B3GNT7 preserves intestinal barrier integrity: a key defense mechanism against acute pancreatitis progression [0.03%]
B3GNT7保护肠屏障的完整性：急性胰腺炎进展的关键防御机制
Jia Hu,Yang Fu,Zehua Huang et al.
Jia Hu et al.
Mucin-2 (MUC2) plays a crucial role in maintaining intestinal homeostasis during acute pancreatitis (AP). We aimed to investigate the role of B3GNT7 (β-1,3-N-acetylglucosamine transferase) in the O-glycosylation of MUC2 in AP. We used two ...
Outcomes of allogeneic hematopoietic stem cell transplantation in patients with blast phase myelofibrosis: molecular signature and intensive chemotherapy matter [0.03%]
同种异基因造血干细胞移植治疗急性变性骨髓纤维化患者的结局：分子特征和强化化疗的影响
Francesca Valsecchi,Maria Chiara Finazzi,Silvia Salmoiraghi et al.
Francesca Valsecchi et al.
Patients with blast-phase (BP) myeloproliferative neoplasms have dismal outcomes, but allogeneic hematopoietic stem cell transplantation (alloHSCT) may offer a potential cure. However, the optimal pre-transplant blast-reduction therapy rema...
The diagnostic and short-term prognostic significance of miR-183-5p in pulmonary embolism and its regulation of disease progression through PDCD4 [0.03%]
miR-183-5p在肺栓塞中的诊断及短期预后意义及其通过PDCD4调控疾病进展的作用
Shu Wang,Qian Wu,Wenfei Xu et al.
Shu Wang et al.
The incidence of pulmonary thromboembolism (PTE) has increased year on year, with high rates of misdiagnosis and recurrence, as well as significant heterogeneity in prognosis. This study investigated the clinical value of miR-183-5p in PTE,...
Acute myeloid leukemia in HIV-positive patients: biological crossroads and therapeutic Hurdles [0.03%]
HIV阳性患者中的急性髓系白血病：生物学交叉点与治疗障碍
Mohamed J Saadh,Faris Anad Muhammad,Rafid Jihad Albadr et al.
Mohamed J Saadh et al.
Acute myeloid leukemia (AML), characterized by aberrant hematopoiesis and aggressive clinical behavior, remains a therapeutic challenge even with advances in targeted therapies and hematopoietic stem cell transplantation. In human immunodef...
CDK9 and hematologic malignancies: pioneering novel therapeutic approaches [0.03%]
CDK9与血液系统恶性肿瘤：开创性治疗新策略
Hanie Raufi,Pouya Zahmatkesh,Sahar Safaei et al.
Hanie Raufi et al.
cyclin-dependent kinase 9 (CDK9) A key regulator of transcriptional elongation influences the transcription of oncogenes and anti-apoptotic proteins. Within the context of the positive transcription elongation factor b (P-TEFb) complex, CDK...
Integrative analysis and experimental validation of dioxin-interacting genes reveal diagnostic and prognostic biomarkers in lung adenocarcinoma [0.03%]
集积分级和实验验证的二恶英互作基因在肺腺癌中的诊断及预后标志物研究
Guofang Yin,Bo Li,Shiming Fan et al.
Guofang Yin et al.
Dioxins are persistent environmental pollutants and key components of the human exposome with established carcinogenic potential. As airborne toxicants, they link environmental pollution to lung adenocarcinoma (LUAD), yet their molecular me...
A review of deep learning-based multimodal data integration of lung cancer [0.03%]
基于深度学习的肺癌多模态数据集成研究进展
Ya Qin,Simin Wang,Dan Wu et al.
Ya Qin et al.
This is a narrative review that provides a perspective on the recent advances in deep learning (DL)-driven multimodal data integration for lung cancer. Lung cancer remains the most prevalent malignancy and the leading cause of cancer-relate...
PSMC2 promotes hepatocellular carcinoma progression through interaction with EGFR [0.03%]
PSMC2通过与EGFR相互作用促进肝癌进展
Yecheng Li,Qunxue Su,Zhenyu Feng et al.
Yecheng Li et al.
Growing evidence highlights the critical involvement of the ubiquitin-proteasome system in cancer development. As an essential component of the 26 S proteasome, Proteasome 26 S Subunit ATPase 2 (PSMC2) has been implicated in various maligna...
Plasma exosome lncRNA panel as a non-invasive biomarker for molecular diagnosis of systemic lupus erythematosus [0.03%]
血浆外泌体长链非编码RNA谱作为系统性红斑狼疮分子诊断的无创生物标志物
Zhi Li,Shujun Wan,Xueqin Li et al.
Zhi Li et al.
Exosome-derived long non-coding RNAs (lncRNAs) have emerged as promising diagnostic biomarkers in various diseases. However, their diagnostic potential in systemic lupus erythematosus (SLE) remains largely unexplored. This study aimed to ch...
Multiple Myeloma in Children and Young Adults: A Systematic Literature Review [0.03%]
儿童及青年人群中的多发性骨髓瘤：系统文献回顾
Georgia Poultsaki,Theodoros P Vassilakopoulos,Evangelos Terpos et al.
Georgia Poultsaki et al.
Multiple myeloma (MM) is extremely rare in pediatric and young adult populations, and its clinical characteristics, therapeutic strategies, and outcomes remain poorly defined. This systematic review consolidates all published cases of MM in...