Research progress on the regulation of mesothelioma driven by deubiquitinating enzyme BAP1 [0.03%]
泛素特异性蛋白酶BAP1调控间皮瘤的研究进展
Wan-Ting Xuan,Yao Dong,Si-Yuan Ma et al.
Wan-Ting Xuan et al.
Mesothelioma is a highly aggressive malignancy that develops through the combined influence of several factors, including environmental exposure, genetic susceptibility, immune status, and aberrant activation or dysregulation of signaling p...
Dietary fatty acids intake and the risk of advanced cardiovascular-kidney-metabolic syndrome: evidence from NHANES 1999-2018 [0.03%]
膳食脂肪酸摄入与心血管-肾脏-代谢综合征发病风险的相关性：来自1999-2018年NHANES调查的证据
Qiuhui Wang,Fengming Liang,Hongyang Xu et al.
Qiuhui Wang et al.
Cardiovascular-Kidney-Metabolic syndrome (CKM) is a multisystem disorder involving cardiovascular, renal, and metabolic dysfunction, with advanced stages (3-4) linked to high morbidity and mortality. Dietary fatty acids (FA) play critical r...
Ferroptosis-associated immune modulation enhances temozolomide efficacy in experimental glioblastoma: potential implications for T-cell infiltration and tumour microenvironment dynamics [0.03%]
与铁死亡相关的免疫调节可增强替莫唑胺对实验性胶质母细胞瘤的疗效：T细胞浸润和肿瘤微环境动态变化的潜在影响
Shaik Rahaman,Roli Kushwaha,Divya Vohora et al.
Shaik Rahaman et al.
Glioblastoma multiforme (GBM) remains a lethal and aggressive malignancy with limited response to standard therapies. This study hypothesized that artesunate, a ferroptosis inducer, enhances the cytotoxic and immunomodulatory efficacy of st...
Exploring the mechanism by which triphenyl phosphate promotes malignant phenotypes in bladder and kidney cancer through MMP9 based on bioinformatics analysis and experimental validation [0.03%]
基于生物信息学分析和实验验证探索三苯基磷酸通过MMP9促进膀胱癌和肾癌恶性表型的机制
Hao Wang,Hongquan Liu,Qian Li et al.
Hao Wang et al.
Background Bladder and kidney cancer burden rises globally, with environmental toxicants driving their progression. Methods We integrated global epidemiological analysis, single-cell transcriptomics, cell-cell communication analysis, epithe...
Clonal dynamic changes during the progression of myelodysplastic neoplasms to secondary acute myeloid leukemia: a paired-sample comparison [0.03%]
骨髓增生异常肿瘤向继发性急性髓系白血病进展过程中的克隆动态变化：配对样本比较研究
Che-Wei Ou,Hsiao-Wen Kao,Tung-Liang Lin et al.
Che-Wei Ou et al.
Patients with myelodysplastic neoplasms (MDS) have a risk of secondary acute myeloid leukemia (sAML) transformation, but previous studies on the paired samples at both MDS and sAML were very rare. This study aimed to investigate the genetic...
Silibinin promotes hepatocyte proliferation through PINK1/Parkin-mediated mitophagy to alleviate acetaminophen-induced liver injury [0.03%]
丝利茋通过PINK1/Parkin介导的线粒体自噬促进肝细胞增殖以缓解对乙酰氨基酚致肝损伤
Fengming Xu,Mohamed Albadry,Olaf Dirsch et al.
Fengming Xu et al.
Acetaminophen (APAP) intoxication is a common cause of liver injury. Silibinin has demonstrated potent hepatoprotective properties. However, its underlying mechanisms in APAP-induced liver injury (AILI) remain unclear. Autophagy is a critic...
Serum GRP78 as a potential biomarker for early liver injury and active fibrogenesis in alcohol-associated liver disease [0.03%]
血清GRP78可作为酒精性肝病早期肝损伤及活性纤维增生潜在标志物
Yongping Liu,Yaojie Shen,Yuxia Yu et al.
Yongping Liu et al.
Alcohol-associated liver disease(ALD) is an important cause of liver-related lesions and death, mainly caused by long-term or excessive alcohol consumption.Reactive oxygen species (ROS) produced during alcohol metabolism induce an oxidative...
Beyond polarization: a receptor-centered framework for macrophage function and therapy in skin diseases [0.03%]
超越极化：皮肤疾病中巨噬细胞功能和治疗的受体中心框架
Yirou Zhu,Huiyi Yao,Wenzhong Xiang
Yirou Zhu
Macrophages are key regulators of cutaneous immunity, but the traditional M1/M2 polarization model cannot fully explain their functional diversity across skin diseases. In this narrative review, we use selected skin diseases to discuss a re...
UBA2: the gatekeeper of the sumoylation pathway and its multifaceted roles in human diseases and therapeutic prospects [0.03%]
UBA2：泛素类似物（SUMO）通路的守门者及其在人类疾病和治疗中的多种作用
Yi Liu,Qi Deng,Yang Qu et al.
Yi Liu et al.
Ubiquitin-like modifier-activating enzyme 2 (UBA2), the core catalytic subunit of the ubiquitin-activating enzyme (E1) for the small ubiquitin-like modifier (SUMO)ylation pathway, is the "gatekeeper" determining cellular SUMOylation levels....
Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics [0.03%]
克隆转化：利用单细胞和空间多组学技术解析MPN演化
Muhammad Shahid Iqbal,Abdullah K Alahmari,Mohd Faiyaz Khan et al.
Muhammad Shahid Iqbal et al.
Myeloproliferative neoplasms (MPNs) present a fundamental paradox: despite sharing a small set of canonical driver mutations in JAK2, CALR, or MPL, patients exhibit striking heterogeneity in disease latency, clinical presentation, and evolu...