Venetoclax, azacitidine, and chidamide in combination with cytarabine, aclarubicin, and G-CSF as induction chemotherapy for myelodysplasia-related acute myeloid leukemia [0.03%]
维奈克拉、阿扎胞苷和氯達明联合阿糖胞苷、表柔比星和G-CSF用于骨髓增生异常综合征相关急性髓系白血病的诱导化疗
Lei Lv,Jingjing Yang,Qingyang Liu et al.
Lei Lv et al.
Myelodysplasia-related acute myeloid leukemia (AML-MR) exhibits poor outcomes with intensive chemotherapy. This retrospective study was conducted to evaluate the clinical efficacy and safety of the Venetoclax, Azacitidine, and Chidamide in ...
Jiaojiao Han,Shanshan Li,Pengyu Xie et al.
Jiaojiao Han et al.
This study aimed to identify the clinical characteristics of systemic lupus erythematosus (SLE) patients with complicated with lupus mesenteric vasculitis (LMV), and to determine the impacts of the first-visit department, the number and dur...
Analysis of the clinical characteristics of warfarin-associated purple toe syndrome [0.03%]
华法林相关性紫趾综合征的临床分析
Can Shi,Siyi Zhang,Songhua Chen et al.
Can Shi et al.
Purple toe syndrome (PTS) represents a critical yet underrecognized complication of warfarin therapy. To characterize this condition, we conducted a retrospective analysis of all reported warfarin-associated PTS cases through April 30, 2025...
Circ-MAP4K3 promotes papillary thyroid cancer progression by sponging miR-758-3p to enhance RRM2 expression [0.03%]
环状RNA Circ-MAP4K3通过海绵吸附miR-758-3p来增强RRM2表达从而促进乳头状甲状腺癌的进展
Yi Dong,Jiangnan Dong,Jun Li et al.
Yi Dong et al.
Papillary thyroid cancer (PTC) is an endocrine malignancy with a high incidence. PTC metastasizes more frequently in children and teenagers, although survival of these patients is usually considered excellent. Still, research on regulatory ...
Adipose-derived mesenchymal stem cell-derived extracellular vesicles reduce glycolysis and polarize macrophages toward M2 phenotype in sepsis-associated acute kidney injury via the miR-574-5p/GLUT1 axis [0.03%]
脂肪源性间充质干细胞衍生的细胞外囊泡通过miR-574-5p/GLUT1轴降低糖酵解并使脓毒症相关急性肾损伤向M2型表型极化
Jinbo Zhang,Jinling Li,Xiaohong Jin et al.
Jinbo Zhang et al.
Extracellular vesicles (EVs) from adipose-derived mesenchymal stem cells (ADSCs) may exert a therapeutic benefit in sepsis-associated organ dysfunction by delivering cargos to target cells. The aims of this study were to explore the therape...
Morpho-functional plasticity of tumour-associated macrophages: linking cell shape, ultrastructure, and immune regulation in cancer [0.03%]
肿瘤相关巨噬细胞的形态功能可塑性：连接癌细胞形态、超结构和免疫调节
Keerthana Suresh Kizhakkanoodan,Vidhula Jessica Inigo,Sindhura Lakshmi Koulmane Laxminarayana et al.
Keerthana Suresh Kizhakkanoodan et al.
Macrophages are highly adaptable immune cells that play dual roles in the tumor microenvironment (TME), either promoting or restraining tumor progression. Their polarization into M1 and M2 tumor-associated macrophage (TAM) phenotypes is cla...
Integrated multi-omics analysis: exploring the molecular regulatory mechanisms of HIV infection and identifying the key gene WFDC2 [0.03%]
整合多组学分析：探究HIV感染的分子调控机制及关键基因WFDC2的识别
Bingqing Yan,Tiantian Jiang,Yayun Wu et al.
Bingqing Yan et al.
Although substantial progress has been made in the treatment of HIV infection, the regulatory mechanisms linking genetic variation, transcriptomic alterations, immune-cell changes, and post-transcriptional control remain poorly defined. A s...
Exosomal integrin αvβ3 derived from colorectal cancer promotes the liver pre-metastatic niche formation by inducing cancer-associated fibroblasts activation [0.03%]
结肠癌来源的外泌体整合素αvβ3通过诱导癌症相关成纤维细胞活化促进肝前期转移灶形成
Jing Yu,Jiangning Xiang,Lin Yao et al.
Jing Yu et al.
The formation of the liver pre-metastatic niche (PMN) is a critical factor in the development of colorectal cancer liver metastasis (CRLM), so understanding the mechanism of the liver PMN is crucial for the prevention and treatment of CRLM....
Man Li,Xiao Wang,Pengen Li et al.
Man Li et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive gastrointestinal cancers, with over 90% of cases harboring KRAS gene mutations. These mutations not only serve as key drivers of tumorigenesis but also reshape the tumor ...
Exosomal lncRNAs as molecular switches driving macrophage-tumor co-evolution in breast cancer [0.03%]
乳腺癌中作为分子开关驱动巨噬细胞-肿瘤共生的外泌体长链非编码RNA
Mahsa Javadian,Tahereh Zeinali,Morteza Rajabi et al.
Mahsa Javadian et al.
Breast cancer progression is increasingly recognized as a dynamic process shaped by reciprocal communication between malignant cells and the tumor microenvironment (TME). Among immune-cell populations, tumor-associated macrophages (TAMs) ar...