Eosinophilic vacuolated tumor of the kidney can have distant metastasis: a histo-molecular case study [0.03%]
肾脏嗜酸性泡沫状肿瘤可发生远处转移：一项病理-分子病例研究
Yang Liu,Luting Zhou,Xianwei Yang et al.
Yang Liu et al.
Eosinophilic vacuolated tumor (EVT) is an emerging renal entity and further studies are required to characterize this neoplasm. EVT is considered generally indolent because metastasis or death from the disease has never been reported. Herei...
Case Reports
Pathologica. 2025 Apr;117(2):162-164. DOI:10.32074/1591-951X-1122 2025
Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusion: report of two cases with different clinical presentation [0.03%]
不同临床表现的髓系/淋巴系肿瘤伴嗜酸性粒细胞增多和酪氨酸激酶基因融合2例报告
Elisabetta Merenda,Katia Paciaroni,Emilia Scalzulli et al.
Elisabetta Merenda et al.
Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (M/LN-eo-TK) such as PDGFRA, PDGFRB, FGFR1, JAK2, FLT3 rearrangement and ETV6::ABL1 fusion include rare and heterogeneous clinical-pathological entities with some...
Case Reports
Pathologica. 2025 Apr;117(2):156-161. DOI:10.32074/1591-951X-975 2025
A tricky nasal polyp [0.03%]
蹊跷的鼻息肉
Federica Filipello,Daniela Finocchiaro,Alessandro Vinciguerra et al.
Federica Filipello et al.
Leishmaniasis is an infectious disease caused by a protozoon of the genus Leishmania. It can manifest as cutaneous, mucosal, localized lymphadenitis forms or it can result as multiorgan involvement. In this article we present the case of a ...
Case Reports
Pathologica. 2025 Apr;117(2):153-155. DOI:10.32074/1591-951X-783 2025
One protocol to rule them all: a pilot study to identify the best fixation and decalcification approach for bone marrow biopsy immunohistochemistry [0.03%]
一种协议通吃所有：骨髓活检免疫组化的最佳固定和去钙方法的试点研究
Michele Paudice,Alessandro Gambella,Simona Pigozzi et al.
Michele Paudice et al.
Objective: Standardization of the pre-analytical phases of bone marrow trephine biopsy (BM) has yet to be achieved. In particular, several fixative and decalcifying reagents with specific benefits and drawbacks are descri...
Biopsy in chronic liver disease: proposal for a shared path between clinicians and pathologists [0.03%]
慢性肝病的活检：临床医生和病理学家之间的共识路径的建议
Andrea Baiocchini,Maria Conti,Daniela Fanni et al.
Andrea Baiocchini et al.
Introduction: Liver biopsy is fundamental for characterizing chronic liver disease. Effective communication between specialists during the diagnostic process is crucial. This project aims to outline a diagnostic path shar...
Head and neck synovial sarcoma in a woman with previous lymphoma and papillary thyroid carcinoma [0.03%]
一名以前患有淋巴瘤和乳头状甲状腺癌的女性出现头部和颈部滑膜肉瘤
Mariano Lombardi,Daniela Lepanto,Eleonora Pisa et al.
Mariano Lombardi et al.
Synovial sarcoma is a rare malignant mesenchymal neoplasm that rarely arises in the head and neck and thyroid lodge. Researchers have documented only few cases in the literature. We present the case of a young woman diagnosed with synovial ...
Case Reports
Pathologica. 2025 Apr;117(2):131-135. DOI:10.32074/1591-951X-1034 2025
KRAS/NRAS variants and copy number alterations prognostically stratify patients with sinonasal melanoma [0.03%]
KRAS/NRAS变异和拷贝数改变可以预后分层鼻腔鼻窦恶性黑色素瘤患者
Laura Libera,Nora Sahnane,Mario Turri-Zanoni et al.
Laura Libera et al.
Sino-nasal mucosal melanoma (SN-MM) is an aggressive and rare form of melanoma arising from mucosal melanocytes with pathogenesis unrelated to sun exposure. Conversely to cutaneous melanoma (CM), the molecular bases underling SN-MM developm...
Evaluation of papillary thryoid carcinoma and its variants: multifocality in thyroid lobectomy and completion thyroidectomy - a single tertiary center retrospective study [0.03%]
评估乳头状甲状腺癌及其变异类型：单中心回顾性研究中的甲状腺叶切除术和完成式甲状腺切除术中的多灶性特征
Carmine Bruno,Pietro Tralongo,Federica Vegni et al.
Carmine Bruno et al.
Aims: The American Thyroid Association (ATA) updated guidelines for the treatment of thyroid cancer, leading to a less aggressive approach depending on clinical-pathological features. As a result, the possibility to perfo...
Silvia Varricchio,Rosaria Cappiello,Francesca Magnoli et al.
Silvia Varricchio et al.
In 2024, the World Health Organization published its 5th edition of tumor classification, which comprises several updates and modifications in the "blue book" focused on head and neck tumors. These changes feature a systematized and expande...
Cell-mediated mucositis of the oral cavity: narrative review on etiology, clinico-pathological aspects and malignant transformation [0.03%]
口腔粘膜的细胞介导型黏膜炎：病因、临床病理及恶性转化综述
Giulia Querzoli,Anna Gabusi,Davide Bartolomeo Gissi et al.
Giulia Querzoli et al.
Cell-mediated mucositis is the expression of a type IV hypersensitivity, in which cytotoxic CD8+ T lymphocytes attack the keratinocytes of the basal layer responsible for activating the immune response. There is sufficient evidence for an i...