Integrative bioinformatics and experimental validation identify IL1A as a novel therapeutic target for diabetic wound healing [0.03%]
整合生物信息学和实验验证鉴定出IL1A是糖尿病伤口愈合的新型治疗靶点
Guowang Zhang,Tao An,Shuai Dai et al.
Guowang Zhang et al.
Diabetic foot ulcers (DFUs) represent a severe complication of diabetes mellitus, characterized by impaired wound healing and persistent inflammation. Despite advances in understanding the molecular mechanisms underlying DFU pathogenesis, e...
Development and validation of an explainable machine learning model using routine laboratory biomarkers for identifying prevalent MASLD: Evidence from two observational studies [0.03%]
基于两项观察性研究的常规实验室生物标志物识别现患MASLD的可解释机器学习模型的开发与验证
Jialin Wu,Wenting Wei,Terry Cheuk-Fung Yip et al.
Jialin Wu et al.
Although many predictive models for metabolic dysfunction-associated steatotic liver disease (MASLD) have been developed, their performance remains suboptimal. We aimed to develop an interpretable machine learning (ML)-based plasma biomarke...
Integrating Network Pharmacology and Experimental Validation to Elucidate the Role of Huaier in Attenuating Liver Fibrosis via the AKT Signalling Pathway [0.03%]
基于网络药理学和实验验证的槐耳抗肝纤维化的活性成分及作用机制研究
Jiachun Ding,Jiaqiang Ren,Fan Chen et al.
Jiachun Ding et al.
Liver fibrosis, a critical pathological precursor of cirrhosis and hepatocellular carcinoma, represents a significant unmet global health challenge because of the lack of effective targeted therapies that can reverse established fibrotic sc...
Pre-transplant JAK-inhibition improves post-transplant outcome in myelofibrosis [0.03%]
移植前使用JAK抑制剂改善移植后原发性骨髓纤维化患者的预后
Patrycja Zielińska,Agata Wieczorkiewicz-Kabut,Adrianna Spałek et al.
Patrycja Zielińska et al.
Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only curative approach in myelofibrosis (MF). Janus-Associated Kinase inhibitors (JAKi) have changed the treatment paradigm of MF patients, becoming a therapeutic mai...
Ultra-Low BCR::ABL1 positivity by digital PCR does not improve post-transplant risk stratification beyond real-time PCR in Ph+ acute lymphoblastic leukemia post-transplant [0.03%]
移植后超低水平的BCR-ABL1阳性结果并不能通过数字PCR改善Ph+急性淋巴细胞白血病实时定量PCR的风险分层
Ya Luo,Wen-Min Chen,Xiao-Su Zhao et al.
Ya Luo et al.
Background: Post-transplant relapse remains a major clinical challenge in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL). Real-time quantitative PCR (RQ-PCR) for BCR::ABL1 is the current standard...
Optimized interpretation of p53 immunohistochemistry for prediction of TP53 mutations and patient survival in DLBCL [0.03%]
优化解读免疫组化p53以预测DLBCL患者TP53突变及预后
Jing Ruan,Yupeng Wang,Congwei Jia et al.
Jing Ruan et al.
The prognostic value of p53 immunohistochemical (IHC) staining in diffuse large B cell lymphoma (DLBCL) remains controversial. We retrospectively included 149 patients who were diagnosed with and treated for DLBCL at Peking Union Medical Co...
Natural phenolic compounds as modulators of radiation response in hepatocellular carcinoma [0.03%]
天然苯酚化合物作为调节肝癌辐射反应的药物
Amirhossein Imani,Fatemeh B Rassouli
Amirhossein Imani
Radiotherapy remains a cornerstone in the treatment of hepatocellular carcinoma (HCC), yet its clinical efficacy is constrained by the intrinsic radioresistance of liver tumors and the dose-limiting toxicity to surrounding healthy tissue. N...
A prospective, open, single-arm clinical trial of fludarabine- cyclophosphamide-porcine anti-lymphocyte globulin conditioning combined with matched sibling donor hematopoietic stem cell transplantation in the treatment of severe aplastic anemia [0.03%]
佛达拉滨-环磷酰胺-猪抗淋巴细胞球蛋白预处理结合全同胞造血干细胞移植治疗重型再生障碍性贫血的临床研究
Xiaoyan Zhao,Ziwei Xu,Yan Sun et al.
Xiaoyan Zhao et al.
Hematopoietic stem cell transplantation (HSCT) remains an effective treatment for severe aplastic anemia (SAA), but the optimal conditioning regimen has yet to be established. This study aimed to evaluate the safety and efficacy of a condit...
Association of the RDW-to-albumin ratio with MAFLD and hepatic fibrosis in the U.S. population: a national cross-sectional study [0.03%]
RDW与血清白蛋白比率与美国人群的MAFLD和肝纤维化的关联性：一项全国横断面研究
Xueqin He,Qingfeng Zeng,Weibin Liu et al.
Xueqin He et al.
Systemic inflammation plays a key role in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). The red blood cell distribution width (RDW) and serum albumin levels are well-recognized biomarkers reflecting infla...
HSP90AA1 inhibits the Jun/Fos pathway to rescue hepatocytes from cuproptosis during ischemia-reperfusion injury [0.03%]
HSP90AA1通过抑制Jun/Fos途径在缺血再灌注损伤过程中拯救肝细胞免于铜依赖性细胞死亡（cuproptosis）
Songling Xu,Yang Liu,Yingying Han et al.
Songling Xu et al.
Hepatic ischemia-reperfusion injury (HIRI), a frequent complication in procedures like hepatic lobectomy and organ transplantation, remains a significant clinical challenge despite advances in protective strategies. Cuproptosis, a copper-de...