Hepatic stellate cells regulate multiple aspects of hepatocyte function in health and disease [0.03%]
肝星状细胞在健康和疾病状态下调节肝细胞的多种功能
Prakash Ramachandran
Prakash Ramachandran
Zobair M Younossi,Shira Zelber-Sagi,Aleksander Krag
Zobair M Younossi
Mechanisms and Management of Graft In- and Out-flow in Liver Transplantation: A Narrative Review of the Literature and Guide for Interventional Management [0.03%]
肝移植中移植物灌注和流出机制及管理：文献综述及介入治疗指南
Chase J Wehrle,Masato Fujiki,Sangeeta Satish et al.
Chase J Wehrle et al.
Background and aims: Management of the dual vascular supply of liver grafts in liver transplantation (LT) is increasingly recognized as crucial to achieving adequate graft function. We aim to review how the relationship b...
Prevalence, severity and determinants of steatotic liver disease among individuals with metabolic and alcohol risk from the community [0.03%]
社区代谢和饮酒相关风险人群中的肝脂肪变性流行病学、严重程度及影响因素
Camilla Dalby Hansen,Johanne Kragh Hansen,Mads Israelsen et al.
Camilla Dalby Hansen et al.
Background & aims: Individuals with steatotic liver disease (SLD) are affected by metabolic dysfunction and/or high alcohol consumption; however, the prevalence of SLD in at-risk individuals remains underexplored. In at-r...
Somatic loss-of-function mutations in CIDEB reduce hepatic steatosis by increasing lipolysis and fatty acid oxidation [0.03%]
CIDEB体细胞功能丧失突变通过增加脂解和脂肪酸氧化减少肝脂质沉积
Qiyu Zeng,Satish Patel,Xun Wang et al.
Qiyu Zeng et al.
Background & aims: Somatic and germline CIDEB mutations are associated with protection from chronic liver diseases. The mechanistic basis and whether CIDEB suppression would be an effective therapy against fatty liver dis...
Spatiotemporal liver dynamics shape hepatocellular heterogeneity and impact in vivo gene engineering [0.03%]
时空肝脏动力学塑造肝细胞异质性并影响体内基因工程
Michela Milani,Francesco Starinieri,Stefano Beretta et al.
Michela Milani et al.
Background and aims: Hepatocytes are the primary cells of the liver, essential for metabolism and important targets for in vivo gene therapy, which has the potential to treat monogenic diseases caused by defects in their ...
The role of liver biopsy in diagnosing patients with autoimmune hepatitis- it can be acceptable to skip! [0.03%]
自身免疫性肝炎患者的诊断中肝脏穿刺活检的作用--可以省略！
Einar Stefan Björnsson,Gideon M Hirschfield
Einar Stefan Björnsson
Staging decompensated cirrhosis: Lumping, splitting, or just rearranging the deck chairs on the Titanic? [0.03%]
肝硬化的临床分期：合并、分解，还是在沉船上重新排列甲板上的椅子？
Alina M Allen,Patrick S Kamath
Alina M Allen
Phase 1 randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction-associated steatohepatitis [0.03%]
针对HSD17B13的RNA干扰疗法治疗代谢功能障碍相关steatohepatitis I期随机双盲研究
Arun J Sanyal,Jorg Taubel,Prajakta Badri et al.
Arun J Sanyal et al.
Background & aims: Genome-wide association studies have identified loss-of-function variants in the hydroxysteroid 17-beta dehydrogenase 13 gene (HSD17B13) associated with reduced risk of chronic liver disease. In this Ph...