Nerve Fibres in Psoriatic Skin and Their Relation to Vasculature and Clinical Parameters [0.03%]
银屑病皮肤中的神经纤维及其与血管和临床参数的关系
Meagan Doppegieter,Nick van der Beek,Maurice C G Aalders et al.
Meagan Doppegieter et al.
Emerging evidence supports the neurogenic origin of psoriasis, yet the morphology and distribution of nerve fibres in psoriatic skin remain poorly characterised due to methodological inconsistencies and limited 3D data. The aim of this stud...
The Role of ROS-Mediated Mitochondrial Dysfunction in the Development of Malignant Melanoma [0.03%]
活性氧介导的线粒体功能障碍在恶性黑色素瘤发生中的作用
Lei Li,Zhiwei Zeng,Tengxiao Ma et al.
Lei Li et al.
Reactive oxygen species (ROS) are critical to cellular metabolism, signal transduction and apoptosis. Recent studies have revealed the dual role of ROS in malignant melanoma pathogenesis and progression, where they can both promote tumour p...
Orismilast, a Potent and Selective PDE4B/D Inhibitor, Reduces Protein Levels of Key Disease Driving Cytokines in the Skin of Patients With Plaque Psoriasis [0.03%]
一种有效的PDE4B/D抑制剂Orismilast可降低 plaque psoriasis患者皮肤中关键致病细胞因子的蛋白水平
Richard B Warren,Anne Weiss,Jakob Felding et al.
Richard B Warren et al.
Minimally invasive sampling of the skin using tape strips for conducting biomarker research is a growing research area in medical dermatology. The goal of this study was to utilise tape strip sampling to investigate changes in protein skin ...
Randomized Controlled Trial
Experimental dermatology. 2025 Sep;34(9):e70153. DOI:10.1111/exd.70153 2025
IL-13 From Murine Epidermal γδ T Cells Promotes Wound Healing by Inducing Arginase-1-Positive Hypodermal Macrophages in the Early Inflammatory Phase [0.03%]
小鼠表皮γδT细胞源性IL-13通过诱导早起炎症期肥大细胞向Arginase-1阳性细胞分化促进伤口愈合
Atsuko Ibusuki,Kazuhiro Kawai,Akiko Ito et al.
Atsuko Ibusuki et al.
Murine epidermal γδ T cells, known as dendritic epidermal T cells (DETCs), play critical roles in cutaneous wound healing by secreting chemokines, cytokines and growth factors. Although DETCs predominantly produce IL-13 early after activa...
Rice Bran Extract Alleviates Inflammation and Promotes Wound Healing in Radiation Dermatitis [0.03%]
辐照皮炎小鼠模型中米糠提取物改善皮肤炎症及促进伤口愈合的研究
Chen-Hsiang Kuan,Takatori Hideki,Chun-Ho Wu et al.
Chen-Hsiang Kuan et al.
Radiation dermatitis is a common side effect of radiotherapy, affecting up to 95% of cancer patients receiving radiation therapy and often leading to skin damage, inflammation, and ulceration. The pathogenesis of radiation dermatitis involv...
Visible Light-Induced Pigmentation: Improved In Vivo Methodology for Measuring Efficacy of 30 Products in 9 Randomised Controlled Trials and Correlation With In Vitro Assessment [0.03%]
基于体内体外评估的30种美白产品随机对照实验中的临床功效评测及与体外测试的相关性研究
Pascale Renoux,Hussein Jouni,Clément Laloux et al.
Pascale Renoux et al.
As hyperpigmentation can worsen with exposure to ultraviolet (UV) and visible light (VL), sunscreens with well-balanced UVB/UVA protection and VL-blocking pigments are recommended. Assessing efficiency against VL-induced pigmentation is the...
Randomized Controlled Trial
Experimental dermatology. 2025 Sep;34(9):e70167. DOI:10.1111/exd.70167 2025
The Association Between Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio With Psoriasis: A Cross-Sectional Survey and Genetic Approach [0.03%]
非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与银屑病的关联：横断面调查和遗传学方法研究
Hao Dai,Zihao Li,Jiahui Hu et al.
Hao Dai et al.
This study utilised NHANES data from 2003 to 2006 and 2009 to 2014 to explore the association between the non-high-density lipoprotein to high-density lipoprotein cholesterol ratio (NHHR) and psoriasis. A total of 15 437 U.S. adults were an...
The Role of Cutaneous B-Cells in Hidradenitis Suppurativa: From Preclinical Evidence to Novel Targeted Therapies [0.03%]
汗腺炎中皮肤B细胞的作用：从临床前证据到新型靶向治疗
Maurizio Romagnuolo,Laura Calabrese,Martina D&#x;Onghia et al.
Maurizio Romagnuolo et al.
Hidradenitis Suppurativa (HS) is a chronic autoinflammatory skin disease of the terminal hair follicle, whose pathogenesis is complex and multifactorial. Alongside a predisposing genetic background, environmental/epigenetic factors, alterat...
Targeting Melanin Heterogeneity in Metastatic Melanoma: A Dual-Tumour Mouse Melanoma Model [0.03%]
针对黑色素瘤转移的小鼠双肿瘤异种移植模型研究黑色素的异质性
Marine Delmas,Benjamin Chaussin,Nathan Harismendy et al.
Marine Delmas et al.
The combination of melanin-targeted radionuclide therapy (TRT) and immunotherapy offers potential in overcoming melanoma resistance to conventional therapies. Studying the potential abscopal effect induced by TRT is essential to evaluate su...
Targeting Melanoma Cell Adhesion Molecule as a Novel Therapeutic Approach for Acral Melanoma [0.03%]
靶向粘膜黑色素瘤的新治疗策略——黏附分子ACM抗体药物偶联物的构建及作用机制研究
Yuka Tanaka,Takamichi Ito,Kiichiro Nishio et al.
Yuka Tanaka et al.
Acral melanoma (AM) is a rare subtype of cutaneous melanoma mainly found in acral locations. The treatment of advanced AM remains challenging due to its rarity and the distinct features of this subtype compared with the other common types o...