GRINA alleviates hepatic ischemia‒reperfusion injury-induced apoptosis and ER-phagy by enhancing HRD1-mediated ATF6 ubiquitination [0.03%]
GRINA通过增强HRD1介导的ATF6泛素化来缓解肝缺血再灌注损伤诱导的细胞凋亡和内质网自噬
Hongjun Yu,Chaoqun Wang,Baolin Qian et al.
Hongjun Yu et al.
Background & aims: Hepatic ischemia‒reperfusion injury (HIRI) is a critical complication of liver surgery and transplantation that contributes significantly to severe organ failure. GRINA, a calcium-regulating endoplasmi...
Hepatocellular CMPK2 promotes the development of metabolic dysfunction-associated steatohepatitis [0.03%]
肝细胞CMPK2促进代谢紊乱相关脂肪性肝炎的发展
Sitong Zhu,Lei Liao,Yi Zhong et al.
Sitong Zhu et al.
Background & aims: Metabolic dysfunction-associated steatohepatitis (MASH), a progressive subtype of metabolic dysfunction-associated steatotic liver disease (MASLD), has limited pharmacological treatment options. Therefo...
Contrast-enhanced ultrasound-based AI model for multi-classification of focal liver lesions [0.03%]
基于CEUS的AI模型用于肝占位性病变多分类诊断价值研究
Wenzhen Ding,Yaqing Meng,Jun Ma et al.
Wenzhen Ding et al.
Background & aims: Accurate multi-classification is the prerequisite for reasonable management of focal liver lesions (FLLs). Ultrasound is the common image examination, but lacks accuracy. Contrast enhanced ultrasound (C...
Leveraging normothermic liver machine perfusion as a platform for oncologic assessment in cirrhotic livers [0.03%]
利用正常体温的肝脏机器灌注作为评估肝硬化肝脏肿瘤学特征的平台技术
Felix J Krendl,Benno Cardini,Heinz Zoller et al.
Felix J Krendl et al.
From the Editor's Desk. [0.03%]
编者来信
Philip N Newsome,Frank Tacke,Heiner Wedemeyer et al.
Philip N Newsome et al.
Genomic and transcriptomic signatures of sequential carcinogenesis from papillary neoplasm to biliary tract cancer [0.03%]
从乳头状肿瘤到胆道癌的顺序致癌过程中的基因组和转录组标志物分析
Taek Chung,Seungho Oh,Jeongsoo Won et al.
Taek Chung et al.
Background & aims: Papillary neoplasms of the biliary tree, including intraductal papillary neoplasms (IPN) and intracholecystic papillary neoplasms (ICPN), are recognized as precancerous lesions. However, the genetic cha...
On the need for an adult-to-adult liver graft split policy-An appraisal [0.03%]
关于制定成人之间分享肝脏移植供体的政策——评述
Xavier Muller,Guillaume Rossignol,Corinne Antoine et al.
Xavier Muller et al.
Modeling the Health and Economic Impact of Pharmacologic Therapies for MASLD in the United States [0.03%]
在美国建立药物治疗MASLD的健康和经济影响模型
Carolyn Wallace,Ivane Gamkrelidze,Chris Estes et al.
Carolyn Wallace et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common condition leading to chronic liver disease which generates substantial health care costs. Our aim was to model the impact o...