Clinical characteristics of patients with difficult-to-treat ulcerative colitis: a nested case-control study using a Japanese claims database [0.03%]
难治性溃疡性结肠炎患者的临床特征：日本理赔数据库中的一项病例对照研究
Katsuyoshi Matsuoka,Ataru Igarashi,Noriko Sato et al.
Katsuyoshi Matsuoka et al.
Background/aims: Despite the advent of advanced therapies, cases of so-called "difficult-to-treat" (D2T) ulcerative colitis (UC) persist. This study aims to clarify the epidemiological and clinical characteristics of pati...
Efficacy and safety of etrasimod in Japanese patients with ulcerative colitis: results from a phase 2 dose-ranging study [0.03%]
艾替洛尔治疗日本溃疡性结肠炎患者的有效性和安全性：一项Ⅱ期剂量范围研究结果
Ken Takeuchi,Hiroshi Nakase,Tadakazu Hisamatsu et al.
Ken Takeuchi et al.
Background/aims: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). However, its efficacy, safety, and t...
Inflammatory bowel disease in a young female patient with a novel de novo TRAF3 frameshift variant responsive to ustekinumab: a case report [0.03%]
年轻女性溃疡性结肠炎患者新发TRAF3移码变异病例的乌司奴单抗治疗响应研究报告
Ichiro Takeuchi,Kosuke Taniguchi,Katsuhiro Arai et al.
Ichiro Takeuchi et al.
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an anti-inflammatory molecule that negatively regulates the non-canonical nuclear factor-κB pathway. Although TRAF3 haploinsufficiency (TRAF3 HI) can influence innate and adapti...
Case Reports
Intestinal research. 2025 Apr 4. DOI:10.5217/ir.2024.00190 2025
Restoration of colonic barrier function by tofacitinib in experimental colitis: anti-inflammatory effects and decreased expression of claudins-2 and claudin-15 [0.03%]
托法替尼在实验性结肠炎中恢复结肠屏障功能：抗炎作用以及claudins-2和claudin-15表达减少
Humberto Barbosa da Costa Filho,Gerardo Autran Cavalcante Araújo,Thiago Meneses Araújo Leite Sales et al.
Humberto Barbosa da Costa Filho et al.
Background/aims: Inflammatory bowel disease can be triggered by disturbances in intestinal mucosal integrity, leading to bacterial transmigration. The treatment of inflammatory bowel diseases must not only aim to reduce i...
Comparative short-term efficacy of upadacitinib versus tofacitinib for ulcerative colitis: a 24-week real-world study in Japan [0.03%]
溃疡性结肠炎患者中upadacitinib与tofacitinib的短期疗效对比：来自日本的24周真实世界研究
Akiko Tamura,Hiromichi Shimizu,Toshimitsu Fujii et al.
Akiko Tamura et al.
Background/aims: Tofacitinib and upadacitinib are small-molecule compounds that inhibit the Janus kinase pathway for the treatment of refractory ulcerative colitis. Only a few reports have compared the efficacy and safety...
Characteristics and long-term outcomes of children with perianal Crohn's disease [0.03%]
肛周克罗恩病儿童的特征和长期预后
Ching-Chun Lin,Ichiro Takeuchi,Hirotaka Shimizu et al.
Ching-Chun Lin et al.
Background/aims: The incidence of perianal lesions (PL) in children with Crohn's disease (CD) is higher in East Asia than in Western countries. Early intervention for PL is essential to prevent sphincter dysfunction and o...
Process of empowerment in mothers of children with very-early-onset inflammatory bowel disease: a qualitative study [0.03%]
极早期发作炎症性肠病患儿的母亲赋权过程的质性研究
Mikako Yokoo,Satomi Nomura,Satoe Fukui et al.
Mikako Yokoo et al.
Background/aims: Mothers of children with very-early-onset inflammatory bowel disease (VEO-IBD) face unique challenges; however, these challenges and their consequences have not been well described. This study clarified t...
Newly designed flared-end covered versus uncovered self-expandable metallic stents for palliation of malignant colorectal obstruction: a randomized, prospective study [0.03%]
新型喇叭口覆盖与非覆盖金属支架治疗恶性结肠梗阻的随机研究
Soo Jung Park,Yehyun Park,Hyun Jung Lee et al.
Soo Jung Park et al.
Background/aims: Self-expandable metallic stents (SEMSs) are widely used as palliative or bridge to surgery treatments in patients with malignant colorectal obstruction (MCO). Stent occlusion is more common with uncovered...
Himani Pandey,Daryl W T Tang,Sunny H Wong et al.
Himani Pandey et al.
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a nonspecific chronic inflammation of the gastrointestinal tract. Despite recent advances in therapeutics and newer management strategies, IBD large...
The impact of COVID-19 on clinical practices of colorectal cancer in South Korea [0.03%]
COVID-19对韩国结直肠癌临床实践的影响
Kwang Woo Kim,Hyoun Woo Kang
Kwang Woo Kim