European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu;European Association for the Study of the Liver
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu;European Association for the Study of the Liver
Acute-on-chronic liver failure (ACLF), which was described relatively recently (2013), is a severe form of acutely decompensated cirrhosis characterised by the existence of organ system failure(s) and a high risk of short-term mortality. AC...
Practice Guideline
Journal of hepatology. 2023 Aug;79(2):461-491. DOI:10.1016/j.jhep.2023.04.021 2023
A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease [0.03%]
评价efinopegdutide治疗非酒精性脂肪性肝病疗效和安全性的Ⅱa期阳性药物对照研究
Manuel Romero-Gómez,Eric Lawitz,R Ravi Shankar et al.
Manuel Romero-Gómez et al.
Background & aims: This study assessed the effects of the glucagon-like peptide-1 (GLP-1)/glucagon receptor co-agonist efinopegdutide relative to the selective GLP-1 receptor agonist semaglutide on liver fat content (LFC)...
Clinical Trial
Journal of hepatology. 2023 Oct;79(4):888-897. DOI:10.1016/j.jhep.2023.05.013 2023
A global research priority agenda to advance public health responses to fatty liver disease [0.03%]
全球研究重点议程推动脂肪肝疾病公共卫生应对措施的发展
Jeffrey V Lazarus,Henry E Mark,Alina M Allen et al.
Jeffrey V Lazarus et al.
Background & aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are p...
GARP on hepatic stellate cells is essential for the development of liver fibrosis [0.03%]
GARP对肝星状细胞发育及肝纤维化的影响
Xiaolong Zhang,Pankaj Sharma,Patrick Maschmeyer et al.
Xiaolong Zhang et al.
Background & aims: Glycoprotein A repetitions predominant (GARP) is a membrane protein that functions as a latent TGF-β docking molecule. While the immune regulatory properties of GARP on blood cells have been studied, t...
Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease [0.03%]
导管样反应相关中性粒细胞在慢性肝病时促进胆道上皮增殖
Silvia Ariño,Beatriz Aguilar-Bravo,Mar Coll et al.
Silvia Ariño et al.
Background & aims: Ductular reaction expansion is associated with poor prognosis in patients with advanced liver disease. However, the mechanisms promoting biliary cell proliferation are largely unknown. Here, we identify...
Liver disease is a significant risk factor for cardiovascular outcomes - A UK Biobank study [0.03%]
肝病是心血管预后的重要危险因素——英国生物银行研究结果显示
Adriana Roca-Fernandez,Rajarshi Banerjee,Helena Thomaides-Brears et al.
Adriana Roca-Fernandez et al.
Background & aims: Chronic liver disease (CLD) is associated with increased cardiovascular disease (CVD) risk. We investigated whether early signs of liver disease (measured by iron-corrected T1-mapping [cT1]) were associ...
Evaluation and comparison of risk-based and universal prenatal HCV screening programs in Alberta, Canada [0.03%]
加拿大艾伯塔省基于风险和普遍产前HCV筛查项目的评估与比较
L Alexa Thompson,Sabrina S Plitt,Karen Doucette et al.
L Alexa Thompson et al.
Background & aims: Canadian clinical practice guidelines currently recommend risk-based screening for HCV in pregnant individuals. However, no provinces or territories have ever compared the effectiveness of risk-based vs...
Eleonora De Martin,Astrid Laurent-Bellue,Émilie Routier et al.
Eleonora De Martin et al.
From the Editor's Desk. [0.03%]
编者按
Patrizia Burra,Frank Tacke,Vlad Ratziu et al.
Patrizia Burra et al.
Daniel Shouval,Jay H Hoofnagle,Michael Trauner
Daniel Shouval