Paul Langerhans (1847-1888): perceiving the unknown and describing it [0.03%]
保罗·朗格汉斯(1847-1888)：感知未知并描述它
Carlo Patriarca,Guido Petracco,Giacomo Maria Pini et al.
Carlo Patriarca et al.
Paul Langerhans Jr. described under the microscope single cells and aggregates never seen before; he had broad interests and a non-ordinary biography. He died young from tuberculosis, but continued to study until the end, driven by curiosit...
Mucoepidermoid carcinoma of the thymus: a case report with emphasis on the differential diagnosis [0.03%]
胸腺黏液表皮样癌一例并重视其鉴别诊断
Angelina Pernazza,Gian Marco Andreoli,Luigi Vittori et al.
Angelina Pernazza et al.
Primary thymic mucoepidermoid carcinoma (TMEC) is extremely rare and only a few cases have been reported in the literature. We describe the case of a TMEC in elderly man, with atypical morphological features that could lead potential diagno...
Case Reports
Pathologica. 2025 Dec;117(5):519-522. DOI:10.32074/1591-951X-1271 2025
Expanding the spectrum of AFF2 undifferentiated sarcoma associated to endometriosis: a novel ZDHHC9::AFF2 fusion sarcoma with high-grade features and poor prognosis [0.03%]
与子宫内膜异位症相关的AFF2型未分化肉瘤的临床病理特征及分子遗传学研究：一种新的ZDHHC9::AFF2融合基因型高级别肉瘤伴有预后不良的临床病理及分子遗传学研究
Damiano Arciuolo,Rita Alaggio,Antonio Travaglino et al.
Damiano Arciuolo et al.
The AFF2 gene encodes a protein involved in transcriptional regulation and chromatin remodeling. While primarily associated with Fragile X syndrome, AFF2 fusions have recently been identified in certain malignancies, mostly sinonasal squamo...
Case Reports
Pathologica. 2025 Dec;117(5):513-518. DOI:10.32074/1591-951X-1221 2025
Malignant metastatising solitary fibrous tumor of the ovary with additional dedifferentiation and osteoid deposition: an unusual presentation, with a brief description of a diagnostic alghoritm [0.03%]
卵巢恶性孤立性纤维性肿瘤伴去分化及骨样组织沉积的罕见表现，并简述诊断算法
Livia Maccio,Emma Bragantini,Mattia Barbareschi et al.
Livia Maccio et al.
Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm showing fibroblastic differentiation, initially observed in the pleura, but now currently recognized to develop in any extrapleuric location 1,2. In the female genital tract, SFTs...
Case Reports
Pathologica. 2025 Dec;117(5):508-512. DOI:10.32074/1591-951X-N1180 2025
Harmonization trial of FGFR1-3 testing strategies in cholangiocarcinoma patients: an Italian multicenter experience [0.03%]
意大利多中心肝内胆管癌患者FGFR1-3检测策略的协同试验经验
Francesco Pepe,Gianluca Russo,Claudia Scimone et al.
Francesco Pepe et al.
Aims: Molecular analysis of FGFR2 aberrant transcripts became crucial for clinical stratification of intrahepatic cholangiocarcinoma (iCCA) patients. Several strategies, including fluorescent in situ hybridization (FISH) ...
Multicenter Study
Pathologica. 2025 Dec;117(5):496-507. DOI:10.32074/1591-951X-1317 2025
MTAP in small biopsy samples of pancreatic lesions: a potential diagnostic biomarker. Immunohistochemical, fluorescence in situ hybridization and molecular analysis [0.03%]
胰腺病变小活检标本中MTAP的免疫组化、荧光原位杂交和分子分析：潜在诊断生物标志物
Stefano Lucà,Cecilia Salzillo,Valeria Masola et al.
Stefano Lucà et al.
Background: Most pancreatic ductal adenocarcinoma (PDAC) are diagnosed with fine needle aspiration biopsies (FNAB). Some benign mimickers exist, and the differential diagnosis can be challenging. Immunohistochemistry (IHC...
The contribution of methylation profiling in neuropathological diagnosis of central nervous system tumors in children, adolescent and young adults [0.03%]
甲基化谱分析在儿童、青少年和年轻人中枢神经系统肿瘤神经病理诊断中的作用
Anna Maria Buccoliero,Laura Giunti,Mirko Scagnet et al.
Anna Maria Buccoliero et al.
Methylation of CpG islands plays a crucial role in the regulation of gene expression. The study of DNA methylation profiles offers deep insights into key oncogenic processes and facilitates the differentiation of tumor entities at the epige...
AI-assisted sentinel lymph node examination and metastatic detection in breast cancer: the potential of ChatGPT for digital pathology research [0.03%]
人工智能辅助乳腺癌哨点淋巴结检查和转移检测：ChatGPT在数字病理学研究中的潜力
Giuseppe Angelico,Saveria Spadola,Angela Santoro et al.
Giuseppe Angelico et al.
Objective: Traditional pathological examination of lymph nodes is labor-intensive and has shown variability in diagnostic accuracy. Recent advancements in artificial intelligence (AI) provide promising opportunities to en...
Clinicopathological and molecular perspectives on thoracic SMARCA4-deficient undifferentiated tumors and SMARCA4-deficient non-small cell lung carcinomas [0.03%]
胸部SMARCA4缺陷型未分化肿瘤和SMARCA4缺陷型非小细胞肺癌的临床病理及分子特点分析
Sumanta Das,Pallavi Mishra,Sunita Ahlawat
Sumanta Das
SMARCA4-deficient tumors of the thoracic cavity represent a newly emerging group of aggressive neoplasms driven by inactivation of the SMARCA4 gene, a key member of the SWI/SNF chromatin remodeling complex. These tumors are broadly classifi...
Massimo Barberis
Massimo Barberis