The routine use of a digital tool for the tumor cell fraction quantification in molecular pathology: an international validation of QuANTUM [0.03%]
一种在分子病理中量化肿瘤细胞分数的数字工具的国际验证
Vincenzo L&#x;Imperio,Giulia Capitoli,Giorgio Cazzaniga et al.
Vincenzo L&#x;Imperio et al.
Objective: The absolute and relative quantification of tumor cell fraction (TCF) in tissue samples for molecular pathology testing is time-consuming and poorly reproducible. ...
Homologous recombination deficiency testing in ovarian cancer: the diagnostic experience of a referral Italian institution [0.03%]
同源重组缺陷在卵巢癌中的诊断经验——意大利一家转诊机构的报告
Francesco Pepe,Gianluca Russo,Amedeo Cefaliello et al.
Francesco Pepe et al.
Aims: Recently, precision medicine has drastically modified clinical paradigm for the clinical stratification of high-grade serous ovarian cancer (HGSOC) patients. International societies approved poly (ADP-ribose) polyme...
Invasiveness or growth pattern in urothelial tumours. A perspective to rethink the current WHO classification [0.03%]
侵袭性或尿路上皮肿瘤的生长模式。重新思考当前WHO分类的一个视角
Jiyeon Lee,Sangjoon Choi,Ghee Young Kwon
Jiyeon Lee
According to the current WHO classification, urothelial tumors consist of non-invasive urothelial neoplasms and invasive urothelial carcinoma which is supposed to include all tumors with invasion regardless of extent and pattern. Some patho...
Lights and shadows of microsatellite status characterization in gastrointestinal cancers in the era of cancer precision therapy [0.03%]
精准肿瘤治疗时代胃肠癌微卫星状态表征的进展与挑战
Jessica Gasparello,Vittoria Matilde Piva,Valentina Angerilli et al.
Jessica Gasparello et al.
The introduction of immunotherapy has dramatically changed the paradigm of solid tumor treatment with the creation of novel therapeutic opportunities even for tumors that currently lack valid therapeutic options in the advanced or metastati...
Stefano Marletta,Isabella Castellano,Francesca Caumo et al.
Stefano Marletta et al.
Currently, percutaneous sampling via core needle or vacuum-assisted biopsy is the primary choice to guide the management of patients with clinical or screen-detected breast lesions. Preoperative biopsies allow physicians to get pathological...
Practice Guideline
Pathologica. 2025 Jun;117(3):178-198. DOI:10.32074/1591-951X-1113 2025
Clinical needs and pathology's answers in neuroendocrine neoplasms of the lung [0.03%]
肺神经内分泌肿瘤的临床需求和病理学应对措施
Giuseppe Pelosi,Alice Laffi,Mauro Papotti et al.
Giuseppe Pelosi et al.
Lung neuroendocrine neoplasms (NENs) make up a variegated ensemble of malignancies encompassing typical carcinoid (TC) and atypical carcinoid (AC). These are low to intermediate grade neuroendocrine tumors (NETs), and large cell neuroendocr...
Immune checkpoint inhibitor therapy in metastatic renal cell carcinoma: tumour response and immune-related renal vasculitis following cytoreductive nephrectomy [0.03%]
肾细胞癌转移患者的免疫检查点抑制剂治疗：减瘤性肾切除术后的肿瘤应答及与免疫相关的肾脏血管炎
Ekta Jain,Jorge A Diaz,Mustafa Goksel et al.
Ekta Jain et al.
Objective: Therapeutic landscape of metastatic renal cell carcinoma (mRCC) has transformed over the last 2 decades, particularly with the advent of immune checkpoint inhibitors (ICI). While ICI offer therapeutic benefits,...
Michela Campora,Giampiero Negri,Virgilio Longari et al.
Michela Campora et al.
Published Erratum
Pathologica. 2025 Apr;117(2):173-177. DOI:10.32074/1591-951X-1054ER 2025
When to think of Sarcina sp. in histopathologic examination of gastrointestinal tract: insights from a one-year-old with esophagitis and gastric outlet obstruction [0.03%]
梭状芽胞杆菌在胃肠道组织病理检查中的考虑时机：一例食管炎和幽门狭窄患儿的启示
Farzaneh Afshari,Maryam Khalesi,Nema Mohammadian Roshan et al.
Farzaneh Afshari et al.
A 20th century case of noma infection following typhoid fever from the Morgagni Museum (Padua, Italy) [0.03%]
一例摩尔加尼博物馆（意大利帕多瓦）的大叶性溶组织内阿米巴病标本：20世纪发生的溃疡坏死性口炎-面部综合征及伤寒症病例
Irene Kollhof,Giovanni Magno
Irene Kollhof
Noma is a potentially fatal, gangrenous disease that leads to tissue destruction in the face. It has been proven to develop mostly in children living in extreme poverty. There is a lack of data regarding microbiological...
Case Reports
Pathologica. 2025 Apr;117(2):165-170. DOI:10.32074/1591-951X-1092 2025