada,Atefeh Khakpoor,Niranjan Shirgaonkar et al.
Balakrishnan Chakrapani Narmada et al.
Background & aims: Hepatitis B surface antigen (HBsAg) loss or functional cure (FC) is considered the optimal therapeutic outcome for patients with chronic hepatitis B (CHB). However, the immune-pathological biomarkers an...
The transition from NAFLD to MASLD and its impact on clinical practice and outcomes [0.03%]
从非酒精性脂肪肝到代谢相关脂肪性肝病的转变及其对临床实践和结局的影响
Zhenhua Lu,Weiwei Shao,Jinghai Song
Zhenhua Lu
Should MMF treatment be the first-line therapy in autoimmune hepatitis? [0.03%]
自身免疫性肝炎的一线治疗应是MMF治疗吗？
Laurent Alric
Laurent Alric
Autoimmune hepatitis: Azathioprine or mycophenolate mofetil for inducing remission? [0.03%]
自身免疫性肝炎：用硫唑嘌呤还是吗替麦考酚酯诱导缓解？
Avinash Tiwari,Duncan Khanikar,Santosh Govind Rathod
Avinash Tiwari