Alessandra Celi,Rossella Bruno,Paola Vignali et al.
Alessandra Celi et al.
We describe the case of a NUT carcinoma of the thorax in a 27-year-old male, non-smoker, presenting a voluminous neoformation in the hilum and the left side of the mediastinum infiltrating heart and great vessels. The biopsy revealed a poor...
Case Reports
Pathologica. 2025 Sep;117(4):403-408. DOI:10.32074/1591-951X-N896 2025
Lung and nodal hairy cell leukemia with concurrent infectious granulomatosis: a mimic of metastatic lung epithelial neoplasia [0.03%]
伴发感染性肉芽肿的肺和淋巴结毛细胞白血病——一种肺上皮肿瘤转移的假象
Massimiliano Mancini,Giulio Maurizi,Evelina Rogges et al.
Massimiliano Mancini et al.
Hairy cell leukemia (HCL) is a rare, indolent B-cell neoplasm, typically involving bone marrow, spleen, and peripheral blood, with extranodal sites rarely affected. Herein, we present the unique case of a 52-year-old man with lung and lymph...
Case Reports
Pathologica. 2025 Sep;117(4):397-402. DOI:10.32074/1591-951X-N831 2025
Mesonephric-like metaplasia of the endometrium in a woman treated with letrozole: morphological, immunohistochemical and molecular analysis [0.03%]
来曲唑治疗妇女的子宫内膜中肾样化生：形态学、免疫组化和分子分析
Antonio Travaglino,Angela Santoro,Damiano Arciuolo et al.
Antonio Travaglino et al.
Endometrial mesonephric-like adenocarcinoma (MLA) is thought to arise from endometrial epithelium through a Müllerian-to-mesonephric transdifferentiation. However, no benign or precancerous mesonephric-like endometrial lesions have been re...
Case Reports
Pathologica. 2025 Sep;117(4):393-396. DOI:10.32074/1591-951X-N774 2025
TFE3-rearranged and TFEB-altered renal cell carcinoma: from classification to real-life. Insights from a national Italian survey [0.03%]
TFE3重排和TFEB改变的肾细胞癌：从分类到现实。来自意大利全国调查的见解
Stefano Marletta,Anna Caliò,Giuseppe Nicolò Fanelli et al.
Stefano Marletta et al.
Objective: Ongoing discoveries in cancer research keep expanding the landscape of renal cell carcinoma classification, particularly for "molecularly-defined" tumors like TFE3-rearranged and TFEB-altered renal cell carcino...
Oncotype DX in clinical practice: impact on treatment decisions and healthcare system economy [0.03%]
OncotypeDX在临床实践中的影响：对治疗决策和卫生系统经济的影响
Alessia Capozzi,Silvia Maria Rossi,Giovanna Sabarese et al.
Alessia Capozzi et al.
Objective: The aim of this study is to assess the impact of Oncotype DX on treatment decisions and healthcare economy. Methods: Data we...
Current approaches, barriers, and future directions in pleural mesothelioma diagnostics: results from an Italian National Survey [0.03%]
意大利全国性调查的目前方法、障碍及未来方向在胸膜间皮瘤诊断中的应用：结果报告
Federica Pezzuto,Gianluca Lopez,Francesca Barbisan et al.
Federica Pezzuto et al.
Objective: This nationwide survey aimed to assess current diagnostic practices, adherence to international guidelines, and challenges encountered by Italian pathologists in the diagnosis of diffuse pleural mesothelioma (P...
Data-driven insights into post-autopsy consultations: causes of perinatal mortality and parental outcomes [0.03%]
数据驱动的尸检后咨询见解：围产期死亡原因及父母预后
Rosario Barranco,Matteo Lorenzoni,Francesco Ausania et al.
Rosario Barranco et al.
Objective: Perinatal mortality deeply affects parents and healthcare providers. Post-autopsy consultations (PACs) help parents understand the causes of fetal death and offer emotional support. This study evaluates their e...
HER2-positive neuroendocrine breast carcinoma: a case study uncovers CCND1, FGF19, and IGF1R amplifications as new molecular drivers [0.03%]
HER2阳性神经内分泌乳腺癌：一项案例研究发现CCND1、FGF19和IGF1R扩增为新的分子驱动因素
Margherita Zordan,Elena Fiorio,Valeria Maffeis et al.
Margherita Zordan et al.
Primary neuroendocrine carcinoma of the breast (NEBC) is a rare entity among breast malignancies, and is usually associated with a more aggressive clinical course compared to other types of invasive breast cancer. Although some studies have...
Case Reports
Pathologica. 2025 Sep;117(4):348-356. DOI:10.32074/1591-951X-N981 2025
SPOP and MMR/MSI alterations in prostate cancer: relationship with PD-L1, TILs and AR expression [0.03%]
前列腺癌中SPOP和MMR/MSI改变与PD-L1、肿瘤浸润淋巴细胞和AR表达之间的关系研究
Vincenzo Fiorentino,Emanuela Germanà,Gabriele Ricciardi et al.
Vincenzo Fiorentino et al.
Objective: Despite the promising introduction of anti-PD-L1 therapy for advanced stage of prostate cancer (PCa), recent studies have demonstrated limited success, suggesting the need to improve patient selection. ...
Clinical autopsy: methodological applications and scientific perspectives in post-mortem diagnostics [0.03%]
尸体剖验的方法学应用及尸检诊断的科学视角
Martina Padovano,Matteo Scopetti,Federico Manetti et al.
Martina Padovano et al.
Objective: To analyze mortality from natural causes in hospital and out-of-hospital settings using clinical autopsy, emphasizing its methodological rigor and scientific contributions. ...