MesoRet: a reticulin stain-based deep learning algorithm to assist diffuse mesothelioma subtyping [0.03%]
基于网状纤维染色的深度学习算法辅助弥漫性间皮瘤分型研究-MesoRet
Giulia Orlando,Anna Paola Ferrero,Giorgia Andrea Impalà et al.
Giulia Orlando et al.
Objective: To develop and validate a deep learning model trained on reticulin-stained whole slide images (MesoRet) to accurately identify transitional features and assist in the histologic subtyping of diffuse mesotheliom...
Interventional pathologist and intraoperative surgical margin evaluation of radical prostatectomy specimens ex-vivo confocal microscopy vs. frozen section evaluation [0.03%]
术中根治性前列腺切除标本切缘评估共聚焦显微镜与冰冻切片的对比研究
Alessia Cimadamore,Liang Cheng,Antonio Lopez-Beltran et al.
Alessia Cimadamore et al.
Marked hepatic fibrosis with progression towards cirrhosis in generalized arterial calcification of infancy: an unreported association observed in a case carryng a novel ENPP1 variant [0.03%]
婴儿期全身动脉钙化的肝脏纤维化进展至肝硬化的病例报道及携带新型ENPP1变异案例分析
Anna Maria Buccoliero,Giorgia Mancano,Maria Luce Cioni et al.
Anna Maria Buccoliero et al.
Generalized arterial calcification of infancy (GACI) is a rare autosomal recessive disorder characterized by dysregulated calcium-phosphate metabolism, leading to mineral deposition within the internal elastic lamina of medium- and large-si...
Case Reports
Pathologica. 2025 Dec;117(6):610-617. DOI:10.32074/1591-951X-1624 2025
Gastric perineurioma detected in routine endoscopy biopsy practice: case report and review of clinico-pathological findings in the literature [0.03%]
内镜活检中发现胃神经束膜瘤一例及文献中临床病理特征回顾
Ilaria Girolami,Stefania Neri,Federico Desideri et al.
Ilaria Girolami et al.
Perineuriomas are soft tissue neoplasms composed almost entirely of cells resembling perineurium and their occurrence in gastrointestinal tract is quite rare, with most of reported cases occurring in the colon. No more than 12 cases of gast...
Relevance of next-generation sequencing in the differential diagnosis of meningeal mesenchymal tumors: primary meningeal dedifferentiated chondrosarcoma of the cavernous sinus [0.03%]
下一代测序在脑膜间叶肿瘤鉴别诊断中的意义—海绵窦原发脑膜软骨肉瘤去分化型一例报告
Nicolò Caldonazzi,Gonzalo Hernandez Gamero,Andrea Mafficini et al.
Nicolò Caldonazzi et al.
Primary mesenchymal tumors of the meninges include various types, with meningioma being the most prevalent. Non-meningothelial primary tumors of the meninges are uncommon and present diagnostic difficulties due to their potential morphologi...
Case Reports
Pathologica. 2025 Dec;117(6):598-602. DOI:10.32074/1591-951X-1368 2025
Immunohistochemical and molecular profiling of uveal melanoma: clinicopathological correlations from an Italian cohort [0.03%]
意大利队列的眼脉络膜黑色素瘤免疫组化和分子分型结果及其临床病理相关性研究
Francesco Fortarezza,Giovanni Zarrilli,Giada Munari et al.
Francesco Fortarezza et al.
Objective: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by distinct histopathological and molecular features and often associated with poor prognosis due to its high metas...
Distinction of thymic carcinoma and type B3 thymoma using ancillary biomarkers [0.03%]
利用辅助性生物标志物区分胸腺癌和B3型胸腺瘤
Anello Marcello Poma,Alessandra Celi,Vittorio Aprile et al.
Anello Marcello Poma et al.
Objective: Thymic carcinomas (TC) are rare and understudied tumors. Pitfalls exist with TC diagnosis, and biomarkers are needed to support the pathologist. Here, we tested a series of biomarkers to differentiate TC from t...
PIK3CA testing in HR+/HER2- metastatic breast cancer: assessing pathology laboratories capacity and needs [0.03%]
激素受体阳性/HER2阴性转移性乳腺癌中的PIK3CA检测：评估病理实验室的能力和需求
Eltjona Mane,Giulia Cursano,Konstantinos Venetis et al.
Eltjona Mane et al.
The management of hormone receptor-positive/HER2-negative (HR+/HER2-) metastatic breast cancer (MBC) relies on molecular testing to inform treatment decisions. PIK3CA mutations, present in ~40% of cases, represent a key predictive biomarker...
Standardizing the pathologic assessment of HER2-(ultra)low breast cancer: insights from a national Italian project [0.03%]
HER2低阳性乳腺癌病理评估标准化：意大利全国项目见解
Bruna Cerbelli,Stefano Marletta,Michelina Amato et al.
Bruna Cerbelli et al.
Objective: Novel therapies for HER2-(ultra)low breast cancer (BC) have changed the traditional binary classification of HER2 status into a multi-tiered system that captures the full spectrum of expression as determined by...
Next-generation sequencing methodologies to identify patients for targeted therapy: focus on HR+/HER2- metastatic breast cancer [0.03%]
下一代测序技术在靶向治疗患者选择中的应用——HR+/HER2-转移性乳腺癌的聚焦研究
Umberto Malapelle,Simonetta Buglioni,Isabella Castellano et al.
Umberto Malapelle et al.
Alterations in the phosphoinositide 3-kinase (PI3K)/AKT/PTEN signaling pathway are a well-recognized mechanism of resistance in hormone receptor-positive, HER2-negative metastatic breast cancer (HR+/HER2- mBC). These alterations are present...